48-972-582
COX2 Monoclonal Antibody (COX 229), eFluor™ 450, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 48-972-582-Each-of-1 | In Stock | ₹ 16,085.28 |
48-972-582 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 16,085.28
GST (18%): ₹ 2,895.35
Total Price: ₹ 18,980.63
Antigen
COX2
Classification
Monoclonal
Concentration
0.2 mg/mL
Formulation
PBS with 0.09% sodium azide, pH 7.2
Gene Accession No.
P35354
Gene Symbols
PTGS2
Immunogen
Synthetic peptide from human COX2
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1 κ
Applications
Flow Cytometry
Clone
COX 229
Conjugate
eFluor 450
Gene
PTGS2
Gene Alias
COII, COX2, Cox-2, COXII, cyclooxygenase, cyclooxygenase 2, cyclooxygenase 2b, cyclooxygenase-2, Cytochrome c oxidase polypeptide II, Cytochrome c oxidase subunit 2, cytochrome c oxidase subunit II, glucocorticoid-regulated inflammatory cyclooxygenase, Gripghs, hCox-2, Macrophage activation-associated marker protein P71/73, mitochondrially encoded cytochrome c oxidase II, MTCO2, MT-CO2, PES-2, PGG/HS, PGH synthase 2, Pghs2, PGHS-2, Pghs-b, PHS II, PHS-2, prostaglandin G/H synthase 2, Prostaglandin H2 synthase 2, prostaglandin-endoperoxide synthase 2, prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase), Ptgs2, Tis10, TIS10 protein
Host Species
Mouse
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
5743
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Related Products
Description
- Description: This COX 229 monoclonal antibody recognizes human COX2 also known as PTGS2
- This antibody has been reported to cross-react with the mouse and rat COX2
- For optimal performance we recommend using this antibody with the Foxp3 / Transcription Factor Staining Buffer Set and protocol
- This antibody is predicted to cross-react with the mouse and rat homologue
- Applications Reported: This COX 229 antibody has been reported for use in intracellular staining followed by flow cytometric analysis
- Applications Tested: This COX 229 antibody has been tested by intracellular staining followed by flow cytometric analysis of stimulated normal human peripheral blood cells using the Foxp3/Transcription Factor Staining Buffer Set (Product No
- 00-5523-00) and protocol
- Please refer to Staining Intracellular Antigens for Flow Cytometry, Protocol B: One step protocol for intracellular (nuclear) proteins located at www.thermofisher.com/flowprotocols
- This may be used at less than or equal to 0.125 μg per test
- A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
- Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
- It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest
- eFluor 450 is an alternative to Pacific Blue
- COX2 converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis, including production of inflammatory prostaglandins
- The conversion of arachidonate to prostaglandin H2 is a 2 step reaction: a cyclooxygenase (COX) reaction which converts arachidonate to prostaglandin G2 (PGG2) and a peroxidase reaction in which PGG2 is reduced to prostaglandin H2 (PGH2)
- It is constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and is up-regulated under pathological conditions, such as in cancer and inflammation (in contrast to the iso-enzyme PTGS1, which is expressed ubiquitously)
- Up-regulation of COX2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis
- In cancer cells, COX2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis
- COX2 is naturally inhibited by calcitriol (the active form of Vitamin D)
- Glucocorticoids chronically trans-repress PTGS2 gene activity in vivo in part by interfering with transcription initiation and elongation
- COX2 is a target of NSAID such as aspirin, which can reduce pain and swelling from inflammation driven by COX2.
Compare Similar Items
Show Difference
Antigen: COX2
Classification: Monoclonal
Concentration: 0.2 mg/mL
Formulation: PBS with 0.09% sodium azide, pH 7.2
Gene Accession No.: P35354
Gene Symbols: PTGS2
Immunogen: Synthetic peptide from human COX2
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1 κ
Applications: Flow Cytometry
Clone: COX 229
Conjugate: eFluor 450
Gene: PTGS2
Gene Alias: COII, COX2, Cox-2, COXII, cyclooxygenase, cyclooxygenase 2, cyclooxygenase 2b, cyclooxygenase-2, Cytochrome c oxidase polypeptide II, Cytochrome c oxidase subunit 2, cytochrome c oxidase subunit II, glucocorticoid-regulated inflammatory cyclooxygenase, Gripghs, hCox-2, Macrophage activation-associated marker protein P71/73, mitochondrially encoded cytochrome c oxidase II, MTCO2, MT-CO2, PES-2, PGG/HS, PGH synthase 2, Pghs2, PGHS-2, Pghs-b, PHS II, PHS-2, prostaglandin G/H synthase 2, Prostaglandin H2 synthase 2, prostaglandin-endoperoxide synthase 2, prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase), Ptgs2, Tis10, TIS10 protein
Host Species: Mouse
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 5743
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Form: Liquid
Antigen:
COX2
Classification:
Monoclonal
Concentration:
0.2 mg/mL
Formulation:
PBS with 0.09% sodium azide, pH 7.2
Gene Accession No.:
P35354
Gene Symbols:
PTGS2
Immunogen:
Synthetic peptide from human COX2
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1 κ
Applications:
Flow Cytometry
Clone:
COX 229
Conjugate:
eFluor 450
Gene:
PTGS2
Gene Alias:
COII, COX2, Cox-2, COXII, cyclooxygenase, cyclooxygenase 2, cyclooxygenase 2b, cyclooxygenase-2, Cytochrome c oxidase polypeptide II, Cytochrome c oxidase subunit 2, cytochrome c oxidase subunit II, glucocorticoid-regulated inflammatory cyclooxygenase, Gripghs, hCox-2, Macrophage activation-associated marker protein P71/73, mitochondrially encoded cytochrome c oxidase II, MTCO2, MT-CO2, PES-2, PGG/HS, PGH synthase 2, Pghs2, PGHS-2, Pghs-b, PHS II, PHS-2, prostaglandin G/H synthase 2, Prostaglandin H2 synthase 2, prostaglandin-endoperoxide synthase 2, prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase), Ptgs2, Tis10, TIS10 protein
Host Species:
Mouse
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
5743
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Form:
Liquid
Antigen: Sall1
Classification: Monoclonal
Concentration: 0.2 mg/mL
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.: Q9ER74
Gene Symbols: SALL1
Immunogen: C-terminal fragment of the protein (aa-805-1322)
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Mouse
Product Type: Antibody
Isotype: IgG2a κ
Applications: Flow Cytometry
Clone: NRNSTNX
Conjugate: eFluor 450
Gene: SALL1
Gene Alias: epididymis secretory protein Li 89; HEL-S-89; HSal1; Msal-3; SAL1; Sal-1; sal-3; SALL1; sal-like 1; sal-like 1 (Drosophila); sal-like protein 1; spalt like transcription factor 1; spalt-like transcription factor 1; TBS; Zinc finger protein 794; zinc finger protein SALL1; Zinc finger protein Spalt-1; zinc finger protein Spalt-3; ZNF794
Host Species: Rat
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 58198
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Form: Liquid
Antigen:
Sall1
Classification:
Monoclonal
Concentration:
0.2 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
Q9ER74
Gene Symbols:
SALL1
Immunogen:
C-terminal fragment of the protein (aa-805-1322)
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Mouse
Product Type:
Antibody
Isotype:
IgG2a κ
Applications:
Flow Cytometry
Clone:
NRNSTNX
Conjugate:
eFluor 450
Gene:
SALL1
Gene Alias:
epididymis secretory protein Li 89; HEL-S-89; HSal1; Msal-3; SAL1; Sal-1; sal-3; SALL1; sal-like 1; sal-like 1 (Drosophila); sal-like protein 1; spalt like transcription factor 1; spalt-like transcription factor 1; TBS; Zinc finger protein 794; zinc finger protein SALL1; Zinc finger protein Spalt-1; zinc finger protein Spalt-3; ZNF794
Host Species:
Rat
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
58198
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Form:
Liquid
Antigen: MAVS
Classification: Monoclonal
Concentration: 5 μL/Test
Formulation: PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.: Q7Z434
Gene Symbols: MAVS
Immunogen: Recombinant fragment of human MAVS (aa 72-296)
Quantity: 100 Tests
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG2b κ
Applications: Flow Cytometry
Clone: ABM28H9
Conjugate: eFluor 450
Gene: MAVS
Gene Alias: CARD adapter inducing interferon beta; CARD adaptor inducing IFN-beta; Cardif; D430028G21Rik; IFN-B promoter stimulator 1; IFN-beta promoter stimulator-1; interferon beta promoter stimulator protein 1; interferon-beta promoter stimulator protein 1; IPS1; IPS-1; KIAA1271; MAVS; mitochondrial antiviral signaling protein; mitochondrial anti-viral signaling protein; mitochondrial antiviral-signaling protein; Putative NF-kappa-B-activating protein 031N; virus-induced signaling adapter; virus-induced signaling adaptor; virus-induced-signaling adapter; VISA
Host Species: Mouse
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 57506
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Form: Liquid
Antigen:
MAVS
Classification:
Monoclonal
Concentration:
5 μL/Test
Formulation:
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.:
Q7Z434
Gene Symbols:
MAVS
Immunogen:
Recombinant fragment of human MAVS (aa 72-296)
Quantity:
100 Tests
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG2b κ
Applications:
Flow Cytometry
Clone:
ABM28H9
Conjugate:
eFluor 450
Gene:
MAVS
Gene Alias:
CARD adapter inducing interferon beta; CARD adaptor inducing IFN-beta; Cardif; D430028G21Rik; IFN-B promoter stimulator 1; IFN-beta promoter stimulator-1; interferon beta promoter stimulator protein 1; interferon-beta promoter stimulator protein 1; IPS1; IPS-1; KIAA1271; MAVS; mitochondrial antiviral signaling protein; mitochondrial anti-viral signaling protein; mitochondrial antiviral-signaling protein; Putative NF-kappa-B-activating protein 031N; virus-induced signaling adapter; virus-induced signaling adaptor; virus-induced-signaling adapter; VISA
Host Species:
Mouse
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
57506
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Form:
Liquid
Antigen: c-MAF
Classification: Monoclonal
Concentration: 5 μL/Test
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.: O75444, P54843
Gene Symbols: MAF
Immunogen: Full-length E. coli-produced c-Maf
Quantity: 100 Tests
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG2b κ
Applications: Flow Cytometry
Clone: sym0F1
Conjugate: eFluor 450
Gene: MAF
Gene Alias: 2810401A20Rik; A230108G15Rik; Avian musculoaponeurotic fibrosarcoma (MAF) protooncogene; avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog; AW047063; AYGRP; basic domain leucine zipper transcription factor; CCA4; cMaf; C-Maf; c-Maf long form; c-maf proto-oncogene; CTRCT21; fl13d12; hMafA; LOW QUALITY PROTEIN: transcription factor Maf; LOW QUALITY PROTEIN: transcription factor MafA; maf; MAF bZIP transcription factor; MAF bZIP transcription factor A; maf protein; Maf2; MAFA; Mafa homolog; MGC71685; pancreatic beta-cell-specific transcriptional activator; Proto-oncogene c-Maf; RGD1562627; RIPE3b1; RIPE3b1 factor; T lymphocyte c-maf long form; transcription factor Maf; Transcription factor Maf-2; transcription factor MafA; transcription factor RIPE3b1; v-maf avian musculoaponeurotic fibrosarcoma oncogene A; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog a (paralog a); v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A; v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian); v-maf musculoaponeurotic fibrosarcoma oncogene homolog; V-maf musculoaponeurotic fibrosarcoma oncogene homolog A; wu:fl13d12; Z-cmaf
Host Species: Mouse
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 17132, 4094
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Form: Liquid
Antigen:
c-MAF
Classification:
Monoclonal
Concentration:
5 μL/Test
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
O75444, P54843
Gene Symbols:
MAF
Immunogen:
Full-length E. coli-produced c-Maf
Quantity:
100 Tests
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG2b κ
Applications:
Flow Cytometry
Clone:
sym0F1
Conjugate:
eFluor 450
Gene:
MAF
Gene Alias:
2810401A20Rik; A230108G15Rik; Avian musculoaponeurotic fibrosarcoma (MAF) protooncogene; avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog; AW047063; AYGRP; basic domain leucine zipper transcription factor; CCA4; cMaf; C-Maf; c-Maf long form; c-maf proto-oncogene; CTRCT21; fl13d12; hMafA; LOW QUALITY PROTEIN: transcription factor Maf; LOW QUALITY PROTEIN: transcription factor MafA; maf; MAF bZIP transcription factor; MAF bZIP transcription factor A; maf protein; Maf2; MAFA; Mafa homolog; MGC71685; pancreatic beta-cell-specific transcriptional activator; Proto-oncogene c-Maf; RGD1562627; RIPE3b1; RIPE3b1 factor; T lymphocyte c-maf long form; transcription factor Maf; Transcription factor Maf-2; transcription factor MafA; transcription factor RIPE3b1; v-maf avian musculoaponeurotic fibrosarcoma oncogene A; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog a (paralog a); v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A; v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian); v-maf musculoaponeurotic fibrosarcoma oncogene homolog; V-maf musculoaponeurotic fibrosarcoma oncogene homolog A; wu:fl13d12; Z-cmaf
Host Species:
Mouse
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
17132, 4094
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Form:
Liquid