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50-134-15

VEGF Receptor 3 Monoclonal Antibody (AFL4), eBioscience™, Invitrogen™

Manufacturer: Fischer Scientific

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Pack Size SKU Availability Price
Each of 1 50-134-15-Each-of-1 In Stock ₹ 16,855.32

50-134-15 - Each of 1

₹ 16,855.32

In Stock

Quantity

1

Base Price: ₹ 16,855.32

GST (18%): ₹ 3,033.958

Total Price: ₹ 19,889.278

Antigen

VEGF Receptor 3

Classification

Monoclonal

Concentration

0.5 mg/mL

Formulation

PBS with 0.09% sodium azide; pH 7.2

Gene Accession No.

P35917

Gene Symbols

FLT4

Purification Method

Affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

14257

Content And Storage

4° C

Form

Liquid

Applications

Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunoprecipitation, Neutralization, Western Blot

Clone

AFL4

Conjugate

Unconjugated

Gene

FLT4

Gene Alias

AI323512; Chy; chylous ascites; Flt4; FLT-4; FLT41; fms related tyrosine kinase 4; FMS-like tyrosine kinase 4; fms-related tyrosine kinase 4; LMPH1A; PCL; receptor protein tyrosine kinase; soluble VEGFR 3; sVEGFR 3; tyrosine-protein kinase receptor FLT4; Vascular endothelial growth factor receptor 3; vascular endothelial growth factor receptor-3; VEGF R3; VEGFR3; VEGFR-3

Host Species

Rat

Quantity

100 μg

Primary or Secondary

Primary

Target Species

Mouse

Product Type

Antibody

Isotype

IgG2a κ

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Description

  • Description: The AFL4 monoclonal antibody reacts with the mouse VEGF receptor-3, also known as Flt-4
  • This 195 kDa molecule was identified as an endothelial-specific member of the receptor tyrosine kinase (RTK) family
  • During early embryogenesis all endothelial cells express VEGFR-3, while in the adult tissues, VEGFR-3 expression disappears from the vascular endothelial cells and is observed only on the lymphatic endothelium
  • However, VEGFR-3 expression is induced in the adult tissue upon tumor implementation suggesting an important role for this receptor in the tumor angiogenesis
  • VEGF-C and VEGF-D bind to and activate VEGFR-3
  • AFL4 is an antagonist mAb
  • Applications Reported: The AFL4 antibody has been reported for use in flow cytometric analysis, immunoprecipitation, immunoblotting (WB), and immunohistochemical staining of frozen tissue sections
  • It has also been reported in blocking of ligand binding
  • (Please use Functional Grade purified AFL4, cat
  • 16-5988, in functional assays.)
  • Applications Tested: The AFL4 antibody has been tested by flow cytometric analysis of in vitro differentiated mouse endothelial cells
  • In brief, mouse ES cells were incubated on collagen IV matrix for 4 days and subsequently stimulated with VEGF under serum free conditions to induce further differentiation
  • It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest
  • Purity: Greater than 90%, as determined by SDS-PAGE
  • Vascular endothelial growth factor is a key regulator of blood vessel development in embryos and angiogenesis in adult tissues
  • Unlike VEGF, the related VEGFC stimulates the growth of lymphatic vessels through its specificl ymphatic endothelial receptor VEGFR-3
  • In 1998, Dumont showed that targeted inactivation of the VEGFR-3 gene in mice resulted in defective blood vessel development in early embryos
  • Vasculogenesis and angiogenesis occurred, but large vessels became abnormally organized with defective lumens, leading to fluid accumulation in the pericardial cavity and cardiovascular failure at embryonic day 9.5
  • Thus, VEGFR3 has an essential role in the development of theembryonic cardiovascular system before the emergence of the lymphatic vessels.

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Show Difference

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Fischer Scientific

50-134-15

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Antigen:
VEGF Receptor 3
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
P35917
Gene Symbols:
FLT4
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
14257
Content And Storage:
4° C
Form:
Liquid
Applications:
Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunoprecipitation, Neutralization, Western Blot
Clone:
AFL4
Conjugate:
Unconjugated
Gene:
FLT4
Gene Alias:
AI323512; Chy; chylous ascites; Flt4; FLT-4; FLT41; fms related tyrosine kinase 4; FMS-like tyrosine kinase 4; fms-related tyrosine kinase 4; LMPH1A; PCL; receptor protein tyrosine kinase; soluble VEGFR 3; sVEGFR 3; tyrosine-protein kinase receptor FLT4; Vascular endothelial growth factor receptor 3; vascular endothelial growth factor receptor-3; VEGF R3; VEGFR3; VEGFR-3
Host Species:
Rat
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Mouse
Product Type:
Antibody
Isotype:
IgG2a κ

Img

Fischer Scientific

50-134-16

--

Antigen:
VEGF Receptor 3
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
P35917
Gene Symbols:
FLT4
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
14257
Content And Storage:
4° C
Form:
Liquid
Applications:
Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunoprecipitation, Neutralization, Western Blot
Clone:
AFL4
Conjugate:
Unconjugated
Gene:
FLT4
Gene Alias:
AI323512; Chy; chylous ascites; Flt4; FLT-4; FLT41; fms related tyrosine kinase 4; FMS-like tyrosine kinase 4; fms-related tyrosine kinase 4; LMPH1A; PCL; receptor protein tyrosine kinase; soluble VEGFR 3; sVEGFR 3; tyrosine-protein kinase receptor FLT4; Vascular endothelial growth factor receptor 3; vascular endothelial growth factor receptor-3; VEGF R3; VEGFR3; VEGFR-3
Host Species:
Rat
Quantity:
500 μg
Primary or Secondary:
Primary
Target Species:
Mouse
Product Type:
Antibody
Isotype:
IgG2a κ

Img

Fischer Scientific

50-134-42

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Antigen:
MHC Class I (H-2Kd/H-2Dd)
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
P01895, P01896, P01897, P01899, P01900, P01901, P03991, P04223, P14426, P14427, P14428
Gene Symbols:
H2-D1, H2-K1
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
14964, 14972
Content And Storage:
4° C
Form:
Liquid
Applications:
Flow Cytometry
Clone:
34-1-2S
Conjugate:
Unconjugated
Gene:
H2-D1
Gene Alias:
class I major histocompatibility antigen H-2Kd; H-2 class I histocompatibility antigen, D-B alpha chain; H-2 class I histocompatibility antigen, K-B alpha chain; H-2 class I histocompatibility antigen, K-D alpha chain; H-2 class I histocompatibility antigen, K-K alpha chain; H-2 class I histocompatibility antigen, K-Q alpha chain; H-2 class I histocompatibility antigen, K-W28 alpha chain; H-2D; H2-D; H-2D cell surface glycoprotein; H-2D(B); H2-D1; H2-DC1-beta transplantation antigen protein; H2DD; H-2K; H2-K; H-2K(B); H-2K(d); H-2K(K); H-2K(Q); H2K1; H2-K1; H2KD; histocompatibility 2, D region locus 1; histocompatibility 2, K1, K region; K-f; MHC class I antigen; MHC class I H2 antigen; MHC class I H-2Dp; MHC class I H2-K-b-alpha-2 cell surface glycoprotein; MHC class I heavy chain H2-K; MHC H2-D-q alpha-chain; MHC H2-K transplantation antigen; Q5k protein
Host Species:
Mouse
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Mouse
Product Type:
Antibody
Isotype:
IgG2a κ

Img

Fischer Scientific

50-134-43

--

Antigen:
MHC Class I (H-2Kd/H-2Dd)
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
P01895, P01896, P01897, P01899, P01900, P01901, P03991, P04223, P14426, P14427, P14428
Gene Symbols:
H2-D1, H2-K1
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
14964, 14972
Content And Storage:
4° C
Form:
Liquid
Applications:
Flow Cytometry
Clone:
34-1-2S
Conjugate:
Unconjugated
Gene:
H2-K1
Gene Alias:
class I major histocompatibility antigen H-2Kd; H-2 class I histocompatibility antigen, D-B alpha chain; H-2 class I histocompatibility antigen, K-B alpha chain; H-2 class I histocompatibility antigen, K-D alpha chain; H-2 class I histocompatibility antigen, K-K alpha chain; H-2 class I histocompatibility antigen, K-Q alpha chain; H-2 class I histocompatibility antigen, K-W28 alpha chain; H-2D; H2-D; H-2D cell surface glycoprotein; H-2D(B); H2-D1; H2-DC1-beta transplantation antigen protein; H2DD; H-2K; H2-K; H-2K(B); H-2K(d); H-2K(K); H-2K(Q); H2K1; H2-K1; H2KD; histocompatibility 2, D region locus 1; histocompatibility 2, K1, K region; K-f; MHC class I antigen; MHC class I H2 antigen; MHC class I H-2Dp; MHC class I H2-K-b-alpha-2 cell surface glycoprotein; MHC class I heavy chain H2-K; MHC H2-D-q alpha-chain; MHC H2-K transplantation antigen; Q5k protein
Host Species:
Mouse
Quantity:
500 μg
Primary or Secondary:
Primary
Target Species:
Mouse
Product Type:
Antibody
Isotype:
IgG2a κ