CD197 (CCR7) Monoclonal Antibody (4B12), Functional Grade, eBioscience™, Invitrogen™

Description

• Description: The 4B12 monoclonal antibody reacts with mouse CCR7, also known as EBI-1 and CD197
• CCR7 is a chemokine receptor for the chemokines CCL19 (CKβ11, ELC, MIP3β, Scya19, Exodus-3) and CCL21 (CKβ9, SLC, MIP2β, Scya21, Exodus-2)
• In recent years, the role of chemokines in directing the migration of lymphocytes has been well-characterized
• One of the most important mediators of homeostatic trafficking of naive T cells to secondary lymphoid organs (SLO) is the chemokine receptor CCR7
• Binding of its ligands, CCL19 and CCL21, mediates the trans endothelial migration of T cells across high endothelial venules into SLO
• It has also been demonstrated that CCR7 plays a role in the localization of dendritic cells and B cells during an immune response
• CCR7 is a chemokine receptor for the chemokines CCL19 (CKβ11, ELC, MIP3β, Scya19, Exodus-3) and CCL21 (CKβ9, SLC, MIP2β, Scya21, Exodus-2)
• In addition to its significant role in the chemotaxis of lymphocytes, human CCR7 has also been recognized as a marker for a distinct subset of memory T cells, the central memory (TCM) population
• These cells are characterized by the expression of CCR7 and CD62L and reside within peripheral lymphoid organs
• CCR7 also plays a role in thymocyte development and its deficiency leads to disturbed thymic architecture, aberrant T cell development, and limited thymocyte expansion
• CCR7 is a member of the G protein coupled receptor family, which is a subfamily of chemokines
• CCR7 was identified to be induced by the Epstein Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes
• CCR7 has been reported to be expressed in blood, bone marrow, lymph node, and intestine
• CCR7 is particularly expressed in lymphoid tissues and in activated B and T lymphocytes and has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation
• The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor
• ESTs have been isolated from blood, embryo, lymph node, and thymus libraries
• Receptors for the C - C chemokine family include CCR 1, CCR 2A, CCR 3, CCR 4, CCR 5 and the Duffy blood group antigen
• The C-C receptors are important in the function of T cell chemotaxis and migration of phagocytic cells to sites of inflammation.