3855840

p130 [Cas] Mouse, Unlabeled, Clone: 21, BD

Mouse Monoclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

p130 [Cas]

Concentration

250μg/mL

Classification

Monoclonal

Host Species

Mouse

Research Discipline

Cell Biology

Formulation

Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

Isotype

IgG1

Purification Method

Affinity Purified

Clone

21

Applications

Western Blot

Conjugate

Unconjugated

Regulatory Status

RUO

Target Species

Canine, Chicken, Human, Mouse, Rat

Immunogen

Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

Primary or Secondary

Primary

Content And Storage

Store undiluted at -20°C.

Description

  • Description p47 [v-crk] is the product of a transforming gene, v- crk , that was isolated from avian sarcoma viruses
  • The v-crk protein is a fusion product of the viral gag protein and a part of cellular crk that includes SH2 and SH3 domains
  • v-crk induced transformation increases tyrosine phosphorylation of several cellular proteins, including p130 [Cas]
  • p130 [Cas] is tightly associated with v-crk via the SH2 domain of v-crk
  • Tyrosine phosphorylation of p130 [Cas] occurs in conjunction with cellular transformation in cells that express v-src or v-crk
  • This phosphorylation leads to a change in p130 [Cas] localization from the cytoplasm to the cell membrane and, possibly, to the nucleus
  • Since p130 [Cas] also associates with v-src, it may be a v-src substrate.

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Antigen:
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Concentration:
250μg/mL

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Mouse

Research Discipline:
Cell Biology

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Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

Isotype:
IgG1

Purification Method:
Affinity Purified

Clone:
21

Applications:
Western Blot

Conjugate:
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Target Species:
Canine, Chicken, Human, Mouse, Rat

Immunogen:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

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Primary

Content And Storage:
Store undiluted at -20°C.

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