MilliporeSigma™ GLUT-2, Rabbit, Unlabeled, Polyclonal,

Description

• Solute carrier family 2, facilitated glucose transporter member 2 (UniProt P14246; also known as Glucose transporter type 2, liver, GLUT-2) is encoded by the Slc2a2 (also known as Glut-2, Glut2) gene (Gene ID 20526) in murine species
• GLUTs (Glucose transporters) are a family of integral membrane glycoproteins that facilitative glucose uptake by cells
• Molecular cloning of glucose transporters have identified a family of closely related genes that encode at least 7 proteins exhibiting high degree of homology (45% to 65%)
• GLUT2 is a facilitative glucose transporter that mediates the bidirectional transfer of glucose across the hepatocyte membrane
• It is present at high levels in the plasma membrane of pancreatic beta cells where it initiates the first step in glucose-stimulated insulin secretion
• Due to its low affinity and high capacity, GLUT2 transports dietary sugars, glucose, fructose and galactose in a large range of physiological concentrations, displaying large bidirectional fluxes in and out the cells
• It also participates in the transport of glucose in small intestine and kidney along with the Na+/glucose cotransporter
• Hepatic GLUT2 expression is upregulated in a dose-dependent manner according to glucose concentration in primary hepatocytes and hepatocyte cell lines
• Also, hepatic GLUT2 expression is reduced during starvation and returns to normal levels after refeeding
• In diabetic animals, hepatic GLUT2 expression is increased, but is corrected to normal levels when hyperglycemic conditions are corrected by exogenous insulin
• Ref.: Burkhardt, BR., et al
• (2005)
• FEBS Lett
• 579, 5759 5764.