01-676-565
PAI1 Monoclonal Antibody (MA-55F4C12), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 01-676-565-Each-of-1 | In Stock | ₹ 57,154.08 |
01-676-565 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 57,154.08
GST (18%): ₹ 10,287.734
Total Price: ₹ 67,441.814
Antigen
PAI1
Classification
Monoclonal
Concentration
0.1 mg/mL
Formulation
PBS with 0.1% BSA and no preservative
Gene Accession No.
P05121, P20961, P22777
Gene Symbols
Serpine1
Immunogen
Human PAI-1.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG1
Applications
ELISA, Functional Assay
Clone
MA-55F4C12
Conjugate
Unconjugated
Gene
Serpine1
Gene Alias
Endothelial plasminogen activator inhibitor; nexin, plasminogen activator inhibitor type 1; PAI; PAI1; PAI-1; PAI1 protein; PAI1A; Pai1aa; Planh; Planh1; plas; plasminogen activator inhibitor; plasminogen activator inhibitor 1; plasminogen activator inhibitor I; plasminogen activator inhibitor, type I; plasminogen activator inhibitor-1; Plasminogen activator inhibitor-1 precursor (PAI-1) (Endothelial plasminogen activator inhibitor) (PAI); putative plasminogen activator inhibitor-1; RATPAI1A; serine (or cysteine) peptidase inhibitor, clade E, member 1; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; serine (or cysteine) proteinase inhibitor, clade E, member 1; serine (or cysteine) proteinase inhibitor, member 1; serpin E1; serpin family E member 1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; SERPINE1; SERPINE-1
Host Species
Mouse
Purification Method
purified
Regulatory Status
RUO
Gene ID (Entrez)
18787, 24617, 5054
Content And Storage
4° C
Form
Liquid
Description
- MA1-40225 detects PAI-1 from human, mouse, and rat samples
- MA1-40225 has been successfully used in functional assays and ELISA applications
- The MA1-40225 immunogen is human PAI-1
- Endotoxin <24 EU/mg
- The epitope of MA1-40225 is within the stretch of 29 amino acids in PAI-1 (region Glu128 -Ala131)
- Glu128, Val129, Glu130, Arg131 and Lys154 are the major determinants
- All five residues act cooperatively in the binding to MA-55F4C12 and constitute the epitope
- The epitope of the antibody does not cover the complete alpha-helix F and turn connecting alpha-helix F and beta-strand s3A, but is restricted to the hinge region between alpha-helix F and the main part of the PAI-1 molecule
- MA1-40225 is a ‘switching’ antibody, capable of inducing a non-inhibitory substrate form of PAI-1
- The antibody cross reacts with rat and mouse PAI-1
- PAI1 (plasminogen activator inhibitor 1) belongs to serine protease inhibitor superfamily, and is the principal inhibitor of tissue-type and urokinase-type plasminogen activators (tPA and uPA)
- Platelets are the main source of the circulating PAI11, but it is synthesized and secreted by many tissue and cell types, including fibroblasts, smooth muscle cells, endothelial cells, hepatocytes, and inflammatory cells
- Expression of PAI11 can be regulated at the transcriptional level by many factors including growth factors, cytokines, hormones, inflammatory factors, glucose or lipid metabolites, vascular tone regulating factors, chemicals, and other environmental or physical factors
- PAI1 is present at increased levels in various disease states, and has been linked to an increased occurrence of thrombosis in obesity, thrombophilia and the metabolic syndrome
- Defects in PAI-1 are characterized by abnormal bleeding
- PAI1 mediates inhibition of fibrinolysis by inhibiting the activity of plasminogen activator, and may promote neuronal survival
- Other defects in PAI1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency)
- Alternatively spliced transcript variants encoding different isoforms of PAI1 have been found.
Compare Similar Items
Show Difference
Antigen: PAI1
Classification: Monoclonal
Concentration: 0.1 mg/mL
Formulation: PBS with 0.1% BSA and no preservative
Gene Accession No.: P05121, P20961, P22777
Gene Symbols: Serpine1
Immunogen: Human PAI-1.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG1
Applications: ELISA, Functional Assay
Clone: MA-55F4C12
Conjugate: Unconjugated
Gene: Serpine1
Gene Alias: Endothelial plasminogen activator inhibitor; nexin, plasminogen activator inhibitor type 1; PAI; PAI1; PAI-1; PAI1 protein; PAI1A; Pai1aa; Planh; Planh1; plas; plasminogen activator inhibitor; plasminogen activator inhibitor 1; plasminogen activator inhibitor I; plasminogen activator inhibitor, type I; plasminogen activator inhibitor-1; Plasminogen activator inhibitor-1 precursor (PAI-1) (Endothelial plasminogen activator inhibitor) (PAI); putative plasminogen activator inhibitor-1; RATPAI1A; serine (or cysteine) peptidase inhibitor, clade E, member 1; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; serine (or cysteine) proteinase inhibitor, clade E, member 1; serine (or cysteine) proteinase inhibitor, member 1; serpin E1; serpin family E member 1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; SERPINE1; SERPINE-1
Host Species: Mouse
Purification Method: purified
Regulatory Status: RUO
Gene ID (Entrez): 18787, 24617, 5054
Content And Storage: 4° C
Form: Liquid
Antigen:
PAI1
Classification:
Monoclonal
Concentration:
0.1 mg/mL
Formulation:
PBS with 0.1% BSA and no preservative
Gene Accession No.:
P05121, P20961, P22777
Gene Symbols:
Serpine1
Immunogen:
Human PAI-1.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG1
Applications:
ELISA, Functional Assay
Clone:
MA-55F4C12
Conjugate:
Unconjugated
Gene:
Serpine1
Gene Alias:
Endothelial plasminogen activator inhibitor; nexin, plasminogen activator inhibitor type 1; PAI; PAI1; PAI-1; PAI1 protein; PAI1A; Pai1aa; Planh; Planh1; plas; plasminogen activator inhibitor; plasminogen activator inhibitor 1; plasminogen activator inhibitor I; plasminogen activator inhibitor, type I; plasminogen activator inhibitor-1; Plasminogen activator inhibitor-1 precursor (PAI-1) (Endothelial plasminogen activator inhibitor) (PAI); putative plasminogen activator inhibitor-1; RATPAI1A; serine (or cysteine) peptidase inhibitor, clade E, member 1; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; serine (or cysteine) proteinase inhibitor, clade E, member 1; serine (or cysteine) proteinase inhibitor, member 1; serpin E1; serpin family E member 1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; SERPINE1; SERPINE-1
Host Species:
Mouse
Purification Method:
purified
Regulatory Status:
RUO
Gene ID (Entrez):
18787, 24617, 5054
Content And Storage:
4° C
Form:
Liquid
Antigen: IBA1
Classification: Monoclonal
Concentration: 0.1 mg/mL
Formulation: PBS with 0.1% BSA and 0.02% sodium azide
Gene Accession No.: P55008, P55009
Gene Symbols: AIF1
Immunogen: Recombinant human AIF-1
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Rat
Product Type: Antibody
Isotype: IgG2b
Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
Clone: 1022-5
Conjugate: Unconjugated
Gene: AIF1
Gene Alias: AI607846; AIF1; AIF-1; Allograft inflammatory factor 1; balloon angioplasty responsive transcript; balloon angioplasty-responsive transcript 1; Bart1; BART-1; D17H6S50E; DADB-70P7.8; DASS-82G15.2; Em:AF129756.17; G1; Iba; Iba1; interferon gamma responsive transcript; ionized calcium binding adapter molecule 1; ionized calcium-binding adapter molecule 1; IRT1; IRT-1; microglia response factor; Mrf1; MRF-1; protein BART-1; protein G1; testis specific
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 199, 29427
Content And Storage: 4° C
Form: Liquid
Antigen:
IBA1
Classification:
Monoclonal
Concentration:
0.1 mg/mL
Formulation:
PBS with 0.1% BSA and 0.02% sodium azide
Gene Accession No.:
P55008, P55009
Gene Symbols:
AIF1
Immunogen:
Recombinant human AIF-1
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Rat
Product Type:
Antibody
Isotype:
IgG2b
Applications:
ELISA, Immunohistochemistry (Paraffin), Western Blot
Clone:
1022-5
Conjugate:
Unconjugated
Gene:
AIF1
Gene Alias:
AI607846; AIF1; AIF-1; Allograft inflammatory factor 1; balloon angioplasty responsive transcript; balloon angioplasty-responsive transcript 1; Bart1; BART-1; D17H6S50E; DADB-70P7.8; DASS-82G15.2; Em:AF129756.17; G1; Iba; Iba1; interferon gamma responsive transcript; ionized calcium binding adapter molecule 1; ionized calcium-binding adapter molecule 1; IRT1; IRT-1; microglia response factor; Mrf1; MRF-1; protein BART-1; protein G1; testis specific
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
199, 29427
Content And Storage:
4° C
Form:
Liquid
Antigen: EMAP II
Classification: Monoclonal
Concentration: 0.1 mg/mL
Formulation: PBS with 0.1% BSA and 0.02% sodium azide
Gene Accession No.: Q12904
Gene Symbols: Aimp1
Immunogen: Recombinant human EMAP-II
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Rat
Product Type: Antibody
Isotype: IgG2b
Applications: ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Clone: 546-2
Conjugate: Unconjugated
Gene: Aimp1
Gene Alias: 9830137A06Rik; aaRS-interacting multifunctional protein 1; AIMP1; AIMP1/p43; AIMP1-PA; Aminoacyl tRNA synthase complex-interacting multifunctional protein 1; aminoacyl tRNA synthetase complex interacting multifunctional protein 1; aminoacyl tRNA synthetase complex-interacting multifunctional protein 1; aminoacyl-tRNA synthetase-interacting multifunctional protein 1; ARS inducible multifunctional protein 1; ARS-interacting multifunctional protein 1; CG8235; CG8235-PA; Dmel\CG8235; Dmel_CG8235; EMAP2; EMAP-2; EMAPII; EMAP-II; endothelial monocyte activating polypeptide 2; endothelial monocyte-activating polypeptide 2; Endothelial monocyte-activating polypeptide II; endothelial-monocyte activating polypeptide II; HLD3; mca1; multisynthase complex auxiliary component p43; multisynthetase complex auxiliary component p43; p43; SCYE1; Small inducible cytokine subfamily E member 1; small inducible cytokine subfamily E, member 1; small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating)
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 114632, 9255
Content And Storage: 4° C
Form: Liquid
Antigen:
EMAP II
Classification:
Monoclonal
Concentration:
0.1 mg/mL
Formulation:
PBS with 0.1% BSA and 0.02% sodium azide
Gene Accession No.:
Q12904
Gene Symbols:
Aimp1
Immunogen:
Recombinant human EMAP-II
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Rat
Product Type:
Antibody
Isotype:
IgG2b
Applications:
ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Clone:
546-2
Conjugate:
Unconjugated
Gene:
Aimp1
Gene Alias:
9830137A06Rik; aaRS-interacting multifunctional protein 1; AIMP1; AIMP1/p43; AIMP1-PA; Aminoacyl tRNA synthase complex-interacting multifunctional protein 1; aminoacyl tRNA synthetase complex interacting multifunctional protein 1; aminoacyl tRNA synthetase complex-interacting multifunctional protein 1; aminoacyl-tRNA synthetase-interacting multifunctional protein 1; ARS inducible multifunctional protein 1; ARS-interacting multifunctional protein 1; CG8235; CG8235-PA; Dmel\CG8235; Dmel_CG8235; EMAP2; EMAP-2; EMAPII; EMAP-II; endothelial monocyte activating polypeptide 2; endothelial monocyte-activating polypeptide 2; Endothelial monocyte-activating polypeptide II; endothelial-monocyte activating polypeptide II; HLD3; mca1; multisynthase complex auxiliary component p43; multisynthetase complex auxiliary component p43; p43; SCYE1; Small inducible cytokine subfamily E member 1; small inducible cytokine subfamily E, member 1; small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating)
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
114632, 9255
Content And Storage:
4° C
Form:
Liquid
Antigen: Galectin 3
Classification: Monoclonal
Concentration: 0.1 mg/mL
Formulation: PBS with 0.1% BSA and no preservative
Gene Accession No.: P16110, P17931
Gene Symbols: LGALS3
Immunogen: First 45 residues of human Galectin-3.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG1
Applications: ELISA, Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
Clone: B2C10
Conjugate: Unconjugated
Gene: LGALS3
Gene Alias: 35 kDa lectin; advanced glycation end-product receptor 3; AGE-R3; beta-galactosides-binding lectin; carbohydrate-binding protein 35; CBP 35; CBP30; CBP-30; CBP35; epsilon BP; gal3; gal-3; galactose-specific lectin 3; Galactoside-binding protein; GALBP; galectin 3; Galectin3; galectin-3; GALIG; GBP; IgE binding protein; igE-binding protein; L-29; L31; L-31; L-34; L-34 galactoside-binding lectin; Laminin-binding protein; lectin galactoside-binding soluble 3; lectin galactoside-binding soluble 3 protein; lectin L-29; lectin, galactose binding, soluble 3; lectin, galactoside binding soluble 3; lectin, galactoside-binding, soluble, 3; lectin, galactoside-binding, soluble, 3 (galectin 3); LGALS2; Lgals3; MAC2; Mac-2; Mac-2 antigen
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 16854, 3958
Content And Storage: 4° C
Form: Liquid
Antigen:
Galectin 3
Classification:
Monoclonal
Concentration:
0.1 mg/mL
Formulation:
PBS with 0.1% BSA and no preservative
Gene Accession No.:
P16110, P17931
Gene Symbols:
LGALS3
Immunogen:
First 45 residues of human Galectin-3.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG1
Applications:
ELISA, Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
Clone:
B2C10
Conjugate:
Unconjugated
Gene:
LGALS3
Gene Alias:
35 kDa lectin; advanced glycation end-product receptor 3; AGE-R3; beta-galactosides-binding lectin; carbohydrate-binding protein 35; CBP 35; CBP30; CBP-30; CBP35; epsilon BP; gal3; gal-3; galactose-specific lectin 3; Galactoside-binding protein; GALBP; galectin 3; Galectin3; galectin-3; GALIG; GBP; IgE binding protein; igE-binding protein; L-29; L31; L-31; L-34; L-34 galactoside-binding lectin; Laminin-binding protein; lectin galactoside-binding soluble 3; lectin galactoside-binding soluble 3 protein; lectin L-29; lectin, galactose binding, soluble 3; lectin, galactoside binding soluble 3; lectin, galactoside-binding, soluble, 3; lectin, galactoside-binding, soluble, 3 (galectin 3); LGALS2; Lgals3; MAC2; Mac-2; Mac-2 antigen
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
16854, 3958
Content And Storage:
4° C
Form:
Liquid