Gram Negative Endotoxin Monoclonal Antibody (HEC11-445.2), Invitrogen™

Description

• MA1-10691 detects Endotoxin from E
• aerogenes, S
• marcescens, P
• mirabilis, A
• calcoaceticus, and Ps
• aeruginosa samples
• MA1-10691 has been successfully used in ELISA applications
• The MA1-10691 immunogen is E
• coli serotypes: O:111, B4 J5
• Endotoxins are part of the outer membrane of the cell wall of gram-negative bacteria
• Endotoxins are invariably associated with gram-negative bacteria whether the organisms are pathogens or not
• Although the term &quoteendotoxin&quote is occasionally used to refer to any cell-associated bacterial toxin, it is properly reserved to refer to the lipopolysaccharide complex associated with the outer membrane of gram-negative bacteria such as E
• coli, Salmonella, Shigella, Pseudomonas, Neisseria, Haemophilus, and other leading pathogens
• The biological activity of endotoxin is associated with the lipopolysaccharide (LPS)
• Toxicity is associated with the lipid component (Lipid A) and immunogenicity is associated with the polysaccharide components
• The cell wall antigens (O antigens) of gram-negative bacteria are components of LPS
• LPS elicits a variety of inflammatory responses in an animal
• Because it activates complement by the alternative (properdin) pathway, it is often part of the pathology of gram-negative bacterial infections.