50-112-3976
IRF4 Monoclonal Antibody (3E4), PerCP-eFluor™ 710, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-112-3976-Each-of-1 | In Stock | ₹ 35,421.84 |
50-112-3976 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 35,421.84
GST (18%): ₹ 6,375.931
Total Price: ₹ 41,797.771
Antigen
IRF4
Classification
Monoclonal
Concentration
0.2 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
Q15306, Q64287
Gene Symbols
IRF4
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
16364, 3662
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
3E4
Conjugate
PerCP-eFluor 710
Gene
IRF4
Gene Alias
AI385587; interferon regulatory factor 4; Irf4; IRF-4; LSIRF; Lymphocyte-specific interferon regulatory factor; multiple myeloma oncogene 1; MUM1; NF-EM5; PU.1 interaction partner; Sfpi1/PU.1 interaction partner; SHEP8; Spip; Transcriptional activator PIP
Host Species
Rat
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG1 κ
Related Products
Description
- Description: The monoclonal antibody 3E4 reacts with human and mouse interferon regulatory factor 4 (IRF4)
- IRF4 is a 52 kDa transcription factor with roles in B cell, T cell and macrophage function
- In B cells, IRF4 is highly expressed in mature plasma cells and plays a crucial role in their differentiation
- IRF4 has been shown to interact with PU.1 and control the transcription of many B cell-specific genes including Prdm1, which encodes Blimp1
- In T cells, IRF4 has been implicated in regulatory T (Treg), Th2, Th9 and Th17 cell development and function
- This transcription factor is upregulated upon T cell activation and is expressed in mature T cells
- Studies have shown that IRF4 directly induces Blimp1 expression in Tregs, leading to IL-10 expression
- IRF4 has also been demonstrated to be involved in macrophage polarization and regulation
- Lastly, in addition to its roles in normal immune function, IRF4 expression has been reported to be upregulated in many blood-related cancers
- Applications Reported: This 3E4 antibody has been reported for use in intracellular staining followed by flow cytometric analysis
- Applications Tested: This 3E4 antibody has been tested by intracellular staining and flow cytometric analysis of stimulated normal human peripheral blood cells using the Foxp3/Transcription Factor Buffer Set (cat 00-5523) and protocol
- The IRF (interferon regulatory factor) family of transcription factors are characterized by an unique tryptophan pentad repeat DNA-binding domain
- The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes
- IRF4 is lymphocyte specific and negatively regulates toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems
- A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma
- Alternatively spliced transcript variants have been found.
Compare Similar Items
Show Difference
Antigen: IRF4
Classification: Monoclonal
Concentration: 0.2 mg/mL
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.: Q15306, Q64287
Gene Symbols: IRF4
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 16364, 3662
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Form: Liquid
Applications: Flow Cytometry
Clone: 3E4
Conjugate: PerCP-eFluor 710
Gene: IRF4
Gene Alias: AI385587; interferon regulatory factor 4; Irf4; IRF-4; LSIRF; Lymphocyte-specific interferon regulatory factor; multiple myeloma oncogene 1; MUM1; NF-EM5; PU.1 interaction partner; Sfpi1/PU.1 interaction partner; SHEP8; Spip; Transcriptional activator PIP
Host Species: Rat
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG1 κ
Antigen:
IRF4
Classification:
Monoclonal
Concentration:
0.2 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
Q15306, Q64287
Gene Symbols:
IRF4
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
16364, 3662
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Form:
Liquid
Applications:
Flow Cytometry
Clone:
3E4
Conjugate:
PerCP-eFluor 710
Gene:
IRF4
Gene Alias:
AI385587; interferon regulatory factor 4; Irf4; IRF-4; LSIRF; Lymphocyte-specific interferon regulatory factor; multiple myeloma oncogene 1; MUM1; NF-EM5; PU.1 interaction partner; Sfpi1/PU.1 interaction partner; SHEP8; Spip; Transcriptional activator PIP
Host Species:
Rat
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG1 κ
Antigen: Phospho-Histone H2A.X (Ser139)
Classification: Monoclonal
Concentration: 5 μL/Test
Formulation: PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.: P16104, P27661
Gene Symbols: H2AX
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 15270, 3014
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Form: Liquid
Applications: Flow Cytometry
Clone: CR55T33
Conjugate: PerCP-eFluor 710
Gene: H2AX
Gene Alias: AW228881; gamma H2AX; gammaH2ax; H2A histone family member X; H2A histone family, member X; H2A.X; H2A.X variant histone; H2A/X; h2afx; H2ax; H2AX histone; Hist5-2ax; histone 5 protein 2ax; histone H2A.x; Histone H2a/x; Histone H2AX; RGD1566119; similar to H2A histone family, member X; zgc:56329
Host Species: Mouse
Quantity: 100 Tests
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG1 κ
Antigen:
Phospho-Histone H2A.X (Ser139)
Classification:
Monoclonal
Concentration:
5 μL/Test
Formulation:
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.:
P16104, P27661
Gene Symbols:
H2AX
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
15270, 3014
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Form:
Liquid
Applications:
Flow Cytometry
Clone:
CR55T33
Conjugate:
PerCP-eFluor 710
Gene:
H2AX
Gene Alias:
AW228881; gamma H2AX; gammaH2ax; H2A histone family member X; H2A histone family, member X; H2A.X; H2A.X variant histone; H2A/X; h2afx; H2ax; H2AX histone; Hist5-2ax; histone 5 protein 2ax; histone H2A.x; Histone H2a/x; Histone H2AX; RGD1566119; similar to H2A histone family, member X; zgc:56329
Host Species:
Mouse
Quantity:
100 Tests
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG1 κ
Antigen: IgD
Classification: Monoclonal
Concentration: 5 μL/Test
Formulation: PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.: P01880
Gene Symbols: IGHD
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 3495
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Form: Liquid
Applications: Flow Cytometry
Clone: IA6-2
Conjugate: PerCP-eFluor 710
Gene: IGHD
Gene Alias: IGHD; immunoglobulin heavy constant delta
Host Species: Mouse
Quantity: 100 Tests
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG2a κ
Antigen:
IgD
Classification:
Monoclonal
Concentration:
5 μL/Test
Formulation:
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.:
P01880
Gene Symbols:
IGHD
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
3495
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Form:
Liquid
Applications:
Flow Cytometry
Clone:
IA6-2
Conjugate:
PerCP-eFluor 710
Gene:
IGHD
Gene Alias:
IGHD; immunoglobulin heavy constant delta
Host Species:
Mouse
Quantity:
100 Tests
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG2a κ
Antigen: TCR gamma/delta
Classification: Monoclonal
Concentration: 5 μL/Test
Formulation: PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.: 0
Gene Symbols: TRD, Trg
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 6964, 6965
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Form: Liquid
Applications: Flow Cytometry
Clone: B1.1
Conjugate: PerCP-eFluor 710
Gene: TRD
Gene Alias: RGD1311300; similar to T cell receptor V delta 6; T cell receptor gamma locus; T3/TCR complex; TCR delta gamma; TCR gamma/delta; TCR-CD3 complex; Tcrg; Trg; Trg@
Host Species: Mouse
Quantity: 25 Tests
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1 κ
Antigen:
TCR gamma/delta
Classification:
Monoclonal
Concentration:
5 μL/Test
Formulation:
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.:
0
Gene Symbols:
TRD, Trg
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
6964, 6965
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Form:
Liquid
Applications:
Flow Cytometry
Clone:
B1.1
Conjugate:
PerCP-eFluor 710
Gene:
TRD
Gene Alias:
RGD1311300; similar to T cell receptor V delta 6; T cell receptor gamma locus; T3/TCR complex; TCR delta gamma; TCR gamma/delta; TCR-CD3 complex; Tcrg; Trg; Trg@
Host Species:
Mouse
Quantity:
25 Tests
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1 κ