WDR4 Polyclonal Antibody, Bethyl Laboratories

Description

• The recommended shelf life for this product is 1 year from date of receipt
• Required for 7-methylguanosine modification of tRNA
• This protein is a member of the WD repeat protein family
• WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD)
• which may facilitate formation of heterotrimeric or multiprotein complexes
• Members of this family are involved in a variety of cellular processes
• including cell cycle progression
• signal transduction
• apoptosis
• and gene regulation
• This protein is excluded as a candidate for a form of nonsyndromic deafness (DFNB10)
• but is still a candidate for other disorders mapped to 21q22.3 as well as for the development of Down syndrome phenotypes
• Alternative splicing of this gene generates at least 3 transcript variants
• two of which diverge at the 3′ UTR and thus encode the same protein products.