50-136-28
IL-10 Monoclonal Antibody (JES5-16E3), eBioscience™, Invitrogen™
Manufacturer: Fischer Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-136-28-Each-of-1 | In Stock | ₹ 8,556.00 |
50-136-28 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 8,556.00
GST (18%): ₹ 1,540.08
Total Price: ₹ 10,096.08
Antigen
IL-10
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
P18893
Gene Symbols
IL10
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
16153
Content And Storage
4° C
Form
Liquid
Applications
Immunostaining
Clone
JES5-16E3
Conjugate
Unconjugated
Gene
IL10
Gene Alias
CSIF; cytokine; Cytokine synthesis inhibitory factor; GVHDS; H-IL-10; il 10; IL10; IL-10; IL-10 precursor; IL10A; IL10X; ILN; Interleukin; interleukin 10; Interleukin10; interleukin-10; MGC126450; MGC126451; RP11-262N9.1; T-cell growth inhibitory factor; TGIF
Host Species
Rat
Quantity
50 μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG2b κ
Description
- Description: The JES5-16E3 antibody reacts with mouse interleukin-10 (IL-10)
- Mouse IL-10 is an ∽18 kDa factor also known as Cytokine Synthesis Inhibitory Factor (CSIF)
- In the mouse, Th2 cells, B1 cells, macrophages, and keratinocytes are the major cell subsets that produce IL-10
- IL-10 inhibits synthesis of Th1 cytokines and proliferation of T cells, and acts as a costimulatory signal for mast cells, developing thymocytes and the Th2 response
- Applications Reported: The JES5-16E3 antibody has been reported for use in capture of mouse IL-10 by ELISA and ELISPOT, intracellular staining for flow cytometric analysis, IHC, and neutralization of IL-10 bioactivity
- Applications Tested: The JES5-16E3 antibody has been tested as the capture antibody in a sandwich ELISA for analysis of mouse Interleukin-10 (IL-10) in combination with the biotin JES5-2A5 (13-7102) antibody for detection and recombinant mouse IL-10 (14-8101) as the standard
- A suitable range of concentrations of this antibody for ELISA capture is 1-4 μg/mL
- A standard curve consisting of doubling dilutions of the recombinant standard over the range of 4000 pg/mL - 30 pg/mL should be included in each ELISA plate
- Purity: Greater than 90%, as determined by SDS-PAGE
- Aggregation: Less than 10%, as determined by HPLC
- Filtration: 0.2 μm post-manufacturing filtered
- IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes
- This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages
- It also enhances B cell survival, proliferation, and antibody production
- Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway
- Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract
- Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis
- Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.
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Antigen: IL-10
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.: P18893
Gene Symbols: IL10
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 16153
Content And Storage: 4° C
Form: Liquid
Applications: Immunostaining
Clone: JES5-16E3
Conjugate: Unconjugated
Gene: IL10
Gene Alias: CSIF; cytokine; Cytokine synthesis inhibitory factor; GVHDS; H-IL-10; il 10; IL10; IL-10; IL-10 precursor; IL10A; IL10X; ILN; Interleukin; interleukin 10; Interleukin10; interleukin-10; MGC126450; MGC126451; RP11-262N9.1; T-cell growth inhibitory factor; TGIF
Host Species: Rat
Quantity: 50 μg
Primary or Secondary: Primary
Target Species: Mouse
Product Type: Antibody
Isotype: IgG2b κ
Antigen:
IL-10
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
P18893
Gene Symbols:
IL10
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
16153
Content And Storage:
4° C
Form:
Liquid
Applications:
Immunostaining
Clone:
JES5-16E3
Conjugate:
Unconjugated
Gene:
IL10
Gene Alias:
CSIF; cytokine; Cytokine synthesis inhibitory factor; GVHDS; H-IL-10; il 10; IL10; IL-10; IL-10 precursor; IL10A; IL10X; ILN; Interleukin; interleukin 10; Interleukin10; interleukin-10; MGC126450; MGC126451; RP11-262N9.1; T-cell growth inhibitory factor; TGIF
Host Species:
Rat
Quantity:
50 μg
Primary or Secondary:
Primary
Target Species:
Mouse
Product Type:
Antibody
Isotype:
IgG2b κ
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