eIF4G1/eIF4GI Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Description

• The recommended shelf life for this product is 1 year from date of receipt
• Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections
• The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F
• This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis
• The recognition of the mRNA cap and the ATP-dependent unwinding of 5′-terminal secondary structure is catalyzed by factors in this complex
• The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex
• A domain at its N-terminus can also interact with the poly-binding protein, which may mediate the circularization of mRNA during translation
• Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage.