3851949

Bcl-X Mouse, Unlabeled, Clone: 44, BD

Mouse Monoclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

Bcl-X

Concentration

250μg/mL

Classification

Monoclonal

Host Species

Mouse

Research Discipline

Cell Biology

Formulation

Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

Isotype

IgG1

Purification Method

Affinity Purified

Clone

44

Applications

Western Blot

Conjugate

Unconjugated

Regulatory Status

RUO

Target Species

Human, Mouse, Rat

Immunogen

Human Bcl-Xl aa. 18-233

Primary or Secondary

Primary

Content And Storage

Store undiluted at -20°C.

Description

  • Bcl-x is related to the Bcl-2 protein and can function independently of Bcl-2 in regulating apoptosis (programmed cell death)
  • The bcl-x transcript is expressed in a number of tissues, with the highest levels in the lymphoid and central nervous systems
  • Two distinct cDNA species, bcl-xL and bcl-xS, have been observed and appear to arise from alternate 5' splice sites located within the first coding exon of the bcl-x gene
  • Bcl-xL is composed of 233 amino acids and is similar in size and structure to Bcl-2
  • The Bcl-xS polypeptide shows a deletion of 63 amino acids which consist of the region of Bcl-xL with the highest degree of amino acid identity to Bcl-2
  • Like Bcl-2, Bcl-xL inhibits cell death upon growth factor withdrawal when transfected into an IL-3-dependent cell line
  • However, Bcl-xS inhibits Bcl-2 mediated cell survival.

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Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

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