200020046
Histone H2A.X Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Histone H2A.X
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Conjugate
Unconjugated
Host Species
Rabbit
Target Species
Human, Mouse
Gene Accession No.
P16104, P27661
Gene ID (Entrez)
15270, 3014
Immunogen
Recombinant Human H2AFX protein, Ser2-Tyr143 (Accession #P16104)
Primary or Secondary
Primary
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Concentration
0.5 mg/mL
Classification
Polyclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 50% glycerol and 0.05% Proclin 300, pH 7.4
Gene Alias
AW228881, gamma H2AX, gammaH2ax, H2A histone family member X, H2A histone family, member X, H2A.X, H2A.X variant histone, H2A/X, h2afx, H2ax, H2AX histone, Hist5-2ax, histone 5 protein 2ax, histone H2A.x, Histone H2a/x, Histone H2AX, RGD1566119, similar to H2A histone family, member X, zgc:56329
Gene Symbols
H2AX
Isotype
IgG
Purification Method
Protein A
Gene
H2AX
Related Products
Description
- Description Histone H2A.X (H2AX) is a member of the histone H2A family which is one of the four core histones making up the nucleosome core particle
- In eukaryotes, DNA double strand breaks (DSBs) have been shown to trigger the phosphorylation of serine 139 at the carboxy terminus of histone H2AX resulting in gamma-H2AX
- The phosphorylation of H2AX can be detected by Western blotting or immunofluorescence, revealing the frequency of DSBs
- The phosphatidylinositol 3-kinases have been implicated in H2AX phosphorylation, but it is unclear if ATM is the primary H2AX kinase or if other members of the family such as DNA-PK and ATR contribute in a similar manner
- Structurally, H2A.x contains 143 amino acid residues
- Histone H2A.X is considered a basal histone, being synthesized in G1 as well as in S-phase, and its mRNA contains polyA addition motifs and a polyA tail along with the conserved stem-loop and U7 binding sequences involved in the processing and stability of replication type histone mRNAs
- There are two forms of Histone H2A.X mRNA, one about 1600 bases long and contains polyA; the other about 575 bases long, lacking polyA
- The short form behaves as a replication type histone mRNA, while the longer behaves as a basal type histone mRNA
- Histone H2A.X maps to the 11q23.2-q23.3 region of the human chromosome
- Histone H2A.x contributes to histone-formation and therefore the structure of DNA
- Histone H2A variant H2A.x specifically regulates the interaction of MDC1 (mediator of DNA damage checkpoint protein 1), a DNA repair protein to the sites of DNA damage.
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Antigen: Histone H2A.X
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Conjugate: Unconjugated
Host Species: Rabbit
Target Species: Human, Mouse
Gene Accession No.: P16104, P27661
Gene ID (Entrez): 15270, 3014
Immunogen: Recombinant Human H2AFX protein, Ser2-Tyr143 (Accession #P16104)
Primary or Secondary: Primary
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Concentration: 0.5 mg/mL
Classification: Polyclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 50% glycerol and 0.05% Proclin 300, pH 7.4
Gene Alias: AW228881, gamma H2AX, gammaH2ax, H2A histone family member X, H2A histone family, member X, H2A.X, H2A.X variant histone, H2A/X, h2afx, H2ax, H2AX histone, Hist5-2ax, histone 5 protein 2ax, histone H2A.x, Histone H2a/x, Histone H2AX, RGD1566119, similar to H2A histone family, member X, zgc:56329
Gene Symbols: H2AX
Isotype: IgG
Purification Method: Protein A
Gene: H2AX
Antigen:
Histone H2A.X
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Conjugate:
Unconjugated
Host Species:
Rabbit
Target Species:
Human, Mouse
Gene Accession No.:
P16104, P27661
Gene ID (Entrez):
15270, 3014
Immunogen:
Recombinant Human H2AFX protein, Ser2-Tyr143 (Accession #P16104)
Primary or Secondary:
Primary
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Concentration:
0.5 mg/mL
Classification:
Polyclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 50% glycerol and 0.05% Proclin 300, pH 7.4
Gene Alias:
AW228881, gamma H2AX, gammaH2ax, H2A histone family member X, H2A histone family, member X, H2A.X, H2A.X variant histone, H2A/X, h2afx, H2ax, H2AX histone, Hist5-2ax, histone 5 protein 2ax, histone H2A.x, Histone H2a/x, Histone H2AX, RGD1566119, similar to H2A histone family, member X, zgc:56329
Gene Symbols:
H2AX
Isotype:
IgG
Purification Method:
Protein A
Gene:
H2AX
Antigen: CYP3A7
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Conjugate: Unconjugated
Host Species: Rabbit
Target Species: Human, Mouse, Rat
Gene Accession No.: P24462
Gene ID (Entrez): 1551
Immunogen: Recombinant Human CYP3A7 protein, Pro344-Asp497 (Accession #P24462)
Primary or Secondary: Primary
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Concentration: 0.5 mg/mL
Classification: Polyclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 50% glycerol and 0.05% Proclin 300, pH 7.4
Gene Alias: aryl hydrocarbon hydroxylase, CP37, CYP3A7, CYPIIIA7, Cytochrome P450 3A7, cytochrome P450 family 3 subfamily A member 7, cytochrome P450, family 3, subfamily A, polypeptide 7, cytochrome P450, subfamily IIIA, polypeptide 7, cytochrome P450-HFLA, flavoprotein-linked monooxygenase, microsomal monooxygenase, P-450(HFL33), P-450111A7, P450-HFLA, P450HLp2, xenobiotic monooxygenase
Gene Symbols: CYP3A7
Isotype: IgG
Purification Method: Protein A
Gene: CYP3A7
Antigen:
CYP3A7
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Conjugate:
Unconjugated
Host Species:
Rabbit
Target Species:
Human, Mouse, Rat
Gene Accession No.:
P24462
Gene ID (Entrez):
1551
Immunogen:
Recombinant Human CYP3A7 protein, Pro344-Asp497 (Accession #P24462)
Primary or Secondary:
Primary
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Concentration:
0.5 mg/mL
Classification:
Polyclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 50% glycerol and 0.05% Proclin 300, pH 7.4
Gene Alias:
aryl hydrocarbon hydroxylase, CP37, CYP3A7, CYPIIIA7, Cytochrome P450 3A7, cytochrome P450 family 3 subfamily A member 7, cytochrome P450, family 3, subfamily A, polypeptide 7, cytochrome P450, subfamily IIIA, polypeptide 7, cytochrome P450-HFLA, flavoprotein-linked monooxygenase, microsomal monooxygenase, P-450(HFL33), P-450111A7, P450-HFLA, P450HLp2, xenobiotic monooxygenase
Gene Symbols:
CYP3A7
Isotype:
IgG
Purification Method:
Protein A
Gene:
CYP3A7
Antigen: CYP3A7
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Conjugate: Unconjugated
Host Species: Rabbit
Target Species: Human, Mouse, Rat
Gene Accession No.: P24462
Gene ID (Entrez): 1551
Immunogen: Recombinant Human CYP3A7 protein, Pro344-Asp497 (Accession #P24462)
Primary or Secondary: Primary
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Concentration: 0.5 mg/mL
Classification: Polyclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 50% glycerol and 0.05% Proclin 300, pH 7.4
Gene Alias: aryl hydrocarbon hydroxylase, CP37, CYP3A7, CYPIIIA7, Cytochrome P450 3A7, cytochrome P450 family 3 subfamily A member 7, cytochrome P450, family 3, subfamily A, polypeptide 7, cytochrome P450, subfamily IIIA, polypeptide 7, cytochrome P450-HFLA, flavoprotein-linked monooxygenase, microsomal monooxygenase, P-450(HFL33), P-450111A7, P450-HFLA, P450HLp2, xenobiotic monooxygenase
Gene Symbols: CYP3A7
Isotype: IgG
Purification Method: Protein A
Gene: CYP3A7
Antigen:
CYP3A7
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Conjugate:
Unconjugated
Host Species:
Rabbit
Target Species:
Human, Mouse, Rat
Gene Accession No.:
P24462
Gene ID (Entrez):
1551
Immunogen:
Recombinant Human CYP3A7 protein, Pro344-Asp497 (Accession #P24462)
Primary or Secondary:
Primary
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Concentration:
0.5 mg/mL
Classification:
Polyclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 50% glycerol and 0.05% Proclin 300, pH 7.4
Gene Alias:
aryl hydrocarbon hydroxylase, CP37, CYP3A7, CYPIIIA7, Cytochrome P450 3A7, cytochrome P450 family 3 subfamily A member 7, cytochrome P450, family 3, subfamily A, polypeptide 7, cytochrome P450, subfamily IIIA, polypeptide 7, cytochrome P450-HFLA, flavoprotein-linked monooxygenase, microsomal monooxygenase, P-450(HFL33), P-450111A7, P450-HFLA, P450HLp2, xenobiotic monooxygenase
Gene Symbols:
CYP3A7
Isotype:
IgG
Purification Method:
Protein A
Gene:
CYP3A7
Antigen: G6PD
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Conjugate: Unconjugated
Host Species: Rabbit
Target Species: Mouse, Rat
Gene Accession No.: P05370, Q00612
Gene ID (Entrez): 14381, 24377
Immunogen: Recombinant Rat G6PD protein, Met1-Leu515 (Accession #P05370)
Primary or Secondary: Primary
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Concentration: 0.5 mg/mL
Classification: Polyclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 50% glycerol and 0.05% Proclin 300, pH 7.4
Gene Alias: G28A, G6PD, G6PD1, G6pd-1, G6pdx, Glucose-6-phosphate 1-dehydrogenase, glucose-6-phosphate 1-dehydrogenase X, glucose-6-phosphate dehydrogenase, glucose-6-phosphate dehydrogenase X-linked, Gpdx
Gene Symbols: G6PD, G6pdx
Isotype: IgG
Purification Method: Protein A
Gene: G6pdx
Antigen:
G6PD
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Conjugate:
Unconjugated
Host Species:
Rabbit
Target Species:
Mouse, Rat
Gene Accession No.:
P05370, Q00612
Gene ID (Entrez):
14381, 24377
Immunogen:
Recombinant Rat G6PD protein, Met1-Leu515 (Accession #P05370)
Primary or Secondary:
Primary
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Concentration:
0.5 mg/mL
Classification:
Polyclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 50% glycerol and 0.05% Proclin 300, pH 7.4
Gene Alias:
G28A, G6PD, G6PD1, G6pd-1, G6pdx, Glucose-6-phosphate 1-dehydrogenase, glucose-6-phosphate 1-dehydrogenase X, glucose-6-phosphate dehydrogenase, glucose-6-phosphate dehydrogenase X-linked, Gpdx
Gene Symbols:
G6PD, G6pdx
Isotype:
IgG
Purification Method:
Protein A
Gene:
G6pdx