Factor XII Heavy chain Monoclonal Antibody (B7C9), Invitrogen™

Description

• MA1-10828 detects Factor XII heavy chain, from human samples
• MA1-10828 has been successfully used in ELISA and Western blot applications
• By Western blot, this antibody detects a ∽50 kDa band representing the non-reduced heavy chain of Factor XII from normal human plasma
• The MA1-10828 immunogen is purified human Factor XII
• Hemostasis following tissue injury involves the deployment of essential plasma procoagulants which are involved in a blood coagulation cascade leading to the formation of insoluble fibrin clots and the promotion of platelet aggregation
• Factor XII, (FXII) a blood coagulation factor, is a serum glycoprotein that participates in fibrinolysis, as well as the generation of bradykinin and angiotensin
• An enzyme of the serine protease (or serine endopeptidase) class, it activates both Factor XI and prekallikrein in the coagulation cascade
• Factor XII deficiency, a rare hereditary disorder slightly more prevalent among Asians, does not cause excessive hemorrhaging since other coagulation factors compensate for it
• Researchers have still reported Factor XII deficiency to be a risk factor for the development of arterial and venous thromboembolism
• The gene for human Factor XII maps to the very end of the long arm of the fifth chromosome (5q33-qter).