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200006782

CD8a Monoclonal Antibody (RPA-T8), Brilliant Violet™ 605, eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

CD8a

Concentration

5 μL/Test

Classification

Monoclonal

Form

Liquid

Regulatory Status

RUO

Formulation

PBS with BSA and 0.09% sodium azide, pH 7.2

Gene Alias

BB154331, CD8, CD8 alpha, CD8 alpha chain, CD8 alpha chain precursor, CD8 antigen, CD8 antigen 32 kDa chain, CD8 antigen 37 kDa chain, CD8 antigen alpha polypeptide, CD8 antigen alpha protein, CD8 antigen alpha protein precursor, CD8 antigen alpha-chain, CD8 antigen beta polypeptide, CD8 antigen beta polypeptide precursor, CD8 antigen beta-chain, CD8 antigen, alpha chain, CD8 antigen, alpha polypeptide, CD8 antigen, alpha polypeptide (p32), CD8 antigen, alpha-chain, CD8 antigen, beta chain, CD8 antigen, beta chain 1, CD8 antigen, beta polypeptide, CD8 antigen, beta polypeptide 1 (p37), CD8 antigen, beta-chain, CD8 beta, CD8 beta chain, CD8 beta-2, CD8a, CD8A antigen alpha, CD8a molecule, CD8A, T-cell surface glycoprotein, CD8alpha, CD8B, CD8b antigen, CD8b molecule, CD8b molecule pseudogene, Cd8b1, CD8beta, CD8BP, fCD8, LEU2, Leu-2, Leu2 T-lymphocyte antigen, leu-2a, Ly-2, LY3, Ly-3, Ly-35, Ly-B, Ly-C, Lymphocyte antigen 3, Lyt2, Lyt-2, Lyt-2.1 lymphocyte differentiation antigen (AA at 100), Lyt3, Lyt-3, MAL, membrane glycoprotein, membrane protein, OKT8 T-cell antigen, OX-8 membrane antigen, p32, P37, RHACD8-4, T cell co-receptor, T lymphocyte surface glycoprotein beta chain, T8 T-cell antigen, T-cell antigen Leu2, T-cell membrane glycoprotein Ly-3, T-cell surface glycoprotein, T-cell surface glycoprotein CD8 alpha chain, T-cell surface glycoprotein CD8 beta chain, T-cell surface glycoprotein Lyt-2, T-cell surface glycoprotein Lyt-3, T-cell surface molecule, T-lymphocyte differentiation antigen T8/Leu-2, type I transmembrane glycoprotein

Gene Symbols

Cd8a, CD8B

Primary or Secondary

Primary

Content And Storage

4° C, store in dark, DO NOT FREEZE!

Clone

RPA-T8

Applications

Flow Cytometry

Conjugate

Brilliant Violet 605

Host Species

Mouse

Target Species

Human

Gene Accession No.

P01732, P10966

Gene ID (Entrez)

925, 926

Isotype

IgG1 κ

Purification Method

Affinity chromatography

Gene

CD8B

Description

  • Cluster of differentiation 8 (CD8), a type I transmembrane glycoprotein of the immunoglobulin family of receptors, plays an integral role in signal transduction, and T cell differentiation and activation
  • CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8alpha and CD8beta, where it functions as a co-receptor, along with T cell receptor (TCR), for major histocompatibilty complex class I (MHC-I) molecules; whereas its counterpart, CD4, acts as a co-receptor for MHC-II molecules
  • CD8 exists on the cell surface, where the CD8alpha chain is essential for binding to MHC-I
  • CD8 is also expressed on a subset of T cells, NK cells, monocytes and dendritic cells as disulfide-linked homodimers of CD8alpha
  • Ligation of MHC-I/peptide complexes presented by antigen-presenting cells (APCs), triggers the recruitment of lymphocyte-specific protein tyrosine kinase (Lck), which leads to lymphokine production, motility and cytotoxic T lymphocyte (CTL) activation
  • Once activated, CTLs play a crucial role in the clearance of pathogens and tumor cells
  • Differentiation of naive CD8+ T cells into CTLs is strongly enhanced by IL-2, IL-12 and TGF-beta1.

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Fischer Scientific

200006782

Mouse Monoclonal Antibody...

Antigen:
CD8a
Concentration:
5 μL/Test
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with BSA and 0.09% sodium azide, pH 7.2
Gene Alias:
BB154331, CD8, CD8 alpha, CD8 alpha chain, CD8 alpha chain precursor, CD8 antigen, CD8 antigen 32 kDa chain, CD8 antigen 37 kDa chain, CD8 antigen alpha polypeptide, CD8 antigen alpha protein, CD8 antigen alpha protein precursor, CD8 antigen alpha-chain, CD8 antigen beta polypeptide, CD8 antigen beta polypeptide precursor, CD8 antigen beta-chain, CD8 antigen, alpha chain, CD8 antigen, alpha polypeptide, CD8 antigen, alpha polypeptide (p32), CD8 antigen, alpha-chain, CD8 antigen, beta chain, CD8 antigen, beta chain 1, CD8 antigen, beta polypeptide, CD8 antigen, beta polypeptide 1 (p37), CD8 antigen, beta-chain, CD8 beta, CD8 beta chain, CD8 beta-2, CD8a, CD8A antigen alpha, CD8a molecule, CD8A, T-cell surface glycoprotein, CD8alpha, CD8B, CD8b antigen, CD8b molecule, CD8b molecule pseudogene, Cd8b1, CD8beta, CD8BP, fCD8, LEU2, Leu-2, Leu2 T-lymphocyte antigen, leu-2a, Ly-2, LY3, Ly-3, Ly-35, Ly-B, Ly-C, Lymphocyte antigen 3, Lyt2, Lyt-2, Lyt-2.1 lymphocyte differentiation antigen (AA at 100), Lyt3, Lyt-3, MAL, membrane glycoprotein, membrane protein, OKT8 T-cell antigen, OX-8 membrane antigen, p32, P37, RHACD8-4, T cell co-receptor, T lymphocyte surface glycoprotein beta chain, T8 T-cell antigen, T-cell antigen Leu2, T-cell membrane glycoprotein Ly-3, T-cell surface glycoprotein, T-cell surface glycoprotein CD8 alpha chain, T-cell surface glycoprotein CD8 beta chain, T-cell surface glycoprotein Lyt-2, T-cell surface glycoprotein Lyt-3, T-cell surface molecule, T-lymphocyte differentiation antigen T8/Leu-2, type I transmembrane glycoprotein
Gene Symbols:
Cd8a, CD8B
Primary or Secondary:
Primary
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Clone:
RPA-T8
Applications:
Flow Cytometry
Conjugate:
Brilliant Violet 605
Host Species:
Mouse
Target Species:
Human
Gene Accession No.:
P01732, P10966
Gene ID (Entrez):
925, 926
Isotype:
IgG1 κ
Purification Method:
Affinity chromatography
Gene:
CD8B

Img

Fischer Scientific

200006783

Rat Monoclonal Antibody...

Antigen:
Ly-6A/E (Sca-1)
Concentration:
0.2 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with BSA and 0.09% sodium azide, pH 7.2
Gene Alias:
9804, locus A/E, Locus AE, Ly6, Ly67, Ly6a, Ly-6A.2, Ly-6A.2/Ly-6E.1, Ly6A/E, Ly-6A/E, ly6a-e, Ly6e, Ly-6E, Ly-6E.1, lymphocyte antigen 6 complex, lymphocyte antigen 6 complex, locus A, lymphocyte antigen 6 complex, locus E, lymphocyte antigen 6A-2/6E-1, Lymphocyte antigen 6E, RIG-E, Sca1, Sca-1, Sca-2, stem cell antigen 1, Stem cell antigen 2, TAP, T-cell-activating protein, thymic shared antigen 1, Tsa1, TSA-1
Gene Symbols:
Ly6a, Ly6e
Primary or Secondary:
Primary
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Clone:
D7
Applications:
Flow Cytometry
Conjugate:
Brilliant Violet 605
Host Species:
Rat
Target Species:
Mouse
Gene Accession No.:
P05533, Q64253
Gene ID (Entrez):
110454, 17069
Isotype:
IgG2a κ
Purification Method:
Affinity chromatography
Gene:
__

Img

Fischer Scientific

200006783

Rat Monoclonal Antibody...

Antigen:
Ly-6A/E (Sca-1)
Concentration:
0.2 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with BSA and 0.09% sodium azide, pH 7.2
Gene Alias:
9804, locus A/E, Locus AE, Ly6, Ly67, Ly6a, Ly-6A.2, Ly-6A.2/Ly-6E.1, Ly6A/E, Ly-6A/E, ly6a-e, Ly6e, Ly-6E, Ly-6E.1, lymphocyte antigen 6 complex, lymphocyte antigen 6 complex, locus A, lymphocyte antigen 6 complex, locus E, lymphocyte antigen 6A-2/6E-1, Lymphocyte antigen 6E, RIG-E, Sca1, Sca-1, Sca-2, stem cell antigen 1, Stem cell antigen 2, TAP, T-cell-activating protein, thymic shared antigen 1, Tsa1, TSA-1
Gene Symbols:
Ly6a, Ly6e
Primary or Secondary:
Primary
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Clone:
D7
Applications:
Flow Cytometry
Conjugate:
Brilliant Violet 605
Host Species:
Rat
Target Species:
Mouse
Gene Accession No.:
P05533, Q64253
Gene ID (Entrez):
110454, 17069
Isotype:
IgG2a κ
Purification Method:
Affinity chromatography
Gene:
__

Img

Fischer Scientific

200006784

Mouse Monoclonal Antibody...

Antigen:
Ki-67
Concentration:
5 μL/Test
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with BSA and 0.09% sodium azide, pH 7.2
Gene Alias:
antigen identified by monoclonal antibody Ki 67, antigen identified by monoclonal antibody Ki-67, Antigen identified by monoclonal antibody Ki-67 homolog, Antigen KI-67, Antigen KI-67 homolog, antigen KI-67, proliferation marker protein Ki-67, antigen KI-67-like, cb31, D630048A14Rik, I79_022666, Ki67, Ki-67, KIA, LOW QUALITY PROTEIN: proliferation marker protein Ki-67, marker of proliferation Ki-67, MIB-, MIB-1, Mki67, PPP1R105, Proliferation marker protein Ki-67, proliferation-related Ki-67 antigen, protein phosphatase 1, regulatory subunit 105, RP11-380J17.2, sb:cb31, si:ch211-250b22.7, unnamed protein product, wu:fa11g09, wu:fb57a07, wu:fi14e05
Gene Symbols:
Mki67
Primary or Secondary:
Primary
Content And Storage:
__
Clone:
20Raj1
Applications:
Flow Cytometry
Conjugate:
Brilliant Violet 605
Host Species:
Mouse
Target Species:
Canine, Human
Gene Accession No.:
P46013
Gene ID (Entrez):
100686578, 4288
Isotype:
IgG1 κ
Purification Method:
Affinity chromatography
Gene:
Mki67