CD80 Mouse anti-Human, V450, Clone: L307.4, BD

Description

• Reacts with B7/BB1, a 60kDa transmembrane glycoprotein which was clustered as CD80 in the Fifth International Workshop on Human Leukocyte Differentiation Antigens
• CD80, a member of the Ig supergene family, is expressed on activated B cells, macrophages, and dendritic cells
• It is the ligand for two molecules expressed on T cells, CD28 and CD152 (CTLA-4)
• CD80 is also expressed on activated CD4+ and CD8+ T cells, appearing late after activation suggesting that activated T cells may be capable of autocrine costimulation via the CD28 activation pathway
• The binding of CD28 by anti-CD28 or by CD80 results in T-cell activation and a signal for IL-2 production
• The antibody is conjugated to BD Horizon™ V450, which has been developed for use in multicolor flow cytometry experiments and is available exclusively from BD Biosciences
• It is excited by the Violet laser Ex max of 406nm and has an Em Max at 450nm
• Conjugates with BD Horizon™ V450 can be used in place of Pacific Blue™ conjugates
• Host Species: Mouse Clone: L307.4 Isotype: IgG1 κ Species Reactivity: Human Flow Cytometry