40-411-7180
CD117 (c-Kit) Monoclonal Antibody (2B8), Brilliant Violet™ 421, eBioscience™, Invitrogen™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 40-411-7180-Each-of-1 | In Stock | ₹ 12,748.44 |
40-411-7180 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 12,748.44
GST (18%): ₹ 2,294.719
Total Price: ₹ 15,043.159
Antigen
CD117 (c-Kit)
Classification
Monoclonal
Concentration
0.2 mg/mL
Formulation
PBS with BSA and 0.09% sodium azide, pH 7.2
Gene Accession No.
P05532, Q2HWD6
Gene Symbols
KIT
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
16590, 396810
Content And Storage
4°, C, store in dark, DO NOT FREEZE!
Isotype
IgG2b κ
Applications
Flow Cytometry
Clone
2B8
Conjugate
Brilliant Violet 421
Gene
KIT
Gene Alias
belly-spot, Bs, CD117, ckit, C-Kit, c-KIT gene1, c-kit protein, c-kit proto-oncogene protein, c-kit receptor, c-kit receptor tyrosine kinase, dominant spotting, Dominant white spotting, Fdc, Gsfsco1, Gsfsco5, Gsfsow3, KIT, kit oncogene, KIT proto-oncogene receptor tyrosine kinase, KIT proto-oncogene, receptor tyrosine kinase, mast cell growth factor receptor, mast/stem cell growth factor receptor, mast/stem cell growth factor receptor Kit, MGF, p145 c-kit, PBT, Piebald trait protein, protein kinase, proto-oncogene c-Kit, proto-oncogene tyrosine-protein kinase Kit, receptor tyrosine kinase c-kit, receptor tyrosine kinase type III, SCFR, SCO1, SCO5, Sl, soluble KIT variant 1, SOW3, spotted sterile male, Ssm, Steel Factor Receptor, Tr-kit, tyrosine kinase receptor, tyrosine kinase receptor c-KIT, tyrosine-protein kinase Kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein, W
Host Species
Rat
Quantity
25 μg
Primary or Secondary
Primary
Target Species
Mouse, Porcine
Form
Liquid
Related Products
Description
- KIT (c-KIT) is a proto-oncogene and a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor)
- KIT was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit
- KIT together with its ligand regulates growth and activation of a variety of hemopoietic and non-hemopoietic cells
- Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism
- Recently, deregulation of the KIT receptor TK by the prevalent activation loop mutation D816V has served as a focal point in therapeutic strategies aimed at curbing neoplastic mast cell growth
- c-Kit is expressed in hematopoietic stem cells, germ cells, mast cells and gastrointestinal tract cajal cells
- Upon binding of its ligand stem cell factor (SCF), c-kit dimerizes, resulting in receptor activation and autophosphorylation of various tyrosine residues including tyrosine 703 located on the cytoplasmic domain of the receptor
- This modification allows docking of Grb2 and activation of the Ras/ERK signaling pathway
- SCF/c-kit can activate multiple downstream signaling pathways including PI3K, PLC-gamma and JAK/STAT
- c-kit receptor activation is essential for hematopoiesis, stem cell maintenance and gametogenesis.
Compare Similar Items
Show Difference
Antigen: CD117 (c-Kit)
Classification: Monoclonal
Concentration: 0.2 mg/mL
Formulation: PBS with BSA and 0.09% sodium azide, pH 7.2
Gene Accession No.: P05532, Q2HWD6
Gene Symbols: KIT
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 16590, 396810
Content And Storage: 4°, C, store in dark, DO NOT FREEZE!
Isotype: IgG2b κ
Applications: Flow Cytometry
Clone: 2B8
Conjugate: Brilliant Violet 421
Gene: KIT
Gene Alias: belly-spot, Bs, CD117, ckit, C-Kit, c-KIT gene1, c-kit protein, c-kit proto-oncogene protein, c-kit receptor, c-kit receptor tyrosine kinase, dominant spotting, Dominant white spotting, Fdc, Gsfsco1, Gsfsco5, Gsfsow3, KIT, kit oncogene, KIT proto-oncogene receptor tyrosine kinase, KIT proto-oncogene, receptor tyrosine kinase, mast cell growth factor receptor, mast/stem cell growth factor receptor, mast/stem cell growth factor receptor Kit, MGF, p145 c-kit, PBT, Piebald trait protein, protein kinase, proto-oncogene c-Kit, proto-oncogene tyrosine-protein kinase Kit, receptor tyrosine kinase c-kit, receptor tyrosine kinase type III, SCFR, SCO1, SCO5, Sl, soluble KIT variant 1, SOW3, spotted sterile male, Ssm, Steel Factor Receptor, Tr-kit, tyrosine kinase receptor, tyrosine kinase receptor c-KIT, tyrosine-protein kinase Kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein, W
Host Species: Rat
Quantity: 25 μg
Primary or Secondary: Primary
Target Species: Mouse, Porcine
Form: Liquid
Antigen:
CD117 (c-Kit)
Classification:
Monoclonal
Concentration:
0.2 mg/mL
Formulation:
PBS with BSA and 0.09% sodium azide, pH 7.2
Gene Accession No.:
P05532, Q2HWD6
Gene Symbols:
KIT
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
16590, 396810
Content And Storage:
4°, C, store in dark, DO NOT FREEZE!
Isotype:
IgG2b κ
Applications:
Flow Cytometry
Clone:
2B8
Conjugate:
Brilliant Violet 421
Gene:
KIT
Gene Alias:
belly-spot, Bs, CD117, ckit, C-Kit, c-KIT gene1, c-kit protein, c-kit proto-oncogene protein, c-kit receptor, c-kit receptor tyrosine kinase, dominant spotting, Dominant white spotting, Fdc, Gsfsco1, Gsfsco5, Gsfsow3, KIT, kit oncogene, KIT proto-oncogene receptor tyrosine kinase, KIT proto-oncogene, receptor tyrosine kinase, mast cell growth factor receptor, mast/stem cell growth factor receptor, mast/stem cell growth factor receptor Kit, MGF, p145 c-kit, PBT, Piebald trait protein, protein kinase, proto-oncogene c-Kit, proto-oncogene tyrosine-protein kinase Kit, receptor tyrosine kinase c-kit, receptor tyrosine kinase type III, SCFR, SCO1, SCO5, Sl, soluble KIT variant 1, SOW3, spotted sterile male, Ssm, Steel Factor Receptor, Tr-kit, tyrosine kinase receptor, tyrosine kinase receptor c-KIT, tyrosine-protein kinase Kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein, W
Host Species:
Rat
Quantity:
25 μg
Primary or Secondary:
Primary
Target Species:
Mouse, Porcine
Form:
Liquid
Antigen: CD117 (c-Kit)
Classification: Monoclonal
Concentration: 0.2 mg/mL
Formulation: PBS with BSA and 0.09% sodium azide, pH 7.2
Gene Accession No.: P05532, Q2HWD6
Gene Symbols: KIT
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 16590, 396810
Content And Storage: 4°, C, store in dark, DO NOT FREEZE!
Isotype: IgG2b κ
Applications: Flow Cytometry
Clone: 2B8
Conjugate: Brilliant Violet 421
Gene: KIT
Gene Alias: belly-spot, Bs, CD117, ckit, C-Kit, c-KIT gene1, c-kit protein, c-kit proto-oncogene protein, c-kit receptor, c-kit receptor tyrosine kinase, dominant spotting, Dominant white spotting, Fdc, Gsfsco1, Gsfsco5, Gsfsow3, KIT, kit oncogene, KIT proto-oncogene receptor tyrosine kinase, KIT proto-oncogene, receptor tyrosine kinase, mast cell growth factor receptor, mast/stem cell growth factor receptor, mast/stem cell growth factor receptor Kit, MGF, p145 c-kit, PBT, Piebald trait protein, protein kinase, proto-oncogene c-Kit, proto-oncogene tyrosine-protein kinase Kit, receptor tyrosine kinase c-kit, receptor tyrosine kinase type III, SCFR, SCO1, SCO5, Sl, soluble KIT variant 1, SOW3, spotted sterile male, Ssm, Steel Factor Receptor, Tr-kit, tyrosine kinase receptor, tyrosine kinase receptor c-KIT, tyrosine-protein kinase Kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein, W
Host Species: Rat
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Mouse, Porcine
Form: Liquid
Antigen:
CD117 (c-Kit)
Classification:
Monoclonal
Concentration:
0.2 mg/mL
Formulation:
PBS with BSA and 0.09% sodium azide, pH 7.2
Gene Accession No.:
P05532, Q2HWD6
Gene Symbols:
KIT
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
16590, 396810
Content And Storage:
4°, C, store in dark, DO NOT FREEZE!
Isotype:
IgG2b κ
Applications:
Flow Cytometry
Clone:
2B8
Conjugate:
Brilliant Violet 421
Gene:
KIT
Gene Alias:
belly-spot, Bs, CD117, ckit, C-Kit, c-KIT gene1, c-kit protein, c-kit proto-oncogene protein, c-kit receptor, c-kit receptor tyrosine kinase, dominant spotting, Dominant white spotting, Fdc, Gsfsco1, Gsfsco5, Gsfsow3, KIT, kit oncogene, KIT proto-oncogene receptor tyrosine kinase, KIT proto-oncogene, receptor tyrosine kinase, mast cell growth factor receptor, mast/stem cell growth factor receptor, mast/stem cell growth factor receptor Kit, MGF, p145 c-kit, PBT, Piebald trait protein, protein kinase, proto-oncogene c-Kit, proto-oncogene tyrosine-protein kinase Kit, receptor tyrosine kinase c-kit, receptor tyrosine kinase type III, SCFR, SCO1, SCO5, Sl, soluble KIT variant 1, SOW3, spotted sterile male, Ssm, Steel Factor Receptor, Tr-kit, tyrosine kinase receptor, tyrosine kinase receptor c-KIT, tyrosine-protein kinase Kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein, W
Host Species:
Rat
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Mouse, Porcine
Form:
Liquid
Antigen: CD127
Classification: Monoclonal
Concentration: 0.2 mg/mL
Formulation: PBS with BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.: P16872
Gene Symbols: Il7r
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 16197
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Isotype: IgG2a κ
Applications: Flow Cytometry
Clone: A7R34
Conjugate: Brilliant Violet 421
Gene: Il7r
Gene Alias: CD127; CD127 antigen; CDW127; IL 7 receptor; IL 7R a; IL 7R subunit alpha; IL 7R a; IL 7Ra; IL 7Ra; IL7 receptor; IL-7 receptor alpha chain; IL7 receptor subunit alpha; IL-7 receptor subunit alpha; IL7R; IL-7R; IL7R a; IL7R alpha; IL7R subunit alpha; IL-7R subunit alpha; IL7R a; IL7RA; IL-7RA; IL-7Ralpha; IL-7R-alpha; IL7Ra; ILRA; interleukin 7 receptor; interleukin 7 receptor alpha chain; interleukin 7 receptor isoform H5-6; Interleukin7 receptor subunit alpha; interleukin-7 receptor subunit alpha; MGC107557; sCD127; soluble IL 7 receptor; soluble IL 7R
Host Species: Rat
Quantity: 25 μg
Primary or Secondary: Primary
Target Species: Mouse
Form: Liquid
Antigen:
CD127
Classification:
Monoclonal
Concentration:
0.2 mg/mL
Formulation:
PBS with BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.:
P16872
Gene Symbols:
Il7r
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
16197
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Isotype:
IgG2a κ
Applications:
Flow Cytometry
Clone:
A7R34
Conjugate:
Brilliant Violet 421
Gene:
Il7r
Gene Alias:
CD127; CD127 antigen; CDW127; IL 7 receptor; IL 7R a; IL 7R subunit alpha; IL 7R a; IL 7Ra; IL 7Ra; IL7 receptor; IL-7 receptor alpha chain; IL7 receptor subunit alpha; IL-7 receptor subunit alpha; IL7R; IL-7R; IL7R a; IL7R alpha; IL7R subunit alpha; IL-7R subunit alpha; IL7R a; IL7RA; IL-7RA; IL-7Ralpha; IL-7R-alpha; IL7Ra; ILRA; interleukin 7 receptor; interleukin 7 receptor alpha chain; interleukin 7 receptor isoform H5-6; Interleukin7 receptor subunit alpha; interleukin-7 receptor subunit alpha; MGC107557; sCD127; soluble IL 7 receptor; soluble IL 7R
Host Species:
Rat
Quantity:
25 μg
Primary or Secondary:
Primary
Target Species:
Mouse
Form:
Liquid
Antigen: CD127
Classification: Monoclonal
Concentration: 0.2 mg/mL
Formulation: PBS with BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.: P16872
Gene Symbols: Il7r
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 16197
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Isotype: IgG2a κ
Applications: Flow Cytometry
Clone: A7R34
Conjugate: Brilliant Violet 421
Gene: Il7r
Gene Alias: CD127; CD127 antigen; CDW127; IL 7 receptor; IL 7R a; IL 7R subunit alpha; IL 7R a; IL 7Ra; IL 7Ra; IL7 receptor; IL-7 receptor alpha chain; IL7 receptor subunit alpha; IL-7 receptor subunit alpha; IL7R; IL-7R; IL7R a; IL7R alpha; IL7R subunit alpha; IL-7R subunit alpha; IL7R a; IL7RA; IL-7RA; IL-7Ralpha; IL-7R-alpha; IL7Ra; ILRA; interleukin 7 receptor; interleukin 7 receptor alpha chain; interleukin 7 receptor isoform H5-6; Interleukin7 receptor subunit alpha; interleukin-7 receptor subunit alpha; MGC107557; sCD127; soluble IL 7 receptor; soluble IL 7R
Host Species: Rat
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Mouse
Form: Liquid
Antigen:
CD127
Classification:
Monoclonal
Concentration:
0.2 mg/mL
Formulation:
PBS with BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.:
P16872
Gene Symbols:
Il7r
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
16197
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Isotype:
IgG2a κ
Applications:
Flow Cytometry
Clone:
A7R34
Conjugate:
Brilliant Violet 421
Gene:
Il7r
Gene Alias:
CD127; CD127 antigen; CDW127; IL 7 receptor; IL 7R a; IL 7R subunit alpha; IL 7R a; IL 7Ra; IL 7Ra; IL7 receptor; IL-7 receptor alpha chain; IL7 receptor subunit alpha; IL-7 receptor subunit alpha; IL7R; IL-7R; IL7R a; IL7R alpha; IL7R subunit alpha; IL-7R subunit alpha; IL7R a; IL7RA; IL-7RA; IL-7Ralpha; IL-7R-alpha; IL7Ra; ILRA; interleukin 7 receptor; interleukin 7 receptor alpha chain; interleukin 7 receptor isoform H5-6; Interleukin7 receptor subunit alpha; interleukin-7 receptor subunit alpha; MGC107557; sCD127; soluble IL 7 receptor; soluble IL 7R
Host Species:
Rat
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Mouse
Form:
Liquid