FceR1 alpha Monoclonal Antibody (MAR-1), APC-eFluor™ 780, eBioscience™, Invitrogen™

Description

• Description The MAR-1 MAb reacts with the Fc epsilon Receptor I alpha subunit, an IgE-binding subunit lacking signal-transducing ability
• Fc epsilon RI alpha is expressed on mast and basophil cells and is up-regulated by the presence of IgE
• Fc epsilon RI alpha forms a tetrameric complex with one beta and two gamma subunits
• The beta and gamma subunits possess immunoreceptor tyrosine-based activation motifs (ITAM)
• The Fc epsilon RI complex plays an important role in triggering IgE-mediated allergic reactions
• FceR1 (Fc epsilonR1 alpha) is a subunit of the high affinity receptor of IgE
• Fc epsilonR1 alpha is a tetrameric complex consisting of one alpha, one β and two additional subunits
• The latter two are required for signal transduction activity
• The Fc epsilonR1 complex plays an important role in triggering allergic responses, and the immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response
• When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine, which are responsible for allergy symptoms, are released
• The IgE receptor couples allergen and mast cells to initiate the inflammatory responses that are characteristic of disorders such as hay fever and asthma
• The release of histamine and proteases leads to the synthesis of prostaglandins and leukotrienes-potent effectors of the hypersensitivity response.