50-156-1239
VprBP Rabbit anti-Human, Polyclonal, Bethyl Laboratories
Manufacturer: Bethyl Laboratories, Inc
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-156-1239-Each-of-1 | In Stock | ₹ 41,863.65 |
50-156-1239 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,863.65
GST (18%): ₹ 7,535.457
Total Price: ₹ 49,399.107
Antigen
VprBP
Classification
Polyclonal
Conjugate
Unconjugated
Gene
DCAF1
Gene Alias
DCAF1, DDB1 and CUL4 associated factor 1, DDB1- and CUL4-associated factor 1, HIV-1 Vpr-binding protein, KIAA0800, MGC102804, serine/threonine-protein kinase VPRBP, Vpr (HIV-1) binding protein, Vpr-binding protein, VPRBP, vpr-interacting protein
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
9730
Content And Storage
4° C
Form
Liquid
Applications
Immunoprecipitation, Western Blot
Concentration
0.2 mg/ml
Formulation
TBS with 0.1% BSA and 0.09% sodium azide
Gene Accession No.
Q9Y4B6
Gene Symbols
DCAF1
Immunogen
Between 1457 and 1507
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- The recommended shelf life for this product is 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and histone modification
- Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2
- Involved in the turnover of methylated proteins: recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex (PubMed:23063525)
- The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: VPRBP is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination
- Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of proteins such as TERT, leading to TERT degradation and telomerase inhibition (PubMed:23362280)
- Also acts as an atypical serine/threonine-protein kinase that specifically mediates phosphorylation of ′Thr-120′ of histone H2A (H2AT120ph) in a nucleosomal context, thereby repressing transcription
- H2AT120ph is present in the regulatory region of many tumor suppresor genes, down-regulates their transcription and is present at high level in a number of tumors (PubMed:24140421)
- Involved in JNK-mediated apoptosis during cell competition process via its interaction with LLGL1 and LLGL2 (PubMed:20644714)
- In case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to arrest the cell cycle in G2 phase, and also to protect the viral protein from proteasomal degradation by another E3 ubiquitin ligase
- The HIV-1 Vpr protein hijacks the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex to promote ubiquitination and degradation of proteins such as TERT and ZIP/ZGPAT
- In case of infection by HIV-2 virus, it is recruited by HIV-2 Vpx in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to enhanced efficiency of macrophage infection and promotion of the replication of cognate primate lentiviruses in cells of monocyte/macrophage lineage.
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Show Difference
Antigen: VprBP
Classification: Polyclonal
Conjugate: Unconjugated
Gene: DCAF1
Gene Alias: DCAF1, DDB1 and CUL4 associated factor 1, DDB1- and CUL4-associated factor 1, HIV-1 Vpr-binding protein, KIAA0800, MGC102804, serine/threonine-protein kinase VPRBP, Vpr (HIV-1) binding protein, Vpr-binding protein, VPRBP, vpr-interacting protein
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 9730
Content And Storage: 4° C
Form: Liquid
Applications: Immunoprecipitation, Western Blot
Concentration: 0.2 mg/ml
Formulation: TBS with 0.1% BSA and 0.09% sodium azide
Gene Accession No.: Q9Y4B6
Gene Symbols: DCAF1
Immunogen: Between 1457 and 1507
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
VprBP
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
DCAF1
Gene Alias:
DCAF1, DDB1 and CUL4 associated factor 1, DDB1- and CUL4-associated factor 1, HIV-1 Vpr-binding protein, KIAA0800, MGC102804, serine/threonine-protein kinase VPRBP, Vpr (HIV-1) binding protein, Vpr-binding protein, VPRBP, vpr-interacting protein
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
9730
Content And Storage:
4° C
Form:
Liquid
Applications:
Immunoprecipitation, Western Blot
Concentration:
0.2 mg/ml
Formulation:
TBS with 0.1% BSA and 0.09% sodium azide
Gene Accession No.:
Q9Y4B6
Gene Symbols:
DCAF1
Immunogen:
Between 1457 and 1507
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: SOS1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: SOS1
Gene Alias: GF1; GGF1; GINGF; HGF; NS4; SOS-1; gingival fibromatosis; hereditary; 1; guanine nucleotide exchange factor; son of sevenless homolog 1
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 6654
Content And Storage: 4° C
Form: Liquid
Applications: Immunoprecipitation
Concentration: 1 mg/ml
Formulation: phosphate, tris citrate with 0.09% sodium azide; pH 7-8
Gene Accession No.: Q07889
Gene Symbols: SOS1
Immunogen: Between 1025 and 1075
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
SOS1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
SOS1
Gene Alias:
GF1; GGF1; GINGF; HGF; NS4; SOS-1; gingival fibromatosis; hereditary; 1; guanine nucleotide exchange factor; son of sevenless homolog 1
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
6654
Content And Storage:
4° C
Form:
Liquid
Applications:
Immunoprecipitation
Concentration:
1 mg/ml
Formulation:
phosphate, tris citrate with 0.09% sodium azide; pH 7-8
Gene Accession No.:
Q07889
Gene Symbols:
SOS1
Immunogen:
Between 1025 and 1075
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: SOS1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: SOS1
Gene Alias: GF1; GGF1; GINGF; HGF; NS4; SOS-1; gingival fibromatosis; hereditary; 1; guanine nucleotide exchange factor; son of sevenless homolog 1
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 6654
Content And Storage: 4° C
Form: Liquid
Applications: Immunoprecipitation
Concentration: 1 mg/ml
Formulation: phosphate, tris citrate with 0.09% sodium azide; pH 7-8
Gene Accession No.: Q07889
Gene Symbols: SOS1
Immunogen: Between 1025 and 1075
Quantity: 10 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
SOS1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
SOS1
Gene Alias:
GF1; GGF1; GINGF; HGF; NS4; SOS-1; gingival fibromatosis; hereditary; 1; guanine nucleotide exchange factor; son of sevenless homolog 1
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
6654
Content And Storage:
4° C
Form:
Liquid
Applications:
Immunoprecipitation
Concentration:
1 mg/ml
Formulation:
phosphate, tris citrate with 0.09% sodium azide; pH 7-8
Gene Accession No.:
Q07889
Gene Symbols:
SOS1
Immunogen:
Between 1025 and 1075
Quantity:
10 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: SOS1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: SOS1
Gene Alias: GF1; GGF1; GINGF; HGF; NS4; SOS-1; gingival fibromatosis; hereditary; 1; guanine nucleotide exchange factor; son of sevenless homolog 1
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 6654
Content And Storage: 4° C
Form: Liquid
Applications: Immunoprecipitation, Western Blot
Concentration: 0.2 mg/ml
Formulation: TBS with 0.1% BSA and 0.09% sodium azide
Gene Accession No.: Q07889
Gene Symbols: SOS1
Immunogen: Between 1283 and 1333
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
SOS1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
SOS1
Gene Alias:
GF1; GGF1; GINGF; HGF; NS4; SOS-1; gingival fibromatosis; hereditary; 1; guanine nucleotide exchange factor; son of sevenless homolog 1
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
6654
Content And Storage:
4° C
Form:
Liquid
Applications:
Immunoprecipitation, Western Blot
Concentration:
0.2 mg/ml
Formulation:
TBS with 0.1% BSA and 0.09% sodium azide
Gene Accession No.:
Q07889
Gene Symbols:
SOS1
Immunogen:
Between 1283 and 1333
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG