CD257 (BAFF, BLyS) Monoclonal Antibody (1D6), FITC, eBioscience™, Invitrogen™

Description

• The 1D6 MAb reacts with human BLyS (B lymphocyte stimulator), also known as BAFF (B cell activating factor from the TNF family), TALL-1 (TNF and apoptosis leukocyte-expressed ligand-1), THANK (TNF homologue that activates apoptosis, nuclear factor KappaB and c-Jun NH2-terminal kinase) and zTNF4
• BLyS, a member of the TNF family, is a type II membrane protein that exists in both membrane-bound and soluble forms
• Expression of membrane-bound BLyS on monocytes lineage is regulated by IFN-gamma
• BLyS acts as a potent B cell growth factor and costimulator of Ig production
• BLyS transgenic mice develop severe B cell hyperplasia and autoimmune lupus-like disease characterized by the presence of autoantibodies against nuclear antigens and immune complexes deposited in the kidney
• Data from animal models imply a role for BLyS in human autoimmune diseases
• To date BCMA, TACI and BR3 have been identified as receptors for BLyS
• APRIL, another TNF family member, and BLyS can form active heterotrimeric molecules when coexpressed and these circulating heterotrimers are present in serum samples from patients with systemic immune-based rheumatic diseases
• Furthermore, it has been reported that BLyS and APRIL, share BCMA and TACI as their receptors
• BAFF is a membrane bound cytokine expressed by B cell lineage cells
• The soluble form of the cytokine binds to the receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR
• BAFF is a potent B cell activator, and important for the proliferation and differentiation of B cells
• BAFF is also expressed by T lymphocytes and has been shown to promote T cell activation and survival
• Isoforms representing alternatively spliced, and glycosylated variants have been identified.