CD7 Monoclonal Antibody (eBio124-1D1 (124-1D1)), APC, eBioscience™, Invitrogen™

Description

• Description: The eBio124-1D1 monoclonal antibody reacts with human CD7, also known as gp40 and Leu9
• CD7, a 40 kD receptor, is a member of the immunoglobulin gene superfamily
• The N-terminal amino acid sequence (aa1-107) is highly homologous to Ig kappa light chain sequence; while the carboxyl-terminal region of the extracellular domain is proline-rich and has been postulated to form a stalk from which the Ig domain projects
• CD7 is expressed on the majority of immature and mature T lymphocytes, and T cell leukemias
• It is also found on natural killer cells, a small suppopulation of normal B cells and on maligant B cells
• Cross-linking surface CD7 positively modulates T cell and NK cell activity, as measured by calcium flux, expression of adhesion molecules, cytokine secretion and proliferation
• CD7 associates directly with phosphoinositol 3'-kinase
• CD7 ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation
• A clonogenic subpopulation of human CD34(+) CD38(-) cord blood cells that express CD45RA and HLA-DR and high levels of the CD7 has been reported
• These cells possess the capacity for lymphopoiesis
• They can generate B-cells, natural killer cells, and dendritic cells but do not possess the capacity to develop into myeloid cells or erythroid cells
• The CD7(+) phenotype distinguishes primitive human lymphoid progenitors from pluripotent stem cells
• CD7 (gp40, Leu9) is a 40 kDa member of the immunoglobulin gene superfamily
• CD7 contains N-terminal amino acids 1-107 are highly homologous to Ig kappa-L chains whereas the carboxy-terminal region of the extracellular domain is proline-rich and has been postulated to form a stalk from which the Ig domain projects
• CD7 is expressed on the majority of immature and mature T-lymphocytes, and T cell leukemia
• Further, CD7 is also found on natural killer cells, a small subpopulation of normal B cells and on malignant B cells
• Cross-linking surface CD7 positively modulates T cell and NK cell activity as measured by calcium fluxes, expression of adhesion molecules, cytokine secretion and proliferation
• CD7 associates directly with phosphoinositol 3'-kinase
• CD7 ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation
• Expression of CD7 is an important marker used in leukemia diagnostics.