3967715

Oct3/4 Mouse, Unlabeled, Clone: 40/OCT-3, BD

Mouse Monoclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

OCT3/4

Concentration

250μg/mL

Classification

Monoclonal

Host Species

Mouse

Research Discipline

Cell Biology

Formulation

Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

Isotype

IgG1 κ

Purification Method

Affinity Purified

Description

Oct3, OTF3, Oct4, OTF4, POU5F1

Clone

40/OCT-3

Applications

In vitro Assay, Western Blot

Conjugate

Unconjugated

Regulatory Status

RUO

Target Species

Human, Mouse

Immunogen

Mouse Oct3 aa. 252-372 Recombinant Protein

Primary or Secondary

Primary

Content And Storage

Store undiluted at -20°C.

Description

  • Development of a multicellular organism from a single fertilized cell is regulated by the coordinated activity of DNA transcription factors
  • Oct3/4, a member of the POU family of transcription factors, functions in pluripotent cells of early embryonic stem cell (ES) lines and embryonal carcinomas (EC)
  • Other members of the POU family include Oct1, Oct2, Pit-1, and unc-86
  • The POU domain, a 150-amino acid region that determines binding specificity, is conserved among these proteins and consists of 3 subdomains: POU-specific A and B subdomains and a homeobox-like subdomain
  • Oct3/4 is expressed in undifferentiated cells, but is lost as cells are induced to differentiate
  • Oct3/4 is not expressed in adult tissues
  • The interaction of Oct3/4 with SOX2, another embryonic transcription factor, produces an active complex that regulates expression of genes such as Nanog, UTF1, and FGF4
  • Although Oct3/4 is specifically phosphorylated on serine residues, this modification is not required for DNA binding, but may affect its transactivation potential
  • Thus, Oct3/4 is a transcription factor that plays an important role in determining early steps of embryogenesis and differentiation
  • Host Species: Mouse Clone: 40 Isotype: IgG1 κ Species Reactivity: Human Immunogen: Mouse Oct3 aa
  • 252-372 Recombinant Protein Formula Weight [Chemical]: 46kDa Western Blotting

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3967715

Mouse Monoclonal Antibody...


Antigen:
OCT3/4

Concentration:
250μg/mL

Classification:
Monoclonal

Host Species:
Mouse

Research Discipline:
Cell Biology

Formulation:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

Isotype:
IgG1 κ

Purification Method:
Affinity Purified

Description:
Oct3, OTF3, Oct4, OTF4, POU5F1

Clone:
40/OCT-3

Applications:
In vitro Assay, Western Blot

Conjugate:
Unconjugated

Regulatory Status:
RUO

Target Species:
Human, Mouse

Immunogen:
Mouse Oct3 aa. 252-372 Recombinant Protein

Primary or Secondary:
Primary

Content And Storage:
Store undiluted at -20°C.

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Host Species:
Mouse

Research Discipline:
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Isotype:
IgG1 κ

Purification Method:
Affinity Purified

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Classification:
__

Host Species:
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Research Discipline:
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Isotype:
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Purification Method:
__

Description:
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Clone:
__

Applications:
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Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.

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