MilliporeSigma™ phospho-JAK1 (Tyr1022/1023), Rabbit, Unlabeled, Polyclonal,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 07849I-Each-of-1 | In Stock | ₹ 40,197.80 |
07849I - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,197.80
GST (18%): ₹ 7,235.604
Total Price: ₹ 47,433.404
Antigen
phospho-JAK1 (Tyr1022/1023)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
JAK1, JAK1A, JAK1B
Host Species
Rabbit
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
The Tyr1022/1023 designation is according to the JAK1 sequence originally published by Wilks, A.F., et al. (1991). Mol. Cell. Biol. 11(4):2057-2065 (PMID 1848670; NCBI accession: AAA36527). Numbering of the target pTyr residues varies depending on the species and source of the sequence. For example, target pTyr residues this rabbit polyclonal detects correspond to pTyr1034/pTyr1035 and pTyr1033/pTyr1034, respectively, of the human and mouse JAK1 sequence reported by UniProt (P23458 and P52332, respectively), or pTyr1033/pTyr1034 of bovine, canine, and rat JAK1 (NP_001193463 and NP_445918.1), pTyr1021/pTyr1022 of porcine JAK1 (NP_999279).
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Applications
Western Blot
Concentration
Please refer to lot specific datasheet.
Formulation
Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
P23458
Immunogen
KLH-conjugated phosphopeptide corresponding to the epitope reqeion sequence containing the two phosphorylated target tyrosine residues.
Quantity
100 μL
Research Discipline
Signaling
Gene ID (Entrez)
NP_002218
Target Species
Human
Description
- Merlin (UniProt P35240; also known as Moesin-ezrin-radixin-like protein, Neurofibromin-2, Schwannomerlin, Schwannomin) is encoded by the NF2 (also known as SCH) gene (Gene ID 4771) in human
- Originally identified as a tumor suppressor gene in the familial Neurofibromatosis type 2 (NF2) cancer patients, NF2 encodes the FERM (Ezrin, Radixin, Moesin) domain-containing merlin that plays a negative regulating role against cell growth and proliferation by functioning as an upstream activator of the Hippo pathway
- Merlin directly activates Mst1/2 and recruits Lats1/2 to the plasma membrane for phosphorylation by Mst1/2
- The phosphorylated Lats1/2 in turn inhibits YAP/TAZ transcription activity by phosphorylating YAP/TAZ and causes its cytoplasmic sequestration
- Merlin also translocates to the nucleus, where it inhibits E3 ubiquitin ligase CRL4(DCAF1), thereby preventing it from ubiquitinating and downregulating Lats1/2
- In its inactive state, the C-terminal tail domain (CTD; a.a
- 507-595) of merlin is bound intramolecularly to its FERM domain (a.a
- 19-313)
- Angiomotin (AMOT) induces merlin activation by binding to an elongated helical fragment within merlin CTD and subsequently releases the auto-inhibited conformation of Merlin
- Merlin CTD can also undergo phosphorylation on Ser518 by p21-activated kinase (PAK) or cyclic AMP-dependent protein kinase (PKA), resulting in a weakened AMOT binding and a stabilization of merlin in its auto-inhibited state.
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Antigen: phospho-JAK1 (Tyr1022/1023)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: JAK1, JAK1A, JAK1B
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: The Tyr1022/1023 designation is according to the JAK1 sequence originally published by Wilks, A.F., et al. (1991). Mol. Cell. Biol. 11(4):2057-2065 (PMID 1848670; NCBI accession: AAA36527). Numbering of the target pTyr residues varies depending on the species and source of the sequence. For example, target pTyr residues this rabbit polyclonal detects correspond to pTyr1034/pTyr1035 and pTyr1033/pTyr1034, respectively, of the human and mouse JAK1 sequence reported by UniProt (P23458 and P52332, respectively), or pTyr1033/pTyr1034 of bovine, canine, and rat JAK1 (NP_001193463 and NP_445918.1), pTyr1021/pTyr1022 of porcine JAK1 (NP_999279).
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Applications: Western Blot
Concentration: Please refer to lot specific datasheet.
Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: P23458
Immunogen: KLH-conjugated phosphopeptide corresponding to the epitope reqeion sequence containing the two phosphorylated target tyrosine residues.
Quantity: 100 μL
Research Discipline: Signaling
Gene ID (Entrez): NP_002218
Target Species: Human
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Purification Method: __
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Content And Storage: __
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Immunogen: __
Quantity: __
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