SAFB1 Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Description

• The recommended shelf life for this product is 1 year from date of receipt
• Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections
• Based on 100% sequence identity, this antibody is predicted to react with Orangutan This gene encodes a DNA-binding protein that has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA)
• This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein
• Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR
• This encoded protein is thought to serve as a molecular base to assemble a ′transcriptosome complex′ in the vicinity of actively transcribed genes
• It is involved in the regulation of the heat shock protein 27 transcription and also can act as an estrogen receptor corepressor
• This gene is a candidate gene for breast tumorigenesis.