3968377

ALDH Mouse anti-Human, Unlabeled, Clone: 44, BD

Mouse Monoclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

ALDH

Concentration

250μg/mL

Classification

Monoclonal

Host Species

Mouse

Research Discipline

Cell Biology

Formulation

Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

Isotype

IgG1

Purification Method

Affinity Purified

Clone

44

Applications

Western Blot

Conjugate

Unconjugated

Regulatory Status

RUO

Target Species

Human

Immunogen

Human ALDH1 aa. 7-128

Primary or Secondary

Primary

Content And Storage

Store undiluted at -20°C.

Description

  • Aldehyde dehydrogenase (ALDH) is a ubiquitous enzyme located in nearly all mammalian tissues
  • It catalyzes the irreversible oxidation of a range of aliphatic and aromatic aldehydes to their corresponding carboxylic acids
  • There are multiple isoforms of ALDH which are subdivided into three classes
  • Class I includes the cytosolic isoforms
  • Class II includes the mitochondrial isoforms
  • Class III includes the microsomal, cytosolic tumor specific, and cytosolic dioxin-inducible forms
  • At least twelve human ALDH isoforms have been identified
  • Mutations of many of these proteins such as ALDH1, ALDH2, ALDH4, and ALDH10 have been implicated in multiple human metabolic disorders and clinical abnormalities
  • At the amino acid level, human ALDH isoforms exhibit a wide range of diversity (15% to about 80%)
  • However, multiple protein regions have been highly conserved and are important for functional activities
  • A well-characterized member of the human ALDH family is ALDH1
  • It plays a major role in the biosynthesis of retinoic acid from retinol (vitamin A)
  • Retinoic acid, the biologically active form of retinol, is a regulator of cellular proliferation, differentiation, and survival
  • Host Species: Mouse Clone: 44 Isotype: IgG1 Species Reactivity: Human Immunogen: Human ALDH1 aa
  • 7-128 Formula Weight [Chemical]: 55kDa Immunofluorescence, Western Blotting

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Antigen:
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Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

Isotype:
IgG1

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Affinity Purified

Clone:
44

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Western Blot

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Unconjugated

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Concentration:
250μg/mL

Classification:
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Host Species:
Mouse

Research Discipline:
Cell Biology

Formulation:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

Isotype:
IgG1

Purification Method:
Affinity Purified

Clone:
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Applications:
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Conjugate:
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Target Species:
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