Connexin 26 Monoclonal Antibody (CX-12H10), Invitrogen™

Description

• 13-8100 reacts strongly with Connexin-26, which has a predicted molecular weight of 26.5 kDa
• Reactivity of this antibody on western blots has been confirmed by using extracts from mouse liver, mouse brain, and rat brain and it appears to exhibit minimal cross-reaction with Cx30 by western blotting
• The degree of cross-reaction with Cx30 by IHC is uncertain, but may be influenced by fixation conditions
• Gap junctions are conduits that allow the direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular metabolic and electrical communication
• Gap junction channels consist of connexin protein subunits, which are encoded by a multigene family
• GJBs (gap-junction proteins or connexins) play crucial functional roles associated with these channels
• Defects in GJB3 have been linked to erythrokeratodermia variables (EKV) is an autosomal dominant genodermatosis characterized by transient figurate red patches or hyperkeratosis
• Mutations in GJB2 have also been associated with genetically derived hearing impairments, including autosomal recessive nonsyndromic deafness.