05957IMI
MilliporeSigma™ ERK1/MAPK3, Rabbit, Unlabeled, Clone: UP-158-22-3-10,
Manufacturer: MilliporeSigma™
CAS Number: 158-22-3
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 05957IMI-Each-of-1 | In Stock | ₹ 42,968.31 |
05957IMI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,968.31
GST (18%): ₹ 7,734.296
Total Price: ₹ 50,702.606
Antigen
ERK1/MAPK3
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Rabbit monoclonal antibody IgG hybridoma culture supernatant without preservatives.
Gene Accession No.
P21708
Immunogen
KLH-conjugated linear peptide corresponding to the C-terminal sequence of rat ERK-1 (MAPK 3).
Quantity
100 μL
Research Discipline
Epigenetics & Nuclear Function
Gene ID (Entrez)
NP_059043
Target Species
Human
Form
Culture Supernatant
Applications
Western Blot
Clone
UP-158-22-3-10
Conjugate
Unconjugated
Gene
Mapk3, Erk1, Prkm3
Host Species
Rabbit
Purification Method
Unpurified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone UP-158-22-3-10 recognizes a C-terminal epitope of MAPK 3 (ERK1). Immunogen sequence is not present in human MAPK3 spliced isoform 3 (ERK1b).
Content And Storage
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Description
- Mitogen-activated protein kinase 3 (EC 2.7.11.24; UniProt P21708; also known as ERK-1, ERT2, Extracellular signal-regulated kinase 1, Insulin-stimulated MAP2 kinase, MAP kinase 3, MAP kinase isoform p44, MAPK 3, Microtubule-associated protein 2 kinase, MNK1, p44-ERK1, p44-MAPK) is encoded by the Mapk3 (also known as Erk1, Prkm3) gene (Gene ID 50689) in rat species
- ERK1 (a.k.a
- MAPK 3) and ERK2 (a.k.a
- MAPK 1 or MAPK 2) are related serine/threonine kinases of the Ras-Raf-MEK-ERK signaling pathway
- ERK1/2 are activated by MEK1/2-catalyzed phosphorylation at their conserved Thr-Glu-Tyr (TEY) dual phosphorylation motif, first at the Tyr residue (human/rat ERK1 Tyr204/Tyr203, human/rat ERK2 Tyr187/Tyr183) and then at the Thr residue (human/rat ERK1 Thr202/Thr201, human/rat ERK2 Thr185/Thr181)
- ERK1/2 are proline-directed kinases that preferentially catalyze the phosphorylation of Pro-Xxx-Ser/Thr-Pro sequence motif in hundreds of cytoplasmic and nuclear substrates, including transcription factors such as Ets, Elk, and c-Fos
- Besides this primary structure requirement, many ERK1/2 substrates possess a D-docking site and/or an F-docking site
- A variety of scaffold proteins, including KSR1/2, IQGAP1, MP1, and -Arrestin1/2, also participate in the regulation of ERK1/2 MAP kinase cascade
- Ras-Raf-MEK-ERK signaling activity is upregulated in about one-third of all human cancers, and targeted inhibition against components of this signaling pathway represents a popular anticancer strategy.
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Antigen: ERK1/MAPK3
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Rabbit monoclonal antibody IgG hybridoma culture supernatant without preservatives.
Gene Accession No.: P21708
Immunogen: KLH-conjugated linear peptide corresponding to the C-terminal sequence of rat ERK-1 (MAPK 3).
Quantity: 100 μL
Research Discipline: Epigenetics & Nuclear Function
Gene ID (Entrez): NP_059043
Target Species: Human
Form: Culture Supernatant
Applications: Western Blot
Clone: UP-158-22-3-10
Conjugate: Unconjugated
Gene: Mapk3, Erk1, Prkm3
Host Species: Rabbit
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone UP-158-22-3-10 recognizes a C-terminal epitope of MAPK 3 (ERK1). Immunogen sequence is not present in human MAPK3 spliced isoform 3 (ERK1b).
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Antigen:
ERK1/MAPK3
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Rabbit monoclonal antibody IgG hybridoma culture supernatant without preservatives.
Gene Accession No.:
P21708
Immunogen:
KLH-conjugated linear peptide corresponding to the C-terminal sequence of rat ERK-1 (MAPK 3).
Quantity:
100 μL
Research Discipline:
Epigenetics & Nuclear Function
Gene ID (Entrez):
NP_059043
Target Species:
Human
Form:
Culture Supernatant
Applications:
Western Blot
Clone:
UP-158-22-3-10
Conjugate:
Unconjugated
Gene:
Mapk3, Erk1, Prkm3
Host Species:
Rabbit
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone UP-158-22-3-10 recognizes a C-terminal epitope of MAPK 3 (ERK1). Immunogen sequence is not present in human MAPK3 spliced isoform 3 (ERK1b).
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
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