LAP1B Polyclonal Antibody, Bethyl Laboratories

Description

• The recommended shelf life for this product is 1 year from date of receipt
• In eukaryotic cells, the nuclear envelope consists of inner and outer membranes which define the border between the nucleus and cytoplasm
• The inner and outer nuclear membranes are joined by large, supramolecular assemblies called nuclear pore complexes through which various molecules pass into and out of the nucleus
• The inner membrane is lined by a filamentous meshwork called the nuclear lamina made up of proteins called lamins
• The attachment of the lamins to the inner nuclear membrane appears to occur through their association with 4 related integral membrane proteins called Lamin Associated Polypeptides (LAPs)
• LAP 1A, 1B & 1C share a high degree of sequence homology while LAP 2 is distinct from the others
• LAP 1A & B bind lamins A, C and B1, while LAP 2 binds lamin B1 only
• In addition to lamin binding, LAP 2 has been shown to bind to chromosomes
• Phosphorylation of LAP 2 during mitosis inhibits binding to both lamins and chromosomes suggesting that LAP 2 plays an important role in nuclear envelope re-assembly.