IL-37 Monoclonal Antibody (37D12), Biotin, eBioscience™, Invitrogen™

Description

• Description: This 37D12 monoclonal antibody reacts with human IL-37
• IL-37 is a member of the interleukin 1 cytokine family and is also known as IL-1F7 and IL-1H4
• IL-37 suppresses innate inflammatory and immune responses and exhibits anti-inflammatory characteristics resembling those of IL-1R8
• IL-37 binds to the alpha chain of IL-18R with low affinity and does not recruit the essential signaling co-receptor IL-18 beta or mediate pro-inflammatory activity
• IL-37 also binds to IL-18 binding protein (IL-18BP) and enhances the antagonistic effects of IL-18BP
• IL-37 forms a trimeric complex with IL-18BP and IL-18R beta, which results in the blockade of IL-18 activity
• Transcripts of IL-37 have been detected in human tissues, such as lung, testis, and colon tumors, as well as some human cell lines
• Applications Reported: This 37D12 antibody has been reported for use in immunocytochemistry followed by cytospin
• Applications Tested: This 37D12 antibody has been tested by immunocytochemistry of fixed and permeabilized normal human peripheral blood mononuclear cells and can be used at less than or equal to 20 μg/mL
• It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest
• Filtration: 0.2 μm post-manufacturing filtered
• The protein encoded by this gene is a member of the interleukin 1 cytokine family
• This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp)
• This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18
• This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2
• Five alternatively spliced transcript variants encoding distinct isoforms have been reported.