07-415-IMI
MilliporeSigma™ Rabbit anti-Sam 68, Polyclonal,
Manufacturer: MilliporeSigma™
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 07-415-IMI-Each-of-1 | In Stock | ₹ 41,307.51 |
07-415-IMI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,307.51
GST (18%): ₹ 7,435.352
Total Price: ₹ 48,742.862
Antigen
Sam 68
Classification
Polyclonal
Gene Accession No.
Q60749
Host Species
Rabbit
Purification Method
Unpurified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human, Mouse
Form
Serum
Applications
Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
Formulation
Rabbit polyclonal serum with 0.05% sodium azide.
Gene Symbols
Khdrbs1
Immunogen
KLH-conjugated peptide corresponding to amino acid residues 331-348 of human Sam 68
Quantity
200 μL
Research Discipline
Signaling
Gene ID (Entrez)
NP_035447
Content And Storage
Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
Description
- Specifically detects Sam 68 in Human, Mouse samples, and it is validated for Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blotting KH domain-containing, RNA-binding, signal transduction-associated protein 1 (UniProt Q60749; also known as GAP-associated tyrosine phosphoprotein p62, Khdrbs1,p68, p21 Ras GTPase-activating protein-associated p62, Sam68, Src-associated in mitosis 68kDa protein) is encoded by the Khdrbs1 gene (Gene ID 20218) in murine species
- Sam68 is a member of the 'signal transduction and activation of RNA' (STAR) family of KH domain-containing RNA-binding proteins that mediates pre-mRNA splicing, mRNA export, and protein translation
- It binds to UAAA, UUUA, and UUUUUU motifs with high affinity
- RNA immunoprecipitation (RIP) techniques using lysates from UV cross-linked NIH 3T3 cells have identified 23 Sam68 complex-associated mRNA species, including Thrap1, bri3bp, Myl6, Copeb/KLF6/Zf9, Hmgn1, Smc6, and biglycan
- In addition, Sam68 is found to be a key regulator of Nrxn1 alternative splicing in the central nervous system in a neuronal activity-dependent manner
- Sam68 is phosphorylated on three tyrosine residues (pTyr435, pTyr440, and pTyr443) within the C-terminal nuclear localization signal (NLS) region by the breast tumor kinase (BRK) following EGF stimulation of breast tumor cells with pTyr440 being a principal modulator of Sam68 nuclear localization
- Studies comparing wild-type and Sam68-/- knockout mice revealed a positive regulatory role of Sam68 toward adipocyte differentiation, as well as a negative impact of Sam68 against osteoblast differentiation among aged mice.
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Antigen: Sam 68
Classification: Polyclonal
Gene Accession No.: Q60749
Host Species: Rabbit
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human, Mouse
Form: Serum
Applications: Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
Formulation: Rabbit polyclonal serum with 0.05% sodium azide.
Gene Symbols: Khdrbs1
Immunogen: KLH-conjugated peptide corresponding to amino acid residues 331-348 of human Sam 68
Quantity: 200 μL
Research Discipline: Signaling
Gene ID (Entrez): NP_035447
Content And Storage: Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
Antigen:
Sam 68
Classification:
Polyclonal
Gene Accession No.:
Q60749
Host Species:
Rabbit
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Form:
Serum
Applications:
Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
Formulation:
Rabbit polyclonal serum with 0.05% sodium azide.
Gene Symbols:
Khdrbs1
Immunogen:
KLH-conjugated peptide corresponding to amino acid residues 331-348 of human Sam 68
Quantity:
200 μL
Research Discipline:
Signaling
Gene ID (Entrez):
NP_035447
Content And Storage:
Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
Antigen: Sam 68
Classification: Polyclonal
Gene Accession No.: __
Host Species: Rabbit
Purification Method: Antiserum
Regulatory Status: __
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Form: Serum
Applications: Immunocytochemistry, Immunoprecipitation, Western Blot
Formulation: 0.1M Trisglycine,pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Gene Symbols: KHDRBS1; Sam68; FLJ34027; SAM68; p68; p62
Immunogen: Peptide corresponding to residues 331-348 of human Sam 68
Quantity: 200 μL
Research Discipline: __
Gene ID (Entrez): NM_006559
Content And Storage: −20°C for 24 months
Antigen:
Sam 68
Classification:
Polyclonal
Gene Accession No.:
__
Host Species:
Rabbit
Purification Method:
Antiserum
Regulatory Status:
__
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Form:
Serum
Applications:
Immunocytochemistry, Immunoprecipitation, Western Blot
Formulation:
0.1M Trisglycine,pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Gene Symbols:
KHDRBS1; Sam68; FLJ34027; SAM68; p68; p62
Immunogen:
Peptide corresponding to residues 331-348 of human Sam 68
Quantity:
200 μL
Research Discipline:
__
Gene ID (Entrez):
NM_006559
Content And Storage:
−20°C for 24 months
Antigen: __
Classification: __
Gene Accession No.: __
Host Species: __
Purification Method: __
Regulatory Status: __
Primary or Secondary: __
Target Species: __
Form: __
Applications: __
Formulation: __
Gene Symbols: __
Immunogen: __
Quantity: __
Research Discipline: __
Gene ID (Entrez): __
Content And Storage: __
Antigen:
__
Classification:
__
Gene Accession No.:
__
Host Species:
__
Purification Method:
__
Regulatory Status:
__
Primary or Secondary:
__
Target Species:
__
Form:
__
Applications:
__
Formulation:
__
Gene Symbols:
__
Immunogen:
__
Quantity:
__
Research Discipline:
__
Gene ID (Entrez):
__
Content And Storage:
__
Antigen: SHP-1/SHPTP-1
Classification: Polyclonal
Gene Accession No.: __
Host Species: Rabbit
Purification Method: Protein A purfied
Regulatory Status: __
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Applications: Immunoprecipitation, Western Blot
Formulation: 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide
Gene Symbols: PTPN6; HCP; SH-PTP1; PTP-1C; SHP1; SHP-1L; PTP1C; HCPH; SHP-1; HPTP1C
Immunogen: Full-length glutathione transferase SHP-1 fusion protein, purified from bacteria
Quantity: 200 μg
Research Discipline: __
Gene ID (Entrez): NM_002831
Content And Storage: 2-8°C for 12 months
Antigen:
SHP-1/SHPTP-1
Classification:
Polyclonal
Gene Accession No.:
__
Host Species:
Rabbit
Purification Method:
Protein A purfied
Regulatory Status:
__
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Applications:
Immunoprecipitation, Western Blot
Formulation:
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide
Gene Symbols:
PTPN6; HCP; SH-PTP1; PTP-1C; SHP1; SHP-1L; PTP1C; HCPH; SHP-1; HPTP1C
Immunogen:
Full-length glutathione transferase SHP-1 fusion protein, purified from bacteria
Quantity:
200 μg
Research Discipline:
__
Gene ID (Entrez):
NM_002831
Content And Storage:
2-8°C for 12 months