50-151-06

CD161 Monoclonal Antibody (HP-3G10), APC, eBioscience™, Invitrogen™

Manufacturer: Invitrogen

Select a Size

Pack Size SKU Availability Price
Each of 1 50-151-06-Each-of-1 In Stock ₹ 31,657.20

50-151-06 - Each of 1

₹ 31,657.20

In Stock

Quantity

1

Base Price: ₹ 31,657.20

GST (18%): ₹ 5,698.296

Total Price: ₹ 37,355.496

Antigen

CD161

Classification

Monoclonal

Concentration

5 μL/Test

Formulation

PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2

Gene Accession No.

Q12918

Gene Symbols

Klrb1

Purification Method

Affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

3820

Content And Storage

4° C, store in dark, DO NOT FREEZE!

Form

Liquid

Applications

Flow Cytometry

Clone

HP-3G10

Conjugate

APC

Gene

Klrb1

Gene Alias

4930431A04Rik; Antigen 3.2.3; CD161; CD161 antigen-like family member A; CD161 antigen-like family member B; CD161a; CD161b; CLEC5B; C-type lectin domain family 5 member B; EMBL:AAQ11375.1}; Gm4696; HNKR-P1a; Immunoreceptor NKR-P1E; immunoreceptor NKR-P1G; inhibitory receptor NKR-P1B; killer cell lectin like receptor B1; killer cell lectin-like receptor subfamily A member 1 complex; killer cell lectin-like receptor subfamily B member 1; killer cell lectin-like receptor subfamily B member 1 complex; killer cell lectin-like receptor subfamily B member 1A; killer cell lectin-like receptor subfamily B member 1B; killer cell lectin-like receptor subfamily B member 1B allele A; Killer cell lectin-like receptor subfamily B member 1B allele B; killer cell lectin-like receptor subfamily B member 1B allele C; killer cell lectin-like receptor subfamily B member 1D; killer cell lectin-like receptor subfamily B member 1F; killer cell lectin-like receptor subfamily B member 1G; killer cell lectin-like receptor subfamily B, member 1; killer cell lectin-like receptor subfamily B, member 1A; Klrb1; Klrb1a; Klrb1b; klrb1b {ECO:0000312; Klrb1d; Klrb1f; Klrb1g; Klrb6; lectin-like transmembrane protein Nkrp1g; Ly55; Ly-55; Ly55a; ly-55A; Ly55b; ly-55b; Ly55d; ly-55d; lymphocyte antigen 55; lymphocyte antigen 55 complex, locus A; lymphocyte antigen 55 complex, locus B; lymphocyte antigen 55 complex, locus D; lymphocyte antigen 55A; lymphocyte antigen 55b; lymphocyte antigen 55d; MGC138614; natural killer cell receptor; natural killer cell receptor protein NKR-P1A; natural killer cell receptor protein NKR-P1B; natural killer cell receptor-P1; natural killer cell surface protein NKR-P1B allele B6; Natural killer cell surface protein NKR-P1B allele RNK/SD/BN/F344; natural killer cell surface protein NKR-P1B allele SJL/BALB; natural killer cell surface protein NKR-P1B allele TO; natural killer cell surface protein NKR-P1G; Natural killer cell surface protein P1-2; natural killer cell surface protein P1-3.2.3; Natural killer cell surface protein P1A; natural killer lectin-like receptor 1E; natural killer lectin-like receptor protein 1 e; NKR; NKR-P1; NKR-P1 2; NKR-P1 3.2.3; NKR-P1 34; NKR-P1.7; NKRP12; NKRP1A; NKR-P1A; Nkrp1-a; Nkrp1b; Nkr-p1b; Nkrp1-b; Nkrp1d; NKR-P1D; Nkrp1e; Nkr-p1e; Nkrp-1e; Nkrp1g; NKR-P1G; RGD:2975}

Host Species

Mouse

Quantity

100 Tests

Primary or Secondary

Primary

Target Species

Human

Product Type

Antibody

Isotype

IgG1 κ

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Description

  • Description: This HP-3G10 monoclonal antibody reacts with CD161 (also known as NKR-P1A), a member of the C-type lectin superfamily
  • The human homologue of NK1.1 in C57BL/6 mice, CD161 is expressed on natural killer cells and is upregulated in response to IL-12
  • CD161 can also be detected on various T cell subsets, including memory/effector CD4+ T cells, CD8+ T cells, gamma delta TCR T cells, and a subset of CD3+ thymocytes
  • Finally, CD161 expression has been demonstrated on human Th17 CD4+ T cells
  • The function of this receptor is unclear although studies suggest a possible stimulatory role
  • Nevertheless, Lectin-like transcript-1 (LLT1), which is also known as osteoclast inhibitory lectin, has been identified as the ligand for CD161
  • Applications Reported: This HP-3G10 antibody has been reported for use in flow cytometric analysis
  • Applications Tested: This HP-3G10 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells
  • This can be used at 5 μL (0.25 μg) per test
  • A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
  • Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
  • Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser
  • Filtration: 0.2 μm post-manufacturing filtered
  • KLRB1 (Killer cell lectin like receptor subfamily B, member 1, CD-161) protein is classified as a type II membrane protein because it has an external C terminus
  • KLRB1 cell surface antigen is expressed by almost all NK cells and in a small subset of CD3+ve T cells
  • KLRB1 is a homodimeric cell surface protein, comprising two chains with molecular weights ranging from 40-44kDa
  • KLRB1 plays an inhibitory role on natural killer (NK) cells
  • Activation of KLRB1 leads to acid sphingomyelnase/SMPD1 stimulation and an increase in intracellular ceramide
  • Moreover, there is also an activation of AKT1/PKB and RPS6KA1/RSK1 kinase stimulation, and T cell proliferation by anti-CD3
  • KLRB1 acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope and to the N-acetyllactosamine epitope
  • KLRB1 also binds to CLEC2D/LLT1 as a ligand, and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells
  • The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain.

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Invitrogen

50-151-06

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Antigen:
CD161

Classification:
Monoclonal

Concentration:
5 μL/Test

Formulation:
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2

Gene Accession No.:
Q12918

Gene Symbols:
Klrb1

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
3820

Content And Storage:
4° C, store in dark, DO NOT FREEZE!

Form:
Liquid

Applications:
Flow Cytometry

Clone:
HP-3G10

Conjugate:
APC

Gene:
Klrb1

Gene Alias:
4930431A04Rik; Antigen 3.2.3; CD161; CD161 antigen-like family member A; CD161 antigen-like family member B; CD161a; CD161b; CLEC5B; C-type lectin domain family 5 member B; EMBL:AAQ11375.1}; Gm4696; HNKR-P1a; Immunoreceptor NKR-P1E; immunoreceptor NKR-P1G; inhibitory receptor NKR-P1B; killer cell lectin like receptor B1; killer cell lectin-like receptor subfamily A member 1 complex; killer cell lectin-like receptor subfamily B member 1; killer cell lectin-like receptor subfamily B member 1 complex; killer cell lectin-like receptor subfamily B member 1A; killer cell lectin-like receptor subfamily B member 1B; killer cell lectin-like receptor subfamily B member 1B allele A; Killer cell lectin-like receptor subfamily B member 1B allele B; killer cell lectin-like receptor subfamily B member 1B allele C; killer cell lectin-like receptor subfamily B member 1D; killer cell lectin-like receptor subfamily B member 1F; killer cell lectin-like receptor subfamily B member 1G; killer cell lectin-like receptor subfamily B, member 1; killer cell lectin-like receptor subfamily B, member 1A; Klrb1; Klrb1a; Klrb1b; klrb1b {ECO:0000312; Klrb1d; Klrb1f; Klrb1g; Klrb6; lectin-like transmembrane protein Nkrp1g; Ly55; Ly-55; Ly55a; ly-55A; Ly55b; ly-55b; Ly55d; ly-55d; lymphocyte antigen 55; lymphocyte antigen 55 complex, locus A; lymphocyte antigen 55 complex, locus B; lymphocyte antigen 55 complex, locus D; lymphocyte antigen 55A; lymphocyte antigen 55b; lymphocyte antigen 55d; MGC138614; natural killer cell receptor; natural killer cell receptor protein NKR-P1A; natural killer cell receptor protein NKR-P1B; natural killer cell receptor-P1; natural killer cell surface protein NKR-P1B allele B6; Natural killer cell surface protein NKR-P1B allele RNK/SD/BN/F344; natural killer cell surface protein NKR-P1B allele SJL/BALB; natural killer cell surface protein NKR-P1B allele TO; natural killer cell surface protein NKR-P1G; Natural killer cell surface protein P1-2; natural killer cell surface protein P1-3.2.3; Natural killer cell surface protein P1A; natural killer lectin-like receptor 1E; natural killer lectin-like receptor protein 1 e; NKR; NKR-P1; NKR-P1 2; NKR-P1 3.2.3; NKR-P1 34; NKR-P1.7; NKRP12; NKRP1A; NKR-P1A; Nkrp1-a; Nkrp1b; Nkr-p1b; Nkrp1-b; Nkrp1d; NKR-P1D; Nkrp1e; Nkr-p1e; Nkrp-1e; Nkrp1g; NKR-P1G; RGD:2975}

Host Species:
Mouse

Quantity:
100 Tests

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG1 κ

Img

Fischer Scientific

50-151-07

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Antigen:
CD162 (PSGL-1)

Classification:
Monoclonal

Concentration:
5 μL/Test

Formulation:
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2

Gene Accession No.:
Q14242

Gene Symbols:
SELPLG

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
6404

Content And Storage:
4° C, store in dark, DO NOT FREEZE!

Form:
Liquid

Applications:
Flow Cytometry

Clone:
FLEG

Conjugate:
APC

Gene:
SELPLG

Gene Alias:
CD162; CLA; Cutaneous lymphocyte associated antigen; cutaneous lymphocyte-associated associated antigen; leukocyte cell surface adhesion molecule; P-selectin glycoprotein ligand 1; P-selectin glycoprotein ligand 1 propeptide; P-selectin glycoprotein ligand-1; Psgl1; Psgl-1; Selectin P ligand; selectin, platelet (p-selectin) ligand; Selp1; SELPG; Selpl; SELPLG

Host Species:
Mouse

Quantity:
25 Tests

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG2a κ

Img

Biotang Inc

50-151-074

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Biotang Inc

50-151-075

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