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50-155-8060

Chk2 Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Manufacturer: Bethyl Laboratories, Inc

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Pack Size SKU Availability Price
Each of 1 50-155-8060-Each-of-1 In Stock ₹ 41,863.65

50-155-8060 - Each of 1

₹ 41,863.65

In Stock

Quantity

1

Base Price: ₹ 41,863.65

GST (18%): ₹ 7,535.457

Total Price: ₹ 49,399.107

Antigen

Chk2

Classification

Polyclonal

Conjugate

Unconjugated

Gene

CHEK2

Gene Alias

RP11-436C9.1, CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53

Host Species

Rabbit

Purification Method

Antigen affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

11200

Content And Storage

4° C

Form

Liquid

Applications

Immunohistochemistry, Immunoprecipitation

Concentration

1 mg/ml

Formulation

phosphate, tris citrate with 0.09% sodium azide; pH 7-8

Gene Accession No.

O96017

Gene Symbols

CHEK2

Immunogen

Between 475 and 525

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human

Product Type

Antibody

Isotype

IgG

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Description

  • The recommended shelf life for this product is 1 year from date of receipt
  • Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections
  • Checkpoint kinase 2 (Chk2) is a serine/threonine-protein kinase which functions as a cell cycle checkpoint regulator
  • ATM and ATR kinases are activated in response to ionizing and ultraviolet radition, and phosphorylate Thr68 and other sites in the amino-terminal region of Chk2 dimerisation and activation
  • Activated Chk2 phosphorylates and inhibits Cdc25C phosphates, preventing the entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1
  • In addition, Chk2 can phosphorylate BRCA1, allowing BRCA1 to restore survival after DNA damage
  • Chk2 is a putative tumor suppressor protein, with mutations in to the Chk2 gene linked to Li-Fraumeni syndrome, a familiar cancer usually associated with inherited mutations in TP53
  • Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors.

Compare Similar Items

Show Difference

Img

Bethyl Laboratories, Inc

50-155-8060

--

Antigen:
Chk2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
CHEK2
Gene Alias:
RP11-436C9.1, CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
11200
Content And Storage:
4° C
Form:
Liquid
Applications:
Immunohistochemistry, Immunoprecipitation
Concentration:
1 mg/ml
Formulation:
phosphate, tris citrate with 0.09% sodium azide; pH 7-8
Gene Accession No.:
O96017
Gene Symbols:
CHEK2
Immunogen:
Between 475 and 525
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG

Img

Bethyl Laboratories, Inc

50-155-8061

--

Antigen:
Chk2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
CHEK2
Gene Alias:
RP11-436C9.1, CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
11200
Content And Storage:
4° C
Form:
Liquid
Applications:
Immunohistochemistry, Immunoprecipitation
Concentration:
1 mg/ml
Formulation:
phosphate, tris citrate with 0.09% sodium azide; pH 7-8
Gene Accession No.:
O96017
Gene Symbols:
CHEK2
Immunogen:
Between 475 and 525
Quantity:
10 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG

Img

Bethyl Laboratories, Inc

50-155-8065

--

Antigen:
ErbB2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
ERBB2
Gene Alias:
Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein, MLN 19, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2, CD340, MLN19, NEU, NGL, c-erb B2/neu protein, herstatin, metas
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
2064
Content And Storage:
4° C
Form:
Liquid
Applications:
Immunohistochemistry, Immunoprecipitation, Western Blot
Concentration:
0.2 mg/ml
Formulation:
TBS with 0.1% BSA and 0.09% sodium azide
Gene Accession No.:
P04626
Gene Symbols:
ERBB2
Immunogen:
Between 975 and 1025
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG

Img

Bethyl Laboratories, Inc

50-155-8067

--

Antigen:
ErbB2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
ERBB2
Gene Alias:
Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein, MLN 19, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2, CD340, MLN19, NEU, NGL, c-erb B2/neu protein, herstatin, metas
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
2064
Content And Storage:
4° C
Form:
Liquid
Applications:
Immunohistochemistry, Immunoprecipitation, Western Blot
Concentration:
0.2 mg/ml
Formulation:
TBS with 0.1% BSA and 0.09% sodium azide
Gene Accession No.:
P04626
Gene Symbols:
ERBB2
Immunogen:
Between 1200 and C-term
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG