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50-142-91

SIGLEC H Monoclonal Antibody (eBio440c), Functional Grade, eBioscience™, Invitrogen™

Manufacturer: Invitrogen

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Pack Size	SKU	Availability	Price
Each	50-142-91-Each	In Stock	₹ 10,151.69

50-142-91 - Each

₹ 10,151.69

In Stock

Quantity

Base Price: ₹ 10,151.69

GST (18%): ₹ 1,827.304

Total Price: ₹ 11,978.994

Antigen

SIGLEC H

Classification

Monoclonal

Concentration

1 mg/mL

Formulation

PBS with no preservative; pH 7.2

Gene Accession No.

Gene Symbols

Siglech

Purification Method

Affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

233274

Content And Storage

4° C

Form

Liquid

Applications

Flow Cytometry, Functional Assay

Clone

eBio440c

Conjugate

Functional Grade

Gene

Siglech

Gene Alias

6430529G09Rik; sialic acid binding Ig-like lectin H; Siglec; Siglech; Siglec-H; SIGLEC-like protein

Host Species

Rat

Quantity

100 μg

Primary or Secondary

Primary

Target Species

Mouse

Product Type

Antibody

Isotype

IgG2b κ

Description

Description: The monoclonal antibody eBio440c recognizes Siglec-H, a protein exclusively found on pDC (plasmacytoid dendritic cells) or type I IFN-producing cells (IPC) in the naive mouse
Mouse IPC are typically PDCA+, CD11c+, CD11b-, B220+, and Ly-6C+, and are quick to respond to viruses
Siglec-H is a transmembrane protein of the Ig superfamily that like CD33 have been shown to bind sialic acid but lacks the characteristic cytoplasmic ITIM domain (immunoreceptor tyrosine based inhibitory motif)
To overcome the lack of a cytoplasmic domain, Siglec-H associates with DAP12 thereby allowing for signal transduction
The eBio440c antibody has been shown to inhibit pDC function (inhbits IFNalpha secretion in response to CpG)
It has been observed that some mouse strains (such as SJL) have higher percentages of pDCs compared to C57BL/6
Applications Reported: This eBio440c antibody has been reported for use in flow cytometric analysis
Applications Tested: This eBio440c antibody has been tested by blocking staining of the direct conjugate of eBio440c
This can be used at less than or equal to 2.0 μg per test
A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest
Siglec-H, a protein exclusively found on pDC (plasmacytoid dendritic cells) or type I IFN-producing cells (IPC) in the naive mouse
Mouse IPC are typically PDCA+, CD11c+, CD11b-, B220+, and Ly-6C+, and are quick to respond to viruses
Siglec-H is a transmembrane protein of the Ig superfamily that like CD33 have been shown to bind sialic acid but lacks the characteristic cytoplasmic ITIM domain (immunoreceptor tyrosine based inhibitory motif)
To overcome the lack of a cytoplasmic domain, Siglec-H associates with DAP12 thereby allowing for signal transduction
The eBio440c antibody has been shown to inhibit pDC function (inhbits IFNalpha secretion in response to CpG)
It has been observed that some mouse strains (such as SJL) have higher percentages of pDCs compared to C57BL/6.

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Invitrogen

50-142-91

Antigen:

SIGLEC H

Classification:

Monoclonal

Concentration:

1 mg/mL

Formulation:

PBS with no preservative; pH 7.2

Gene Accession No.:

0

Gene Symbols:

Siglech

Purification Method:

Affinity chromatography

Regulatory Status:

RUO

Gene ID (Entrez):

233274

Content And Storage:

4° C

Form:

Liquid

Applications:

Flow Cytometry, Functional Assay

Clone:

eBio440c

Conjugate:

Functional Grade

Gene:

Siglech

Gene Alias:

6430529G09Rik; sialic acid binding Ig-like lectin H; Siglec; Siglech; Siglec-H; SIGLEC-like protein

Host Species:

Rat

Quantity:

100 μg

Primary or Secondary:

Primary

Target Species:

Mouse

Product Type:

Antibody

Isotype:

IgG2b κ

XenoTech,LLC

50-142-926

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XenoTech,LLC

50-142-927

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XenoTech,LLC

50-142-929

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SIGLEC H Monoclonal Antibody (eBio440c), Functional Grade, eBioscience™, Invitrogen™

Select a Size

Select a Size

Properties

Antigen

Classification

Concentration

Formulation

Gene Accession No.

Gene Symbols

Purification Method

Regulatory Status

Gene ID (Entrez)

Content And Storage

Form

Applications

Clone

Conjugate

Gene

Gene Alias

Host Species

Quantity

Primary or Secondary

Target Species

Product Type

Isotype

Description

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Invitrogen

XenoTech,LLC

XenoTech,LLC

XenoTech,LLC