05-184-AF488
MilliporeSigma™ Mouse anti-Src, Clone: GD11, Alexa Fluor 488,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 05-184-AF488-Each-of-1 | In Stock | ₹ 52,621.97 |
05-184-AF488 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,621.97
GST (18%): ₹ 9,471.955
Total Price: ₹ 62,093.925
Antigen
Src
Classification
Monoclonal
Conjugate
Alexa Fluor 488
Gene Accession No.
P00526
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Avian, Human, Mink, Mouse, Rat
Form
Purified
Applications
Immunocytochemistry
Clone
GD11
Formulation
Purified mouse monoclonal IgG1 antibody conjugate in PBS with 15mg/mL BSA and 0.1% sodium azide.
Gene Symbols
V-SRC; SRC
Immunogen
Recombinant PrA-RSV p60src.
Quantity
100 μL
Research Discipline
Cell Structure
Gene ID (Entrez)
P00526.3
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
Isotype
IgG1
Description
- Specifically detects Src clone: GD11 in Avian, Human, Mink, Mouse, Rat samples, and it is validated for Immunocytochemistry Tyrosine-protein kinase transforming protein Src (EC 2.7.10.2; UniProt P00526; also known as p60-Src, pp60v-src, v-Src) is encoded by the V-SRC gene (Gene ID 1491925) of Rous sarcoma virus strain Prague C (RSV-PrC)
- Rous sarcoma virus (RSV) V-SRC gene is the first retroviral oncogene discovered
- V-SRC encodes the v-Src tyrosine kinase that transforms infected host cells into uncontrolled mitosis, providing abundant cells for fresh infection
- The non-oncogenic chicken c-Src (cellular Src) gene structurally related to v-Src was discovered later in 1979 by J
- Michael Bishop and Harold E
- Varmus
- It is believed that RSV originally took up the chicken proto-oncogene SRC (Gene ID 396442; UniProt P00523) and incorporated into its genome in the mutated concogene form
- c-Src contains six functional regions, Src homology 4 (SH4) domain, unique region, SH3 domain, SH2 domain, catalytic domain, and short regulatory tail
- In its inactive state, Src is phosphorylated at Tyr527
- The pTyr527 interacts with the SH2 domain which helps the SH3 domain interact with the linker domain and consequently keeps the inactive unit tightly bound
- Dephosphorylation of pTyr527 destabilizes the inactive conformation, opening up the SH3, SH2 and the kinase domains, leading to Tyr416 autophosphorylation and c-Src activation.
Compare Similar Items
Show Difference
Antigen: Src
Classification: Monoclonal
Conjugate: Alexa Fluor 488
Gene Accession No.: P00526
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Avian, Human, Mink, Mouse, Rat
Form: Purified
Applications: Immunocytochemistry
Clone: GD11
Formulation: Purified mouse monoclonal IgG1 antibody conjugate in PBS with 15mg/mL BSA and 0.1% sodium azide.
Gene Symbols: V-SRC; SRC
Immunogen: Recombinant PrA-RSV p60src.
Quantity: 100 μL
Research Discipline: Cell Structure
Gene ID (Entrez): P00526.3
Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
Isotype: IgG1
Antigen:
Src
Classification:
Monoclonal
Conjugate:
Alexa Fluor 488
Gene Accession No.:
P00526
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Avian, Human, Mink, Mouse, Rat
Form:
Purified
Applications:
Immunocytochemistry
Clone:
GD11
Formulation:
Purified mouse monoclonal IgG1 antibody conjugate in PBS with 15mg/mL BSA and 0.1% sodium azide.
Gene Symbols:
V-SRC; SRC
Immunogen:
Recombinant PrA-RSV p60src.
Quantity:
100 μL
Research Discipline:
Cell Structure
Gene ID (Entrez):
P00526.3
Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.
Isotype:
IgG1
Antigen: Src
Classification: Monoclonal
Conjugate: Unconjugated
Gene Accession No.: NM_005417.3; NM_198291.1
Host Species: Mouse
Purification Method: Protein G purfied
Regulatory Status: __
Primary or Secondary: Primary
Target Species: Avian, Human, Mink, Mouse, Rat
Form: Purified
Applications: Immunoprecipitation, Western Blot
Clone: GD11
Formulation: Protein G Purified immunoglobulin in Protein A Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105MNaCl, 0.035% sodium azide as a preservative.
Gene Symbols: SRC, c-src, p60-Src, SRC1, c-SRC, ASV, pp60c-src
Immunogen: Recombinant chicken pp60src; v-src
Quantity: 200 μg
Research Discipline: __
Gene ID (Entrez): __
Content And Storage: −20°C in undiluted aliquots for up to 24 months. Avoid repeated freeze/thaw cycles.
Isotype: IgG1
Antigen:
Src
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene Accession No.:
NM_005417.3; NM_198291.1
Host Species:
Mouse
Purification Method:
Protein G purfied
Regulatory Status:
__
Primary or Secondary:
Primary
Target Species:
Avian, Human, Mink, Mouse, Rat
Form:
Purified
Applications:
Immunoprecipitation, Western Blot
Clone:
GD11
Formulation:
Protein G Purified immunoglobulin in Protein A Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105MNaCl, 0.035% sodium azide as a preservative.
Gene Symbols:
SRC, c-src, p60-Src, SRC1, c-SRC, ASV, pp60c-src
Immunogen:
Recombinant chicken pp60src; v-src
Quantity:
200 μg
Research Discipline:
__
Gene ID (Entrez):
__
Content And Storage:
−20°C in undiluted aliquots for up to 24 months. Avoid repeated freeze/thaw cycles.
Isotype:
IgG1
Antigen: avian Src
Classification: Monoclonal
Conjugate: Unconjugated
Gene Accession No.: NM_005417.3; NM_198291.1
Host Species: Mouse
Purification Method: Protein G chromatography
Regulatory Status: __
Primary or Secondary: Primary
Target Species: Avian
Form: Purified
Applications: Immunocytochemistry, Immunoprecipitation, Western Blot
Clone: EC10
Formulation: 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, with 0.05% sodium azide
Gene Symbols: SRC, c-src, p60-Src, SRC1, c-SRC, ASV, pp60c-src
Immunogen: Recombinant chicken pp60src
Quantity: 200 μg
Research Discipline: __
Gene ID (Entrez): __
Content And Storage: −20°C for 24 months.
Isotype: IgG2b
Antigen:
avian Src
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene Accession No.:
NM_005417.3; NM_198291.1
Host Species:
Mouse
Purification Method:
Protein G chromatography
Regulatory Status:
__
Primary or Secondary:
Primary
Target Species:
Avian
Form:
Purified
Applications:
Immunocytochemistry, Immunoprecipitation, Western Blot
Clone:
EC10
Formulation:
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, with 0.05% sodium azide
Gene Symbols:
SRC, c-src, p60-Src, SRC1, c-SRC, ASV, pp60c-src
Immunogen:
Recombinant chicken pp60src
Quantity:
200 μg
Research Discipline:
__
Gene ID (Entrez):
__
Content And Storage:
−20°C for 24 months.
Isotype:
IgG2b
Antigen: __
Classification: __
Conjugate: __
Gene Accession No.: __
Host Species: __
Purification Method: __
Regulatory Status: __
Primary or Secondary: __
Target Species: __
Form: __
Applications: __
Clone: __
Formulation: __
Gene Symbols: __
Immunogen: __
Quantity: __
Research Discipline: __
Gene ID (Entrez): __
Content And Storage: __
Isotype: __
Antigen:
__
Classification:
__
Conjugate:
__
Gene Accession No.:
__
Host Species:
__
Purification Method:
__
Regulatory Status:
__
Primary or Secondary:
__
Target Species:
__
Form:
__
Applications:
__
Clone:
__
Formulation:
__
Gene Symbols:
__
Immunogen:
__
Quantity:
__
Research Discipline:
__
Gene ID (Entrez):
__
Content And Storage:
__
Isotype:
__