MilliporeSigma™ Rac2, Rabbit, Unlabeled, Polyclonal,

Description

• Ras-related C3 botulinum toxin substrate 2 (UniProt P15153; also known as GX, p21-Rac2, Small G protein) is encoded by the RAC2 gene (Gene ID 5880) in human
• Rho family of small GTPases are involved in a wide variety of cellular functions such as cell polarity, vesicular trafficking, and cell cycle by regulating intracellular actin dynamics
• In mammals, the Rho family contains 22 members which can be further divided into the Rac subfamily (Rac1, Rac2, Rac3, and RhoG), Cdc42 subfamily (Cdc42, TC10, TCL, Chip, and Wrch-1), RhoA subfamlly (RhoA, RhoB, and RhoC) and other Rho-GTPases (RhoE/Rnd3, RhoH/TTF, Rif, RhoBTB1, RhoBTB2, Miro-1, Miro-2, RhoD, Rnd1, and Rnd2)
• Rac1 and Rac2 share high sequence homology (90%) and are both expressed in the hematopoietic system, where they play crucial roles in mediating the interactions between hematopoietic stem cells (HSCs) and their microenvironment
• Rac proteins transduce cell surface signaling events initiated by tyrosine kinase receptors, G protein-coupled receptors, and cell-to-cell contacts by acting as molecular switches, cycling between an inactive GDP-bound state and a GTP-bound active state
• In addition to overlapping functions, Rac1 and Rac2 also mediate unique functions via interactions with specific partners
• SAM50 and Metaxin1, for example, are among mitochondrial proteins identified to be specifically associated with Rac2
• Rac activity inhibition is reported to effectively target primary human AML and CML cells and prevent disease initiation in various murine leukemia models.