Claudin 14 Polyclonal Antibody, Invitrogen™

Description

• Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space
• These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet
• The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands
• The encoded protein also binds specifically to the WW domain of Yes-associated protein
• Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness
• Several transcript variants encoding the same protein have been found for this gene.