TrkB Polyclonal Antibody, Invitrogen™

Description

• Reconstitute in 100 μL of sterile water
• Centrifuge to remove any insoluble material
• After reconstitution keep aliquots at -20 °C for a higher stability, and at 4 °C with an appropriate antibacterial agent
• Glycerol (1:1) may be added for an additional stability
• Avoid repetitive freeze/thaw cycles
• NTRK2 (TRKB) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system
• NTRK2 is the receptor for brain-derived neurotrophic factor (BDNF)
• Together, NTRK2 and BDNF regulate both short-term synaptic functions and long-term potentiation of brain synapses
• TrkB is involved in the development and maintenance of the nervous system
• Moreover, Trk B is a tyrosine kinase gene highly related to Trk A
• Trk B expression is confined to tissues within the central and peripheral nervous systems
• The brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, can induce rapid phosphorylation on tyrosine of Trk B gp145, one of the receptors encoded by Trk B, although BDNF elicits a response at least two orders of magnitude greater than NT-3
• TrkB is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway
• Signaling through TrkB leads to cell differentiation
• Mutations in the TrkB gene have been associated with obesity and mood disorders
• Alternate transcriptional splice variants encoding different isoforms have been found for the TrkB gene.