3855758

NMDAR2B Mouse, Unlabeled, Clone: 13, BD

Mouse Monoclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

NMDAR2B

Concentration

250μg/mL

Classification

Monoclonal

Host Species

Mouse

Research Discipline

Cell Biology

Formulation

Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

Isotype

IgG2b

Purification Method

Affinity Purified

Description

N-Methyl-D-Aspartate Receptor 2B

Clone

13

Applications

Western Blot

Conjugate

Unconjugated

Regulatory Status

RUO

Target Species

Human, Mouse, Rat

Immunogen

Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

Primary or Secondary

Primary

Content And Storage

Store undiluted at -20°C.

Description

  • The majority of synapses in the central nervous system utilize glutamate as a neurotransmitter to produce rapid neuronal excitation
  • Glutamate has a diverse array of receptors that can be categorized into two groups: ionotropic and metabotropic
  • The ionotropic receptors are subdivided into two distint types: 1) receptors for N-methyl D-aspartate (NMDAR) and 2) non-NMDA receptors for AMPA and kainate
  • Three types of NMDAR2 have been identified: NR2A, NR2B, and NR2C
  • NR2A and NR2B contain a C-terminal extension (>600 amino acids) that has small scattered regions of conserved sequence
  • The three NR2 mRNAs show overlapping, differential expression patterns in the rat brain
  • NR2B has been reported to be expressed in the forebrain, thalamic nuclei, amygdaloid nuclei, caudateputamen, and in restricted regions of the olfactory bulb
  • Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

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Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

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Clone:
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Conjugate:
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RUO

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