RAE1 gamma Monoclonal Antibody (CX1), PE, eBioscience™, Invitrogen™

Description

• The CX1 MAb reacts with the mouse retinoic acid early inducible gamma (RAE-1gamma) and weakly cross-reacts with the RAE-1alpha and beta, but not with delta and ε
• These 5 members of the RAE-1 family, along with another protein encoded by the minor histocompatibility gene complex called H60 have been identified as ligands for the mouse NKG2D molecule
• These ligands are normally absent from adult tissue, however the presence of retinoic acid or certain disease conditions (such as tumors) can induce up-regulation of this protein at the cell surface
• RAE-1alpha, -beta, and -gamma and H60 are expressed in BALB/c mice, but not in C57BL/6, whereas RAE-1delta, and -ε are expressed in C57BL/6 mice
• It is reported that in NOD mice, both NKG2D and its ligand RAE-1 are expressed on the same NK cells, resulting in self-modulation of NKG2D expression and function
• Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export
• The protein encoded by this gene is a homolog of yeast Rae1
• It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm
• This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton
• Alternatively spliced transcript variants encoding the same protein have been found for this gene.