50-147-86
LAP (Latency Associated peptide) Monoclonal Antibody (VB3A9), Functional Grade, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-147-86-Each-of-1 | In Stock | ₹ 18,566.52 |
50-147-86 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 18,566.52
GST (18%): ₹ 3,341.974
Total Price: ₹ 21,908.494
Antigen
LAP (Latency Associated peptide)
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with no preservative; pH 7.2
Gene Accession No.
P01137
Gene Symbols
TGFB1
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
7040
Content And Storage
4° C
Form
Liquid
Applications
Immunoprecipitation, Western Blot
Clone
VB3A9
Conjugate
Functional Grade
Gene
TGFB1
Gene Alias
CED; DPD1; LAP; latency-associated peptide; prepro-transforming growth factor beta-1; regulatory protein; TGFB; Tgfb1; Tgfb-1; TGFbeta; TGF-beta 1; TGFbeta1; TGF-beta1; TGF-beta-1; transforming growth factor beta 1; transforming growth factor beta-1; Transforming growth factor beta-1 proprotein; transforming growth factor, beta 1; transforming growth factor-beta 1
Host Species
Mouse
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Related Products
Description
- Description: This VB3A9 monoclonal antibody recognizes human latency-associated peptide (LAP), also known as the TGF-beta propeptide
- Human LAP is a homodimer of 65-75 kDa that is non-covalently associated with TGF-beta and this complex is also referred to as the small latent complex (SLC)
- LAP can be covalently associated with latent TGF-beta binding proteins (LTBP) through disulfide bonds, forming the large latent complex (LLC)
- The association of LAP with TGF-beta facilitates its secretion and also renders TGF-beta inactive
- VB3A9 has been reported to cross-react with non-human primate LAP, but does not cross-react with mouse LAP
- Applications Reported: This VB3A9 antibody has been reported for use in immunoblotting (WB) and immunoprecipitation
- Applications Tested: This VB3A9 antibody has been tested by immunoblot analysis of human platelets under reducing conditions at 5 μg/mL
- It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest
- Storage and handling: Use in a sterile environment
- Filtration: 0.2 μm post-manufacturing filtered
- Purity: Greater than 90%, as determined by SDS-PAGE
- Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by LAL assay
- Aggregation: Less than 10%, as determined by HPLC
- TGF beta-1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines, found almost ubiquitously in tissues
- Transforming growth factor (TGF)-b is stored in the extracellular matrix as a latent complex with its prodomain
- Activation of TGF-b1 requires the binding of aV integrin to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-b binding proteins
- Latent forms are complexes of TGF-beta, an aminoterminal portion of the TGF-beta precursor, designated TGF-LAP (TGF-latency associated peptide), and a specific binding protein, known as LTBP.
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Antigen: LAP (Latency Associated peptide)
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with no preservative; pH 7.2
Gene Accession No.: P01137
Gene Symbols: TGFB1
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 7040
Content And Storage: 4° C
Form: Liquid
Applications: Immunoprecipitation, Western Blot
Clone: VB3A9
Conjugate: Functional Grade
Gene: TGFB1
Gene Alias: CED; DPD1; LAP; latency-associated peptide; prepro-transforming growth factor beta-1; regulatory protein; TGFB; Tgfb1; Tgfb-1; TGFbeta; TGF-beta 1; TGFbeta1; TGF-beta1; TGF-beta-1; transforming growth factor beta 1; transforming growth factor beta-1; Transforming growth factor beta-1 proprotein; transforming growth factor, beta 1; transforming growth factor-beta 1
Host Species: Mouse
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Antigen:
LAP (Latency Associated peptide)
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with no preservative; pH 7.2
Gene Accession No.:
P01137
Gene Symbols:
TGFB1
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
7040
Content And Storage:
4° C
Form:
Liquid
Applications:
Immunoprecipitation, Western Blot
Clone:
VB3A9
Conjugate:
Functional Grade
Gene:
TGFB1
Gene Alias:
CED; DPD1; LAP; latency-associated peptide; prepro-transforming growth factor beta-1; regulatory protein; TGFB; Tgfb1; Tgfb-1; TGFbeta; TGF-beta 1; TGFbeta1; TGF-beta1; TGF-beta-1; transforming growth factor beta 1; transforming growth factor beta-1; Transforming growth factor beta-1 proprotein; transforming growth factor, beta 1; transforming growth factor-beta 1
Host Species:
Mouse
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
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