32-580-0

PTEN Monoclonal Antibody (2F4C9), Invitrogen™

Manufacturer: Invitrogen

Select a Size

Pack Size SKU Availability Price
Each of 1 32-580-0-Each-of-1 In Stock ₹ 36,790.80

32-580-0 - Each of 1

₹ 36,790.80

In Stock

Quantity

1

Base Price: ₹ 36,790.80

GST (18%): ₹ 6,622.344

Total Price: ₹ 43,413.144

Antigen

PTEN

Classification

Monoclonal

Concentration

0.5 mg/mL

Formulation

PBS with 0.1% sodium azide; pH 7.4

Gene Accession No.

O08586, P60484

Gene Symbols

PTEN

Immunogen

Recombinant protein derived from the PTEN protein.

Quantity

100 μg

Primary or Secondary

Primary

Target Species

Human, Mouse

Product Type

Antibody

Isotype

IgG2a

Applications

ELISA, Immunocytochemistry, Western Blot

Clone

2F4C9

Conjugate

Unconjugated

Gene

PTEN

Gene Alias

10q23del; 2310035O07Rik; A130070J02Rik; AI463227; B430203M17Rik; BZS; CWS1; DEC; GLM2; homolog of human mutated in multiple advanced cancers; MHAM; mitochondrial phosphatase and tensin protein alpha; mitochondrial PTENalpha; Mmac; MMAC1; MMAC1 phosphatase and tensin homolog deleted on chromosome 10; mutated in multiple advanced cancers 1; Phosphatase and tensin homolog; phosphatase and tensin homolog (mutated in multiple advanced cancers 1); phosphatase and tensin homolog deleted on chromosome ten; phosphatase and tensin-like protein; phosphatidylinositol 3; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; phosphatidylinositol-3; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; protein tyrosine phosphatase and tensin-like protein; PTEN; pten tumor suppressor; PTEN1; TEP1

Host Species

Mouse

Purification Method

Protein A

Regulatory Status

RUO

Gene ID (Entrez)

19211, 5728

Content And Storage

-20°C

Form

Liquid

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Description

  • 32-5800 reacts specifically with the human PTEN protein
  • Reactivity was confirmed with cell lines which contain endogenous PTEN (NIH3T3, K652, and DU145 prostate cancer line) as well as transfected cell lines (Rat1 and 293T cells)
  • This antibody detects the ∽55 kDa PTEN protein and was successfully used in western blotting analysis of PTEN in breast cancer cell lines
  • No cross-reactivity to any other proteins has been detected
  • PTEN was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency
  • The PTEN gene is a phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase
  • It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases
  • Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates
  • PTEN negatively regulates intracellular levels of phosphatidylinositol-3, 4, 5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway
  • PTEN plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation
  • Also, PTEN may be a negative regulator of insulin signaling and glucose metabolism in adipose tissue
  • The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form of PTEN induces less tumor suppressive ability.

Compare Similar Items

Show Difference

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Invitrogen

32-580-0

--


Antigen:
PTEN

Classification:
Monoclonal

Concentration:
0.5 mg/mL

Formulation:
PBS with 0.1% sodium azide; pH 7.4

Gene Accession No.:
O08586, P60484

Gene Symbols:
PTEN

Immunogen:
Recombinant protein derived from the PTEN protein.

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Human, Mouse

Product Type:
Antibody

Isotype:
IgG2a

Applications:
ELISA, Immunocytochemistry, Western Blot

Clone:
2F4C9

Conjugate:
Unconjugated

Gene:
PTEN

Gene Alias:
10q23del; 2310035O07Rik; A130070J02Rik; AI463227; B430203M17Rik; BZS; CWS1; DEC; GLM2; homolog of human mutated in multiple advanced cancers; MHAM; mitochondrial phosphatase and tensin protein alpha; mitochondrial PTENalpha; Mmac; MMAC1; MMAC1 phosphatase and tensin homolog deleted on chromosome 10; mutated in multiple advanced cancers 1; Phosphatase and tensin homolog; phosphatase and tensin homolog (mutated in multiple advanced cancers 1); phosphatase and tensin homolog deleted on chromosome ten; phosphatase and tensin-like protein; phosphatidylinositol 3; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; phosphatidylinositol-3; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; protein tyrosine phosphatase and tensin-like protein; PTEN; pten tumor suppressor; PTEN1; TEP1

Host Species:
Mouse

Purification Method:
Protein A

Regulatory Status:
RUO

Gene ID (Entrez):
19211, 5728

Content And Storage:
-20°C

Form:
Liquid

Img

Invitrogen

32-600-0

--


Antigen:
Desmoglein 1

Classification:
Monoclonal

Concentration:
0.5 mg/mL

Formulation:
PBS with 0.1% sodium azide; pH 7.4

Gene Accession No.:
Q02413

Gene Symbols:
DSG1

Immunogen:
Human desmoglein-1 intracellular domain.

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG1

Applications:
Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot

Clone:
27B2

Conjugate:
Unconjugated

Gene:
DSG1

Gene Alias:
Cadherin family member 4; CDHF4; desmoglein 1; desmoglein 1 beta; desmoglein 1 gamma; desmoglein-1; Desmosomal glycoprotein 1; DG1; DSG; DSG1; Dsg1b; Dsg1c; EPKHE; EPKHIA; Pemphigus foliaceus antigen; PPKS1; SPPK1

Host Species:
Mouse

Purification Method:
Protein A

Regulatory Status:
RUO

Gene ID (Entrez):
1828

Content And Storage:
-20°C

Form:
Liquid

Img

Fischer Scientific

32-600-10

--


Antigen:
__

Classification:
__

Concentration:
__

Formulation:
__

Gene Accession No.:
__

Gene Symbols:
__

Immunogen:
__

Quantity:
300 μg

Primary or Secondary:
__

Target Species:
__

Product Type:
Rapid DyLight 650 Antibody Labeling Kit

Isotype:
__

Applications:
__

Clone:
__

Conjugate:
DyLight 650

Gene:
__

Gene Alias:
__

Host Species:
__

Purification Method:
__

Regulatory Status:
__

Gene ID (Entrez):
__

Content And Storage:
Store at -20°C. Avoid freeze-thaw cycles.

Form:
__

Img

Fischer Scientific

32-600-15

--


Antigen:
__

Classification:
__

Concentration:
__

Formulation:
__

Gene Accession No.:
__

Gene Symbols:
__

Immunogen:
__

Quantity:
1 mg

Primary or Secondary:
__

Target Species:
__

Product Type:
Rapid DyLight 650 Antibody Labeling Kit

Isotype:
__

Applications:
__

Clone:
__

Conjugate:
DyLight 650

Gene:
__

Gene Alias:
__

Host Species:
__

Purification Method:
__

Regulatory Status:
__

Gene ID (Entrez):
__

Content And Storage:
Store at -20°C. Avoid freeze-thaw cycles.

Form:
__