50-112-8746
CD278 (ICOS) Monoclonal Antibody (ISA-3), Functional Grade, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-112-8746-Each-of-1 | In Stock | ₹ 34,052.88 |
50-112-8746 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 34,052.88
GST (18%): ₹ 6,129.518
Total Price: ₹ 40,182.398
Antigen
CD278 (ICOS)
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with no preservative; pH 7.2
Gene Accession No.
Q9Y6W8
Gene Symbols
ICOS
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
29851
Content And Storage
4° C
Form
Liquid
Applications
Flow Cytometry, Functional Assay
Clone
ISA-3
Conjugate
Functional Grade
Gene
ICOS
Gene Alias
Activation-inducible lymphocyte immunomediatory molecule; Ailim; CCLP; CD278; CD28 and CTLA-4-like protein; CD28-related protein 1; CRP-1; CVID1; H4; Icos; inducible costimulator; inducible T cell costimulator; inducible T cell co-stimulator; inducible T-cell costimulator; inducible T-cell co-stimulator; Ly115
Host Species
Mouse
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1 κ
Related Products
Description
- The ISA-3 MAb reacts with human ICOS (Inducible COStimulatory molecule), also known as H4, CRP-1 and AILIM
- ICOS is a T cell specific activation molecule and a third member of the CD28/CTLA-4 family
- Human ICOS has a relative molecular mass of 55-60 kDa, composed of 27 kDa and 29 kDa chains
- Human ICOS on activated T cells has potent costimulatory activity for T cell activation and is required for humoral immune responses, in particular for memory B cell and plasma cell generation
- ICOS binds to its ligand, B7h/B7RP-1 expressed on activated APCs (antigen presenting cells) and on a number of inflamed peripheral tissues
- Plate-bound ISA-3 is costimulatory for T cells and induces production of IL-4, IL-5, IL-10 and other cytokines, but not IL-2
- ISA-3 has the same reactivity pattern and characteristics as F44
- ISA-3 was generated against the human ICOS antigen
- C398.4A, anti-mouse ICOS/H4 (catalog # 14-9949-82), was shown to cross-react with human ICOS but binds to an epitope different from ISA-3
- C398.4A stains activated cells brighter than ISA-3; however, it also exhibits higher staining of non-activated human peripheral blood or isolated PBMC
- To achieve the brightest staining of ICOS on activated human T cells, please use 13-9948-82 or 12-9948-42 rather than 11-9948-42
- ICOS (CD278) encodes a protein that is a member of the CD28 and CTLA-4 cell-surface receptor family
- It functions as a homodimer and has a crucial role in cell-cell signaling, immune responses, and the regulation of cell proliferation
- ICOS has been linked to various disorders, including Immunodeficiency, Common Variable, 1 and Common Variable Immunodeficiency.
Compare Similar Items
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Antigen: CD278 (ICOS)
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with no preservative; pH 7.2
Gene Accession No.: Q9Y6W8
Gene Symbols: ICOS
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 29851
Content And Storage: 4° C
Form: Liquid
Applications: Flow Cytometry, Functional Assay
Clone: ISA-3
Conjugate: Functional Grade
Gene: ICOS
Gene Alias: Activation-inducible lymphocyte immunomediatory molecule; Ailim; CCLP; CD278; CD28 and CTLA-4-like protein; CD28-related protein 1; CRP-1; CVID1; H4; Icos; inducible costimulator; inducible T cell costimulator; inducible T cell co-stimulator; inducible T-cell costimulator; inducible T-cell co-stimulator; Ly115
Host Species: Mouse
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1 κ
Antigen:
CD278 (ICOS)
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with no preservative; pH 7.2
Gene Accession No.:
Q9Y6W8
Gene Symbols:
ICOS
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
29851
Content And Storage:
4° C
Form:
Liquid
Applications:
Flow Cytometry, Functional Assay
Clone:
ISA-3
Conjugate:
Functional Grade
Gene:
ICOS
Gene Alias:
Activation-inducible lymphocyte immunomediatory molecule; Ailim; CCLP; CD278; CD28 and CTLA-4-like protein; CD28-related protein 1; CRP-1; CVID1; H4; Icos; inducible costimulator; inducible T cell costimulator; inducible T cell co-stimulator; inducible T-cell costimulator; inducible T-cell co-stimulator; Ly115
Host Species:
Mouse
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1 κ
Antigen: Mouse IgG2a kappa
Classification: __
Concentration: 5 μL/Test
Formulation: PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.: __
Gene Symbols: __
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): __
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Form: Liquid
Applications: Control, Flow Cytometry
Clone: eBM2a
Conjugate: PE
Gene: __
Gene Alias: IgG2; Immunoglobulin G; Immunoglobulin G2; ImmunoglobulinG; ImmunoglobulinG2
Host Species: Mouse
Quantity: 100 Tests
Primary or Secondary: Isotype Control (Primary)
Target Species: Not Applicable
Product Type: __
Isotype: IgG2a κ
Antigen:
Mouse IgG2a kappa
Classification:
__
Concentration:
5 μL/Test
Formulation:
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.:
__
Gene Symbols:
__
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
__
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Form:
Liquid
Applications:
Control, Flow Cytometry
Clone:
eBM2a
Conjugate:
PE
Gene:
__
Gene Alias:
IgG2; Immunoglobulin G; Immunoglobulin G2; ImmunoglobulinG; ImmunoglobulinG2
Host Species:
Mouse
Quantity:
100 Tests
Primary or Secondary:
Isotype Control (Primary)
Target Species:
Not Applicable
Product Type:
__
Isotype:
IgG2a κ
Antigen: CD274 (PD-L1, B7-H1)
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.: Q9NZQ7
Gene Symbols: Cd274
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 29126
Content And Storage: 4° C, do not freeze
Form: Liquid
Applications: Flow Cytometry
Clone: MIH1
Conjugate: Biotin
Gene: Cd274
Gene Alias: A530045L16Rik; B7 homolog 1; B7-H; B7h1; B7-H1; Cd274; CD274 antigen; CD274 molecule; PDCD1 ligand 1; Pdcd1l1; Pdcd1lg1; Pdl1; PD-L1; pdl-1; Programmed cell death 1 ligand 1; programmed death ligand 1; RGD1566211; sCD274; soluble CD274; soluble PD L1; sPD L1
Host Species: Mouse
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1 κ
Antigen:
CD274 (PD-L1, B7-H1)
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
Q9NZQ7
Gene Symbols:
Cd274
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
29126
Content And Storage:
4° C, do not freeze
Form:
Liquid
Applications:
Flow Cytometry
Clone:
MIH1
Conjugate:
Biotin
Gene:
Cd274
Gene Alias:
A530045L16Rik; B7 homolog 1; B7-H; B7h1; B7-H1; Cd274; CD274 antigen; CD274 molecule; PDCD1 ligand 1; Pdcd1l1; Pdcd1lg1; Pdl1; PD-L1; pdl-1; Programmed cell death 1 ligand 1; programmed death ligand 1; RGD1566211; sCD274; soluble CD274; soluble PD L1; sPD L1
Host Species:
Mouse
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1 κ
Antigen: CD273 (B7-DC)
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.: Q9BQ51
Gene Symbols: PDCD1LG2
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 80380
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Form: Liquid
Applications: Flow Cytometry
Clone: MIH18
Conjugate: Biotin
Gene: PDCD1LG2
Gene Alias: B7 dendritic cell molecule; B7DC; B7-DC; bA574F11.2; Btdc; Butyrophilin B7-DC; butyrophilin-like protein; CD273; F730015O22Rik; MGC124039; MGC124040; PD1 ligand 2; PD-1 ligand 2; PD-1-ligand 2; PDCD1 ligand 2; PDCD1L2; Pdcd1lg2; Pdl2; PD-L2; Programmed cell death 1 ligand 2; programmed death ligand 2
Host Species: Mouse
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1 κ
Antigen:
CD273 (B7-DC)
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
Q9BQ51
Gene Symbols:
PDCD1LG2
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
80380
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Form:
Liquid
Applications:
Flow Cytometry
Clone:
MIH18
Conjugate:
Biotin
Gene:
PDCD1LG2
Gene Alias:
B7 dendritic cell molecule; B7DC; B7-DC; bA574F11.2; Btdc; Butyrophilin B7-DC; butyrophilin-like protein; CD273; F730015O22Rik; MGC124039; MGC124040; PD1 ligand 2; PD-1 ligand 2; PD-1-ligand 2; PDCD1 ligand 2; PDCD1L2; Pdcd1lg2; Pdl2; PD-L2; Programmed cell death 1 ligand 2; programmed death ligand 2
Host Species:
Mouse
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1 κ