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50-136-96

TNF alpha Polyclonal Antibody, eBioscience™, Invitrogen™

Manufacturer: Invitrogen

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Each of 1 50-136-96-Each-of-1 In Stock ₹ 24,897.96

50-136-96 - Each of 1

₹ 24,897.96

In Stock

Quantity

1

Base Price: ₹ 24,897.96

GST (18%): ₹ 4,481.633

Total Price: ₹ 29,379.593

Antigen

TNF alpha

Classification

Polyclonal

Conjugate

Unconjugated

Gene

Tnf

Gene Alias

APC1 protein; Cachectin; C-domain 1; C-domain 2; cTNF; DADB-70P7.1; DIF; ICD1; ICD2; Intracellular domain 1; Intracellular domain 2; N-terminal fragment; NTF; RATTNF; Tnf; TNF alpha; TNF superfamily; TNF a; TNF, macrophage-derived; TNF, monocyte-derived; TNFA; TNF-a; TNFalpha; TNF-alpha; Tnfsf1a; TNFSF2; TNFa; TNLG1F; Tumor necrosis factor; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor alpha (cachetin); tumor necrosis factor alpha precursor; tumor necrosis factor ligand 1F; tumor necrosis factor ligand superfamily member 2; Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form; tumor necrosis factor-alpha; tumor necrosis factor-alpha precursor; tumor-necrosis factor; tumour necrosis factor

Host Species

Rabbit

Quantity

500 μg

Primary or Secondary

Primary

Target Species

Mouse, Rat

Product Type

Antibody

Isotype

IgG

Applications

Functional Assay

Concentration

0.5 mg/mL

Formulation

PBS with 0.09% sodium azide; pH 7.2

Gene Accession No.

P06804, P16599

Gene Symbols

Tnf

Purification Method

Affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

21926, 24835

Content And Storage

4° C

Form

Liquid

Description

  • Description: The affinity purified polyclonal rabbit antibody reacts with mouse and rat tumor necrosis factor-alpha
  • Mouse TNF alpha is a 17 kDa factor produced by macrophages, monocytes, neutrophils, CD4 T cells, and NK cells
  • A 26 kDa form is expressed as a membrane-bound molecule
  • TNF alpha is cytolytic and plays an important role in immune regulation
  • Bioactive TNF alpha exists as a homotrimer
  • Applications Reported: This affinity purified anti-mouse/rat TNF alpha antibody has been reported for use as the plate-coating (ELISA Capture) antibody for the In Vivo Cytokine Capture Assay (IVCCA), in conjunction with the Functional Grade Biotinylated TN3.19 antibody for In Vivo Capture (ELISA Detection)
  • The IVCCA facilitates measurement of cytokines in serum by increasing their in vivo half lives dramatically
  • This increases the sensitivity of measurement of in vivo cytokine production 30- to 1000- fold
  • For detailed methodology in this application, please refer to this reference: Finkelman, F., S
  • Morris, T
  • Orekhova, and D
  • Sehy
  • 2003
  • The In Vivo Cytokine Capture Assay for measurement of cytokine production in the mouse
  • In Current Protocols in Immunology
  • Unit 6.28
  • J
  • Coligan, A
  • Kruisbeek, D
  • Margulies, E
  • Shevach, and W
  • Strober, eds
  • John Wiley and Sons, New York.
  • TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily
  • This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR
  • TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation
  • TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions
  • Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice
  • Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors
  • TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity
  • This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.

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Invitrogen

50-136-96

--

Antigen:
TNF alpha
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Tnf
Gene Alias:
APC1 protein; Cachectin; C-domain 1; C-domain 2; cTNF; DADB-70P7.1; DIF; ICD1; ICD2; Intracellular domain 1; Intracellular domain 2; N-terminal fragment; NTF; RATTNF; Tnf; TNF alpha; TNF superfamily; TNF a; TNF, macrophage-derived; TNF, monocyte-derived; TNFA; TNF-a; TNFalpha; TNF-alpha; Tnfsf1a; TNFSF2; TNFa; TNLG1F; Tumor necrosis factor; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor alpha (cachetin); tumor necrosis factor alpha precursor; tumor necrosis factor ligand 1F; tumor necrosis factor ligand superfamily member 2; Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form; tumor necrosis factor-alpha; tumor necrosis factor-alpha precursor; tumor-necrosis factor; tumour necrosis factor
Host Species:
Rabbit
Quantity:
500 μg
Primary or Secondary:
Primary
Target Species:
Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Functional Assay
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
P06804, P16599
Gene Symbols:
Tnf
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
21926, 24835
Content And Storage:
4° C
Form:
Liquid

Img

Fischer Scientific

50-136-99

--

Antigen:
TNF alpha
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene:
Tnf
Gene Alias:
APC1 protein; Cachectin; C-domain 1; C-domain 2; cTNF; DADB-70P7.1; DIF; ICD1; ICD2; Intracellular domain 1; Intracellular domain 2; N-terminal fragment; NTF; RATTNF; Tnf; TNF alpha; TNF superfamily; TNF a; TNF, macrophage-derived; TNF, monocyte-derived; TNFA; TNF-a; TNFalpha; TNF-alpha; Tnfsf1a; TNFSF2; TNFa; TNLG1F; Tumor necrosis factor; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor alpha (cachetin); tumor necrosis factor alpha precursor; tumor necrosis factor ligand 1F; tumor necrosis factor ligand superfamily member 2; Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form; tumor necrosis factor-alpha; tumor necrosis factor-alpha precursor; tumor-necrosis factor; tumour necrosis factor
Host Species:
Mouse
Quantity:
50 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1 κ
Applications:
Flow Cytometry
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
P01375
Gene Symbols:
Tnf
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
7124
Content And Storage:
4° C
Form:
Liquid

Img

Fischer Scientific

50-137-00

--

Antigen:
TNF alpha
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene:
Tnf
Gene Alias:
APC1 protein; Cachectin; C-domain 1; C-domain 2; cTNF; DADB-70P7.1; DIF; ICD1; ICD2; Intracellular domain 1; Intracellular domain 2; N-terminal fragment; NTF; RATTNF; Tnf; TNF alpha; TNF superfamily; TNF a; TNF, macrophage-derived; TNF, monocyte-derived; TNFA; TNF-a; TNFalpha; TNF-alpha; Tnfsf1a; TNFSF2; TNFa; TNLG1F; Tumor necrosis factor; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor alpha (cachetin); tumor necrosis factor alpha precursor; tumor necrosis factor ligand 1F; tumor necrosis factor ligand superfamily member 2; Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form; tumor necrosis factor-alpha; tumor necrosis factor-alpha precursor; tumor-necrosis factor; tumour necrosis factor
Host Species:
Mouse
Quantity:
500 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1 κ
Applications:
Flow Cytometry
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
P01375
Gene Symbols:
Tnf
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
7124
Content And Storage:
4° C
Form:
Liquid

Img

Fischer Scientific

50-137-01

--

Antigen:
TNF alpha
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene:
Tnf
Gene Alias:
APC1 protein; Cachectin; C-domain 1; C-domain 2; cTNF; DADB-70P7.1; DIF; ICD1; ICD2; Intracellular domain 1; Intracellular domain 2; N-terminal fragment; NTF; RATTNF; Tnf; TNF alpha; TNF superfamily; TNF a; TNF, macrophage-derived; TNF, monocyte-derived; TNFA; TNF-a; TNFalpha; TNF-alpha; Tnfsf1a; TNFSF2; TNFa; TNLG1F; Tumor necrosis factor; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor alpha (cachetin); tumor necrosis factor alpha precursor; tumor necrosis factor ligand 1F; tumor necrosis factor ligand superfamily member 2; Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form; tumor necrosis factor-alpha; tumor necrosis factor-alpha precursor; tumor-necrosis factor; tumour necrosis factor
Host Species:
Armenian Hamster
Quantity:
50 μg
Primary or Secondary:
Primary
Target Species:
Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
ELISA, Flow Cytometry, Functional Assay, Neutralization
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
P06804, P16599
Gene Symbols:
Tnf
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
21926, 24835
Content And Storage:
4° C
Form:
Liquid