50-155-9264

Senataxin Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Manufacturer: Bethyl Laboratories, Inc

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Pack Size SKU Availability Price
Each of 1 50-155-9264-Each-of-1 In Stock ₹ 41,863.65

50-155-9264 - Each of 1

₹ 41,863.65

In Stock

Quantity

1

Base Price: ₹ 41,863.65

GST (18%): ₹ 7,535.457

Total Price: ₹ 49,399.107

Antigen

Senataxin

Classification

Polyclonal

Conjugate

Unconjugated

Gene

SETX

Gene Alias

ALS4, amyotrophic lateral sclerosis 4, amyotrophic lateral sclerosis 4 protein, AOA2, bA479K20.2, KIAA0625, SCAR1, SEN1 homolog, Senataxin, spinocerebellar ataxia, recessive, non-Friedreich type 1

Host Species

Rabbit

Purification Method

Antigen affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

23064

Content And Storage

4° C

Form

Liquid

Applications

Immunoprecipitation, Western Blot

Concentration

1 mg/ml

Formulation

phosphate, tris citrate with 0.09% sodium azide; pH 7-8

Gene Accession No.

Q7Z333

Gene Symbols

SETX

Immunogen

Between 875 and 925

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human

Product Type

Antibody

Isotype

IgG

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Description

  • The recommended shelf life for this product is 1 year from date of receipt
  • Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity
  • Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224)
  • Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850)
  • Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224, PubMed:26700805)
  • Required for the 3′ transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation
  • Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789)
  • In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744)
  • Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI)
  • May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256)
  • Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways
  • Inhibits retinoic acid-induced apoptosis (PubMed:21576111).

Compare Similar Items

Show Difference

Img

Bethyl Laboratories, Inc

50-155-9264

--


Antigen:
Senataxin

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
SETX

Gene Alias:
ALS4, amyotrophic lateral sclerosis 4, amyotrophic lateral sclerosis 4 protein, AOA2, bA479K20.2, KIAA0625, SCAR1, SEN1 homolog, Senataxin, spinocerebellar ataxia, recessive, non-Friedreich type 1

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
23064

Content And Storage:
4° C

Form:
Liquid

Applications:
Immunoprecipitation, Western Blot

Concentration:
1 mg/ml

Formulation:
phosphate, tris citrate with 0.09% sodium azide; pH 7-8

Gene Accession No.:
Q7Z333

Gene Symbols:
SETX

Immunogen:
Between 875 and 925

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG

Img

Bethyl Laboratories, Inc

50-155-9266

--


Antigen:
Senataxin

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
SETX

Gene Alias:
ALS4, amyotrophic lateral sclerosis 4, amyotrophic lateral sclerosis 4 protein, AOA2, bA479K20.2, KIAA0625, SCAR1, SEN1 homolog, Senataxin, spinocerebellar ataxia, recessive, non-Friedreich type 1

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
23064

Content And Storage:
4° C

Form:
Liquid

Applications:
Western Blot

Concentration:
__

Formulation:
TBS with 0.1% BSA and 0.09% sodium azide

Gene Accession No.:
Q7Z333

Gene Symbols:
SETX

Immunogen:
Between 875 and 925

Quantity:
20 μL

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG

Img

Bethyl Laboratories, Inc

50-155-9267

--


Antigen:
Senataxin

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
SETX

Gene Alias:
ALS4, amyotrophic lateral sclerosis 4, amyotrophic lateral sclerosis 4 protein, AOA2, bA479K20.2, KIAA0625, SCAR1, SEN1 homolog, Senataxin, spinocerebellar ataxia, recessive, non-Friedreich type 1

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
23064

Content And Storage:
4° C

Form:
Liquid

Applications:
Immunoprecipitation, Western Blot

Concentration:
1 mg/ml

Formulation:
phosphate, tris citrate with 0.09% sodium azide; pH 7-8

Gene Accession No.:
Q7Z333

Gene Symbols:
SETX

Immunogen:
Between 2627 and 2677

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG

Img

Bethyl Laboratories, Inc

50-155-9269

--


Antigen:
Senataxin

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
SETX

Gene Alias:
ALS4, amyotrophic lateral sclerosis 4, amyotrophic lateral sclerosis 4 protein, AOA2, bA479K20.2, KIAA0625, SCAR1, SEN1 homolog, Senataxin, spinocerebellar ataxia, recessive, non-Friedreich type 1

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
23064

Content And Storage:
4° C

Form:
Liquid

Applications:
Western Blot

Concentration:
__

Formulation:
TBS with 0.1% BSA and 0.09% sodium azide

Gene Accession No.:
Q7Z333

Gene Symbols:
SETX

Immunogen:
Between 2627 and 2677

Quantity:
20 μL

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG