CD36 Monoclonal Antibody (eBioNL07 (NL07)), eBioscience™, Invitrogen™

Description

• The MAb eBioNL07 recognizes human CD36, which is a member of the class B scavenger receptor family
• CD36 was originally identified as a platelet-membrane glycoprotein also called glycoprotein IV and a receptor for thrombospondin-1 (TSP-1) and extracellular matrix proteins
• Binding to TSP-1 is in the CLESH (CD36 LIMP-II Emp sequence homology) domain of CD36
• CD36 expression is broad and includes microvascular (but not large vessel) endothelium, adipocytes, skeletal muscle, dendritic cells, epithelia of the retina, breast, and intestine, smooth muscle cells, and hematopoietic cells, including erythroid precursors, platelets, monocytes/macrophages, DCs and megakaryocytes
• Expression on platelets is absent on Nak^a negative donors
• Unlike other scavenger receptor, CD36 binds LDL that has been exposed to minimally oxidizing conditions
• CD36 is also a fatty acid translocase (FAT) necessary for the transport of long-chain fatty acids (LCFAs) and therefore may play a role in atherosclerosis
• CD36, also known as scavenger receptor class B member 3, is a protein that is expressed on the surface of various cell types, including macrophages, platelets, and adipocytes
• It plays a role in lipid metabolism, inflammation, and atherosclerosis, and is involved in the recognition and uptake of various ligands such as oxidized low-density lipoproteins, long-chain fatty acids, and apoptotic cells
• CD36 is also implicated in the pathogenesis of malaria
• The protein encoded by this gene serves as a receptor for thrombospondin in platelets and various cell lines, and is the fourth major glycoprotein of the platelet surface
• It binds to collagen, thrombospondin, anionic phospholipids, and oxidized LDL, and directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes
• Mutations in this gene cause platelet glycoprotein deficiency
• Multiple alternatively spliced transcript variants have been found for this gene
• Diseases associated with CD36 include Platelet Glycoprotein IV Deficiency and Coronary Heart Disease 7.