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041475I

MilliporeSigma™ CD27, Rat, Unlabeled, Clone: RM27-3E5,

Manufacturer: MilliporeSigma™

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Pack Size	SKU	Availability	Price
Each of 1	041475I-Each-of-1	In Stock	₹ 42,968.31

041475I - Each of 1

₹ 42,968.31

In Stock

Quantity

Base Price: ₹ 42,968.31

GST (18%): ₹ 7,734.296

Total Price: ₹ 50,702.606

Antigen

CD27

Classification

Monoclonal

Concentration

Please refer to lot specific datasheet.

Formulation

Purified rat IgG2a in PBS without preservatives.

Gene Accession No.

P41272

Immunogen

Human IgG1 Fc-tagged recombinant mouse CD27 extracellular domain (Sumi, T., et al. (2008). Immunol. Lett. 119(1-2):91-96).

Quantity

100 μL

Research Discipline

Inflammation & Immunology

Gene ID (Entrez)

NP_001028298

Target Species

Mouse

Form

Purified

Applications

Neutralization

Clone

RM27-3E5

Conjugate

Unconjugated

Gene

Cd27, Tnfrsf7

Host Species

Rat

Purification Method

Protein G Purified

Regulatory Status

RUO

Primary or Secondary

Primary

Test Specificity

Clone RM27-3E5 enhanced anti-CD3-stimulated T-cell proliferation when immobilized in vitro and augmented OVA-specific CTL induction when administrated in vivo (Roberts, D.J., et al. (2010). J. Immunother. 33(8): 769 779; Sumi, T., et al. (2008). Immunol. Lett. 119(1-2):91-96).

Content And Storage

Stable for 1 year at 2°-8°C from date of receipt.

Isotype

IgG2a κ

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Description

CD27 antigen (UniProt P41272; also known as CD27, CD27L receptor, T-cell activation antigen CD27, Tumor necrosis factor receptor superfamily member 7) is encoded by the Cd27 (also known as Tnfrsf7) gene (Gene ID 21940) in murine species
CD27 is a TNF receptor superfamily member that binds to CD70 and mediates the survival, function, and differentiation of T-, B-, natural killer (NK), and plasma cells
Interaction with CD70 provides costimulation in T cells induces signaling events essential for cell proliferation, long-term maintenance of antigen-specific T cells, antiviral responses, antitumor immunity, and alloreactivity
CD27 ligation on B-cells by CD70 causes enhanced plasma cell formation and increased IgG production
CD27 is also used as a marker for memory B cells in the classification of B-cell deficiencies, including common variable immunodeficiency (CVID)
CD27 is synthesized with a signal peptide (a.a
1-23), which was removed posttranslationally to yield the mature type I transmembrane protein with an extracellular (a.a
24-182) composed of three TNFR-Cys repeats (a.a
26-63, 64-104, 105-141), followed by a transmembrane region (a.a
183-203), and a cytoplasmic tail (a.a
204-250).

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MilliporeSigma™

041475I

Antigen:

CD27

Classification:

Monoclonal

Concentration:

Please refer to lot specific datasheet.

Formulation:

Purified rat IgG2a in PBS without preservatives.

Gene Accession No.:

P41272

Immunogen:

Human IgG1 Fc-tagged recombinant mouse CD27 extracellular domain (Sumi, T., et al. (2008). Immunol. Lett. 119(1-2):91-96).

Quantity:

100 μL

Research Discipline:

Inflammation & Immunology

Gene ID (Entrez):

NP_001028298

Target Species:

Mouse

Form:

Purified

Applications:

Neutralization

Clone:

RM27-3E5

Conjugate:

Unconjugated

Gene:

Cd27, Tnfrsf7

Host Species:

Rat

Purification Method:

Protein G Purified

Regulatory Status:

RUO

Primary or Secondary:

Primary

Test Specificity:

Clone RM27-3E5 enhanced anti-CD3-stimulated T-cell proliferation when immobilized in vitro and augmented OVA-specific CTL induction when administrated in vivo (Roberts, D.J., et al. (2010). J. Immunother. 33(8): 769 779; Sumi, T., et al. (2008). Immunol. Lett. 119(1-2):91-96).

Content And Storage:

Stable for 1 year at 2°-8°C from date of receipt.

Isotype:

IgG2a κ

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Antigen:

Classification:

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Isotype:

MilliporeSigma™ CD27, Rat, Unlabeled, Clone: RM27-3E5,

Select a Size

Select a Size

Properties

Antigen

Classification

Concentration

Formulation

Gene Accession No.

Immunogen

Quantity

Research Discipline

Gene ID (Entrez)

Target Species

Form

Applications

Clone

Conjugate

Gene

Host Species

Purification Method

Regulatory Status

Primary or Secondary

Test Specificity

Content And Storage

Isotype

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