46-117-282
CD117 (c-Kit) Monoclonal Antibody (ACK2), PerCP-eFluor™ 710, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 46-117-282-Each-of-1 | In Stock | ₹ 31,229.40 |
46-117-282 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 31,229.40
GST (18%): ₹ 5,621.292
Total Price: ₹ 36,850.692
Antigen
CD117 (c-Kit)
Classification
Monoclonal
Concentration
0.2 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
P05532
Gene Symbols
KIT
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
16590
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
ACK2
Conjugate
PerCP-eFluor 710
Gene
KIT
Gene Alias
belly-spot; Bs; CD117; ckit; C-Kit; c-KIT gene1; c-kit protein; c-kit proto-oncogene protein; c-kit receptor; c-kit receptor tyrosine kinase; dominant spotting; Dominant white spotting; Fdc; Gsfsco1; Gsfsco5; Gsfsow3; KIT; kit oncogene; KIT proto-oncogene receptor tyrosine kinase; KIT proto-oncogene, receptor tyrosine kinase; mast cell growth factor receptor; mast/stem cell growth factor receptor; mast/stem cell growth factor receptor Kit; MGF; p145 c-kit; PBT; Piebald trait protein; protein kinase; proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; receptor tyrosine kinase c-kit; receptor tyrosine kinase type III; SCFR; SCO1; SCO5; Sl; soluble KIT variant 1; SOW3; spotted sterile male; Ssm; Steel Factor Receptor; Tr-kit; tyrosine kinase receptor; tyrosine kinase receptor c-KIT; tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein; W
Host Species
Rat
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG2b κ
Related Products
Description
- The ACK2 MAb reacts with mouse CD117, also known as c-Kit receptor, Steel factor receptor and stem cell factor receptor
- A member of the tyrosine kinase receptor family, this 145 kDa molecule is expressed by a majority of hematopoietic progenitor cells characterized in the mouse bone marrow as a small subset of cells positive for Sca-1 and Thy1 (Thy1^lo) and negative for lineage markers
- The interaction of the mouse c-kit receptor and steel factor promotes the proliferation and differentiation of hematopoietic progenitor cells
- CD117 is also expressed by mast cells and plays a role in signaling and activation of these cells
- ACK2 has been reported to be a blocking antibody
- KIT (c-KIT) is a proto-oncogene and a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor)
- KIT was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit
- KIT together with its ligand regulates growth and activation of a variety of hemopoietic and non-hemopoietic cells
- Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism
- Recently, deregulation of the KIT receptor TK by the prevalent activation loop mutation D816V has served as a focal point in therapeutic strategies aimed at curbing neoplastic mast cell growth
- c-Kit is expressed in hematopoietic stem cells, germ cells, mast cells and gastrointestinal tract cajal cells
- Upon binding of its ligand stem cell factor (SCF), c-kit dimerizes, resulting in receptor activation and autophosphorylation of various tyrosine residues including tyrosine 703 located on the cytoplasmic domain of the receptor
- This modification allows docking of Grb2 and activation of the Ras/ERK signaling pathway
- SCF/c-kit can activate multiple downstream signaling pathways including PI3K, PLC-gamma and JAK/STAT
- c-kit receptor activation is essential for hematopoiesis, stem cell maintenance and gametogenesis.
Compare Similar Items
Show Difference
Antigen: CD117 (c-Kit)
Classification: Monoclonal
Concentration: 0.2 mg/mL
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.: P05532
Gene Symbols: KIT
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 16590
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Form: Liquid
Applications: Flow Cytometry
Clone: ACK2
Conjugate: PerCP-eFluor 710
Gene: KIT
Gene Alias: belly-spot; Bs; CD117; ckit; C-Kit; c-KIT gene1; c-kit protein; c-kit proto-oncogene protein; c-kit receptor; c-kit receptor tyrosine kinase; dominant spotting; Dominant white spotting; Fdc; Gsfsco1; Gsfsco5; Gsfsow3; KIT; kit oncogene; KIT proto-oncogene receptor tyrosine kinase; KIT proto-oncogene, receptor tyrosine kinase; mast cell growth factor receptor; mast/stem cell growth factor receptor; mast/stem cell growth factor receptor Kit; MGF; p145 c-kit; PBT; Piebald trait protein; protein kinase; proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; receptor tyrosine kinase c-kit; receptor tyrosine kinase type III; SCFR; SCO1; SCO5; Sl; soluble KIT variant 1; SOW3; spotted sterile male; Ssm; Steel Factor Receptor; Tr-kit; tyrosine kinase receptor; tyrosine kinase receptor c-KIT; tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein; W
Host Species: Rat
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Mouse
Product Type: Antibody
Isotype: IgG2b κ
Antigen:
CD117 (c-Kit)
Classification:
Monoclonal
Concentration:
0.2 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
P05532
Gene Symbols:
KIT
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
16590
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Form:
Liquid
Applications:
Flow Cytometry
Clone:
ACK2
Conjugate:
PerCP-eFluor 710
Gene:
KIT
Gene Alias:
belly-spot; Bs; CD117; ckit; C-Kit; c-KIT gene1; c-kit protein; c-kit proto-oncogene protein; c-kit receptor; c-kit receptor tyrosine kinase; dominant spotting; Dominant white spotting; Fdc; Gsfsco1; Gsfsco5; Gsfsow3; KIT; kit oncogene; KIT proto-oncogene receptor tyrosine kinase; KIT proto-oncogene, receptor tyrosine kinase; mast cell growth factor receptor; mast/stem cell growth factor receptor; mast/stem cell growth factor receptor Kit; MGF; p145 c-kit; PBT; Piebald trait protein; protein kinase; proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; receptor tyrosine kinase c-kit; receptor tyrosine kinase type III; SCFR; SCO1; SCO5; Sl; soluble KIT variant 1; SOW3; spotted sterile male; Ssm; Steel Factor Receptor; Tr-kit; tyrosine kinase receptor; tyrosine kinase receptor c-KIT; tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein; W
Host Species:
Rat
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Mouse
Product Type:
Antibody
Isotype:
IgG2b κ
Antigen: CD127
Classification: Monoclonal
Concentration: 0.2 mg/mL
Formulation: PBS with 0.09% sodium azide, pH 7.2
Gene Accession No.: P16872
Gene Symbols: Il7r
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 16197
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Form: Liquid
Applications: Flow Cytometry
Clone: A7R34
Conjugate: PerCP-eFluor 710
Gene: Il7r
Gene Alias: CD127, CD127 antigen, CDW127, IL 7 receptor, IL 7R a, IL 7R subunit alpha, IL 7R a, IL 7Ra, IL 7Ra, IL7 receptor, IL-7 receptor alpha chain, IL7 receptor subunit alpha, IL-7 receptor subunit alpha, IL7R, IL-7R, IL7R a, IL7R alpha, IL7R subunit alpha, IL-7R subunit alpha, IL7R a, IL7RA, IL-7RA, IL-7Ralpha, IL-7R-alpha, IL7Ra, ILRA, interleukin 7 receptor, interleukin 7 receptor alpha chain, interleukin 7 receptor isoform H5-6, Interleukin7 receptor subunit alpha, interleukin-7 receptor subunit alpha, MGC107557, sCD127, soluble IL 7 receptor, soluble IL 7R
Host Species: Rat
Quantity: 25 μg
Primary or Secondary: Primary
Target Species: Mouse
Product Type: Antibody
Isotype: IgG2a κ
Antigen:
CD127
Classification:
Monoclonal
Concentration:
0.2 mg/mL
Formulation:
PBS with 0.09% sodium azide, pH 7.2
Gene Accession No.:
P16872
Gene Symbols:
Il7r
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
16197
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Form:
Liquid
Applications:
Flow Cytometry
Clone:
A7R34
Conjugate:
PerCP-eFluor 710
Gene:
Il7r
Gene Alias:
CD127, CD127 antigen, CDW127, IL 7 receptor, IL 7R a, IL 7R subunit alpha, IL 7R a, IL 7Ra, IL 7Ra, IL7 receptor, IL-7 receptor alpha chain, IL7 receptor subunit alpha, IL-7 receptor subunit alpha, IL7R, IL-7R, IL7R a, IL7R alpha, IL7R subunit alpha, IL-7R subunit alpha, IL7R a, IL7RA, IL-7RA, IL-7Ralpha, IL-7R-alpha, IL7Ra, ILRA, interleukin 7 receptor, interleukin 7 receptor alpha chain, interleukin 7 receptor isoform H5-6, Interleukin7 receptor subunit alpha, interleukin-7 receptor subunit alpha, MGC107557, sCD127, soluble IL 7 receptor, soluble IL 7R
Host Species:
Rat
Quantity:
25 μg
Primary or Secondary:
Primary
Target Species:
Mouse
Product Type:
Antibody
Isotype:
IgG2a κ
Antigen: CD127
Classification: Monoclonal
Concentration: 0.2 mg/mL
Formulation: PBS with 0.09% sodium azide, pH 7.2
Gene Accession No.: P16872
Gene Symbols: Il7r
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 16197
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Form: Liquid
Applications: Flow Cytometry
Clone: A7R34
Conjugate: PerCP-eFluor 710
Gene: Il7r
Gene Alias: CD127, CD127 antigen, CDW127, IL 7 receptor, IL 7R a, IL 7R subunit alpha, IL 7R a, IL 7Ra, IL 7Ra, IL7 receptor, IL-7 receptor alpha chain, IL7 receptor subunit alpha, IL-7 receptor subunit alpha, IL7R, IL-7R, IL7R a, IL7R alpha, IL7R subunit alpha, IL-7R subunit alpha, IL7R a, IL7RA, IL-7RA, IL-7Ralpha, IL-7R-alpha, IL7Ra, ILRA, interleukin 7 receptor, interleukin 7 receptor alpha chain, interleukin 7 receptor isoform H5-6, Interleukin7 receptor subunit alpha, interleukin-7 receptor subunit alpha, MGC107557, sCD127, soluble IL 7 receptor, soluble IL 7R
Host Species: Rat
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Mouse
Product Type: Antibody
Isotype: IgG2a κ
Antigen:
CD127
Classification:
Monoclonal
Concentration:
0.2 mg/mL
Formulation:
PBS with 0.09% sodium azide, pH 7.2
Gene Accession No.:
P16872
Gene Symbols:
Il7r
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
16197
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Form:
Liquid
Applications:
Flow Cytometry
Clone:
A7R34
Conjugate:
PerCP-eFluor 710
Gene:
Il7r
Gene Alias:
CD127, CD127 antigen, CDW127, IL 7 receptor, IL 7R a, IL 7R subunit alpha, IL 7R a, IL 7Ra, IL 7Ra, IL7 receptor, IL-7 receptor alpha chain, IL7 receptor subunit alpha, IL-7 receptor subunit alpha, IL7R, IL-7R, IL7R a, IL7R alpha, IL7R subunit alpha, IL-7R subunit alpha, IL7R a, IL7RA, IL-7RA, IL-7Ralpha, IL-7R-alpha, IL7Ra, ILRA, interleukin 7 receptor, interleukin 7 receptor alpha chain, interleukin 7 receptor isoform H5-6, Interleukin7 receptor subunit alpha, interleukin-7 receptor subunit alpha, MGC107557, sCD127, soluble IL 7 receptor, soluble IL 7R
Host Species:
Rat
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Mouse
Product Type:
Antibody
Isotype:
IgG2a κ
Antigen: CD127
Classification: Monoclonal
Concentration: 5 μL/Test
Formulation: PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.: P16871
Gene Symbols: Il7r
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 3575
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Form: Liquid
Applications: Flow Cytometry
Clone: eBioRDR5
Conjugate: PerCP-eFluor 710
Gene: Il7r
Gene Alias: CD127; CD127 antigen; CDW127; IL 7 receptor; IL 7R a; IL 7R subunit alpha; IL 7R a; IL 7Ra; IL 7Ra; IL7 receptor; IL-7 receptor alpha chain; IL7 receptor subunit alpha; IL-7 receptor subunit alpha; IL7R; IL-7R; IL7R a; IL7R alpha; IL7R subunit alpha; IL-7R subunit alpha; IL7R a; IL7RA; IL-7RA; IL-7Ralpha; IL-7R-alpha; IL7Ra; ILRA; interleukin 7 receptor; interleukin 7 receptor alpha chain; interleukin 7 receptor isoform H5-6; Interleukin7 receptor subunit alpha; interleukin-7 receptor subunit alpha; MGC107557; sCD127; soluble IL 7 receptor; soluble IL 7R
Host Species: Mouse
Quantity: 100 Tests
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1 κ
Antigen:
CD127
Classification:
Monoclonal
Concentration:
5 μL/Test
Formulation:
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.:
P16871
Gene Symbols:
Il7r
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
3575
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Form:
Liquid
Applications:
Flow Cytometry
Clone:
eBioRDR5
Conjugate:
PerCP-eFluor 710
Gene:
Il7r
Gene Alias:
CD127; CD127 antigen; CDW127; IL 7 receptor; IL 7R a; IL 7R subunit alpha; IL 7R a; IL 7Ra; IL 7Ra; IL7 receptor; IL-7 receptor alpha chain; IL7 receptor subunit alpha; IL-7 receptor subunit alpha; IL7R; IL-7R; IL7R a; IL7R alpha; IL7R subunit alpha; IL-7R subunit alpha; IL7R a; IL7RA; IL-7RA; IL-7Ralpha; IL-7R-alpha; IL7Ra; ILRA; interleukin 7 receptor; interleukin 7 receptor alpha chain; interleukin 7 receptor isoform H5-6; Interleukin7 receptor subunit alpha; interleukin-7 receptor subunit alpha; MGC107557; sCD127; soluble IL 7 receptor; soluble IL 7R
Host Species:
Mouse
Quantity:
100 Tests
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1 κ