Synphilin 1 Polyclonal Antibody, Invitrogen™

Description

• Reconstitute in 100 μL of sterile water
• Centrifuge to remove any insoluble material
• After reconstitution keep aliquots at -20 °C for a higher stability, and at 4 °C with an appropriate antibacterial agent
• Glycerol (1:1) may be added for an additional stability
• Avoid repetitive freeze/thaw cycles
• Parkinson is the second most common neurodegenerative disease after Alzheimer's
• About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease
• The mutation is the most common cause of Parkinson disease identified to date
• Synuclein alpha interacting protein (Synphilin-1) contains several protein-protein interaction domains and interacts with alpha synuclein in neurons
• Mutations of SNCAIP have been linked to Parkinson disease
• The amino acid sequence of synphilin-1 shows extensive homology with its human counterpart, especially in regions containing ankyrin-like motifs and the coiled-coil domain
• Expression of mouse synphilin-1 in tissues is similar to its human counterpart
• Synphilin-1 has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and that Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1
• Role of synphilin-1 in synaptic function and protein degradation and in the molecular mechanisms leading to neurodegeneration in Parkinson disease.