05-637-AF488

MilliporeSigma™ Mouse anti-Bmi-1, Clone: F6, Alexa Fluor 488,

Manufacturer: MilliporeSigma™

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Pack Size SKU Availability Price
Each of 1 05-637-AF488-Each-of-1 In Stock ₹ 61,151.90

05-637-AF488 - Each of 1

₹ 61,151.90

In Stock

Quantity

1

Base Price: ₹ 61,151.90

GST (18%): ₹ 11,007.342

Total Price: ₹ 72,159.242

Antigen

Bmi-1

Classification

Monoclonal

Conjugate

Alexa Fluor 488

Gene Accession No.

P25916

Host Species

Mouse

Purification Method

Protein G Purified

Regulatory Status

RUO

Primary or Secondary

Primary

Target Species

Human, Monkey

Form

Purified

Applications

Immunocytochemistry

Clone

F6

Formulation

Purified mouse conjugate antibody in PBS with 15mg/mL BSA and 0.1% sodium azide.

Gene Symbols

BMI1; PCGF4; RNF51

Immunogen

Recombinant Bmi-1 protein corresponding to residues 1-202 of mouse Bmi-1.

Quantity

100 μL

Research Discipline

Epigenetics and Nuclear Function

Gene ID (Entrez)

NP_031578.2

Content And Storage

Stable for one year at 2°C to 8°C from date of receipt.

Isotype

IgG1

Description

  • Specifically detects Bmi-1 clone: F6 in Human, Monkey samples, and it is validated for Immunocytochemistry Polycomb complex protein BMI-1 (UniProt P25916; also known as B lymphoma Mo-MLV insertion region 1, Polycomb group RING finger protein 4) is encoded by the Bmi1 (also known as AW546694, Bmi-1, Pcgf4) gene (Gene ID 12151) in murine species
  • Bmi1 is a member of the polycomb group (PcG) family of evolutionarily conserved gene silencers involved in cell fate decisions and body pattern during development
  • Bmi1 is an important regulator of self-renewal of hematopoietic and neural stem cells, as well as cancer stem cells (CSCs)
  • Bmi1 is a main constituent of the polycomb repressive complex 1 (PRC1) and pariticipates in PRC-mediated gene silencing by promoting monoubiquitination of H2A
  • Bmi1 overexpression is reported in many different human cancers and high level of Bmi1 is considered as a poor prognostic marker
  • Bmi1 targets genes involved in transforming growth factor-β/bone morphogenetic protein (TGF-beta/BMP), endoplasmic reticulum (ER) stress, and WNT pathways
  • Bmi itself is transcriptionally regulated by c-Myc and E2F1 transcription factors.

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Img

MilliporeSigma™

05-637-AF488

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Antigen:
Bmi-1

Classification:
Monoclonal

Conjugate:
Alexa Fluor 488

Gene Accession No.:
P25916

Host Species:
Mouse

Purification Method:
Protein G Purified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Target Species:
Human, Monkey

Form:
Purified

Applications:
Immunocytochemistry

Clone:
F6

Formulation:
Purified mouse conjugate antibody in PBS with 15mg/mL BSA and 0.1% sodium azide.

Gene Symbols:
BMI1; PCGF4; RNF51

Immunogen:
Recombinant Bmi-1 protein corresponding to residues 1-202 of mouse Bmi-1.

Quantity:
100 μL

Research Discipline:
Epigenetics and Nuclear Function

Gene ID (Entrez):
NP_031578.2

Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.

Isotype:
IgG1

Img

MilliporeSigma™

05-637-AF647

--


Antigen:
Bmi-1

Classification:
Monoclonal

Conjugate:
Alexa Fluor 647

Gene Accession No.:
P25916

Host Species:
Mouse

Purification Method:
Protein G Purified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Target Species:
Human, Monkey

Form:
Purified

Applications:
Immunocytochemistry

Clone:
F6

Formulation:
Purified mouse conjugate antibody in PBS with 15mg/mL BSA and 0.1% sodium azide.

Gene Symbols:
Bmi1; Bmi-1; Pcgf4

Immunogen:
Recombinant Bmi-1 protein corresponding to residues 1-202 of mouse Bmi-1.

Quantity:
100 μL

Research Discipline:
Epigenetics and Nuclear Function

Gene ID (Entrez):
NP_031578.2

Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.

Isotype:
IgG1

Img

MilliporeSigma

05-637-MI

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Antigen:
Bmi-1

Classification:
Monoclonal

Conjugate:
Unconjugated

Gene Accession No.:
NM_005180

Host Species:
Mouse

Purification Method:
Protein G purfied

Regulatory Status:
__

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rabbit, Rat

Form:
Purified

Applications:
Immunocytochemistry, Immunoprecipitation, Western Blot

Clone:
F6

Formulation:
Immunoaffinity Purified immunoglobulin in Protein A Purified immunoglobulin in 0.1M Tris-Glycine, 0.15M NaCl, 0.05% sodium azide, pH 7.4.

Gene Symbols:
BMI1, MGC12685, PCGF4, flvi-2/bmi-1, RNF51

Immunogen:
Immunized with recombinant Bmi-1 protein corresponding to residues 1-202 of mouse Bmi-1.

Quantity:
100 μg

Research Discipline:
__

Gene ID (Entrez):
__

Content And Storage:
2-8°C for one year

Isotype:
IgG1

Img

MilliporeSigma

05-656-MI

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Antigen:
IGF-IR

Classification:
Monoclonal

Conjugate:
Unconjugated

Gene Accession No.:
NM_000875

Host Species:
Mouse

Purification Method:
Protein A purfied

Regulatory Status:
__

Primary or Secondary:
Primary

Target Species:
Human, Mouse

Form:
Purified

Applications:
Immunohistochemistry, Immunoprecipitation, Western Blot

Clone:
JBW902

Formulation:
Protein A Purified immunoglobulin in Immunoaffinity Purified immunoglobulin in 0.14MTris-glycine, pH 7.4, 0.105MNaCl, 0.035% sodium azide and 30% glycerol.

Gene Symbols:
IGF1R, IGFIR, MGC18216, MGC142170, JTK13, MGC142172, CD221

Immunogen:
GST fusion protein corresponding to residues 1264-1367 of human IGF-1 Receptor

Quantity:
200 μg

Research Discipline:
__

Gene ID (Entrez):
__

Content And Storage:
−20°C in undiluted aliquots for up to 24 months. Avoid repeated freeze/thaw cycles.

Isotype:
IgG2a