CD1a Monoclonal Antibody (CBT6), Invitrogen™

Description

• CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta 2 microglobulin
• CD1a is expressed by cortical thymocytes, Langerhan's cells and by interdigitating cells
• CD1a is also expressed by some malignancies of T cell lineage and in histiocytosis X
• CD1a is expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues
• CD1a is structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin
• The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells
• The human genome contains five CD1 family genes organized in a cluster on chromosome 1
• The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands
• CD1a localizes to the plasma membrane and recycles vesicles of the early endocytic system
• At least five CD1 genes (CD1a, b, c, d, and e) are identified
• Alternatively spliced transcript variants of CD1a have been observed, but their biological validity have not been determined.